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Journal Abstract Search

147 related items for PubMed ID: 10606510

  • 1.
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  • 2. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
    Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA.
    Biochemistry; 2001 Nov 13; 40(45):13538-47. PubMed ID: 11695901
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  • 3. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
    Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA.
    Biochemistry; 2002 Dec 03; 41(48):14206-15. PubMed ID: 12450384
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  • 6. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.
    Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA.
    Biochemistry; 2003 May 27; 42(20):6043-56. PubMed ID: 12755606
    [Abstract] [Full Text] [Related]

  • 7. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 27; 5(9):1839-46. PubMed ID: 9354239
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  • 8. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase.
    Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 27; 5(9):1817-30. PubMed ID: 9354237
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  • 9. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 27; 10(8):2739-49. PubMed ID: 12057663
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  • 10. Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
    Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM.
    Biochemistry; 2000 Aug 01; 39(30):8791-802. PubMed ID: 10913290
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  • 12. Multisubstrate analogue based on 5,8,10-trideazafolate.
    Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 01; 5(9):1853-7. PubMed ID: 9354241
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  • 13. Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations.
    Morikis D, Elcock AH, Jennings PA, McCammon JA.
    Protein Sci; 2001 Nov 01; 10(11):2379-92. PubMed ID: 11604543
    [Abstract] [Full Text] [Related]

  • 14. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
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  • 15. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
    Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA.
    Biochemistry; 2003 Sep 23; 42(37):10904-14. PubMed ID: 12974624
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  • 16. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ.
    Bioorg Med Chem Lett; 2000 Jul 03; 10(13):1471-5. PubMed ID: 10888335
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  • 17. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase.
    Boger DL, Haynes NE, Warren MS, Gooljarsingh LT, Ramcharan J, Kitos PA, Benkovic SJ.
    Bioorg Med Chem; 1997 Sep 03; 5(9):1831-8. PubMed ID: 9354238
    [No Abstract] [Full Text] [Related]

  • 18. The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.
    Dahms TE, Sainz G, Giroux EL, Caperelli CA, Smith JL.
    Biochemistry; 2005 Jul 26; 44(29):9841-50. PubMed ID: 16026156
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  • 20. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
    Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4511-21. PubMed ID: 13129587
    [Abstract] [Full Text] [Related]

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