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515 related items for PubMed ID: 10587643

  • 1. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec; 1(8):479-85. PubMed ID: 10587643
    [Abstract] [Full Text] [Related]

  • 2. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 3. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
    Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G.
    Nat Cell Biol; 2000 Dec 15; 2(12):863-70. PubMed ID: 11146649
    [Abstract] [Full Text] [Related]

  • 4. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein.
    Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H.
    Brain Res Mol Brain Res; 2005 Jun 13; 137(1-2):70-6. PubMed ID: 15950763
    [Abstract] [Full Text] [Related]

  • 5. Induction of neuronal death by ER stress in Alzheimer's disease.
    Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M.
    J Chem Neuroanat; 2004 Sep 13; 28(1-2):67-78. PubMed ID: 15363492
    [Abstract] [Full Text] [Related]

  • 6. The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis.
    Hoozemans JJ, Stieler J, van Haastert ES, Veerhuis R, Rozemuller AJ, Baas F, Eikelenboom P, Arendt T, Scheper W.
    Exp Gerontol; 2006 Apr 13; 41(4):380-6. PubMed ID: 16564150
    [Abstract] [Full Text] [Related]

  • 7. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis.
    Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA.
    Nature; 1998 Oct 15; 395(6703):698-702. PubMed ID: 9790190
    [Abstract] [Full Text] [Related]

  • 8. Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin.
    Piccini A, Fassio A, Pasqualetto E, Vitali A, Borghi R, Palmieri D, Nacmias B, Sorbi S, Sitia R, Tabaton M.
    Neurobiol Dis; 2004 Mar 15; 15(2):380-6. PubMed ID: 15006708
    [Abstract] [Full Text] [Related]

  • 9. A molecular chaperone inducer protects neurons from ER stress.
    Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K, Takeda M.
    Cell Death Differ; 2008 Feb 15; 15(2):364-75. PubMed ID: 18049481
    [Abstract] [Full Text] [Related]

  • 10. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug 15; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 11. Down-regulation of the endoplasmic reticulum chaperone GRP78/BiP by vomitoxin (Deoxynivalenol).
    Yang GH, Li S, Pestka JJ.
    Toxicol Appl Pharmacol; 2000 Feb 01; 162(3):207-17. PubMed ID: 10652249
    [Abstract] [Full Text] [Related]

  • 12. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 01; 8(2):331-42. PubMed ID: 11300728
    [Abstract] [Full Text] [Related]

  • 13. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
    Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ.
    Neurobiol Dis; 1997 Apr 01; 3(4):325-37. PubMed ID: 9173929
    [Abstract] [Full Text] [Related]

  • 14. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 01; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 15. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
    Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR.
    Neurobiol Aging; 2004 Aug 01; 25(7):885-92. PubMed ID: 15212842
    [Abstract] [Full Text] [Related]

  • 16. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES, Martinez M, Brunkan AL, Goate A.
    J Neurochem; 2005 Jan 01; 92(2):294-301. PubMed ID: 15663477
    [Abstract] [Full Text] [Related]

  • 17. Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.
    Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S.
    J Neurosci Res; 2003 Oct 15; 74(2):184-91. PubMed ID: 14515347
    [Abstract] [Full Text] [Related]

  • 18. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L, Gan L, Yu GQ, Essrich C, Mucke L.
    J Neurochem; 2004 Dec 15; 91(6):1260-74. PubMed ID: 15584903
    [Abstract] [Full Text] [Related]

  • 19. Amyloid precursor protein promotes endoplasmic reticulum stress-induced cell death via C/EBP homologous protein-mediated pathway.
    Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H.
    J Neurochem; 2009 Jun 15; 109(5):1324-37. PubMed ID: 19476545
    [Abstract] [Full Text] [Related]

  • 20. Presenilin-1 protein expression in familial and sporadic Alzheimer's disease.
    Levey AI, Heilman CJ, Lah JJ, Nash NR, Rees HD, Wakai M, Mirra SS, Rye DB, Nochlin D, Bird TD, Mufson EJ.
    Ann Neurol; 1997 Jun 15; 41(6):742-53. PubMed ID: 9189035
    [Abstract] [Full Text] [Related]

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