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156 related items for PubMed ID: 10611065

  • 1. Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
    D'Cruz OJ, Venkatachalam TK, Uckun FM.
    Biol Reprod; 2000 Jan; 62(1):37-44. PubMed ID: 10611065
    [Abstract] [Full Text] [Related]

  • 2. WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity.
    D'Cruz OJ, Zhu Z, Yiv SH, Chen CL, Waurzyniak B, Uckun FM.
    Contraception; 1999 May; 59(5):319-31. PubMed ID: 10494486
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities.
    D'Cruz OJ, Shih MJ, Yiv SH, Chen CL, Uckun FM.
    Mol Hum Reprod; 1999 May; 5(5):421-32. PubMed ID: 10338365
    [Abstract] [Full Text] [Related]

  • 4. Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus.
    D'Cruz OJ, Venkatachalam TK, Zhu Z, Shih MJ, Uckun FM.
    Biol Reprod; 1998 Sep; 59(3):503-15. PubMed ID: 9716547
    [Abstract] [Full Text] [Related]

  • 5. Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine.
    Venkatachalam TK, D'Cruz OJ, Uckun FM.
    Antivir Chem Chemother; 2000 Jan; 11(1):31-9. PubMed ID: 10693652
    [Abstract] [Full Text] [Related]

  • 6. Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm.
    D'Cruz OJ, Venkatachalam TK, Uckun FM.
    Biol Reprod; 2001 Jan; 64(1):51-9. PubMed ID: 11133658
    [Abstract] [Full Text] [Related]

  • 7. Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in rabbits.
    D'Cruz OJ, Uckun FM.
    Arzneimittelforschung; 2003 Jan; 53(7):515-21. PubMed ID: 12918218
    [Abstract] [Full Text] [Related]

  • 8. Novel thiourea compounds as dual-function microbicides.
    D'Cruz OJ, Venkatachalam TK, Uckun FM.
    Biol Reprod; 2000 Jul; 63(1):196-205. PubMed ID: 10859260
    [Abstract] [Full Text] [Related]

  • 9. Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07).
    D'Cruz OJ, Uckun FM.
    J Appl Toxicol; 2001 Jul; 21(4):317-22. PubMed ID: 11481666
    [Abstract] [Full Text] [Related]

  • 10. Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.
    D'Cruz OJ, Waurzyniak B, Yiv SH, Uckun FM.
    J Appl Toxicol; 2000 Jul; 20(4):319-25. PubMed ID: 10942907
    [Abstract] [Full Text] [Related]

  • 11. Structural requirements for potent anti-human immunodeficiency virus (HIV) and sperm-immobilizing activities of cyclohexenyl thiourea and urea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    D'Cruz OJ, Venkatachalam TK, Mao C, Qazi S, Uckun FM.
    Biol Reprod; 2002 Dec; 67(6):1959-74. PubMed ID: 12444075
    [Abstract] [Full Text] [Related]

  • 12. Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
    D'Cruz OJ, Uckun FM.
    J Antimicrob Chemother; 2002 Dec; 50(6):793-803. PubMed ID: 12460996
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice.
    D'Cruz OJ, Waurzyniak B, Yiv SH, Uckun FM.
    Contraception; 2000 Jan; 61(1):69-76. PubMed ID: 10745072
    [Abstract] [Full Text] [Related]

  • 15. Novel derivatives of phenethyl-5-bromopyridylthiourea and dihydroalkoxybenzyloxopyrimidine are dual-function spermicides with potent anti-human immunodeficiency virus activity.
    D'Cruz OJ, Uckun FM.
    Biol Reprod; 1999 Jun; 60(6):1419-28. PubMed ID: 10330101
    [Abstract] [Full Text] [Related]

  • 16. Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07).
    Uckun FM, Tai HL, D'Cruz OJ.
    Arzneimittelforschung; 2005 Jun; 55(1):50-65. PubMed ID: 15727164
    [Abstract] [Full Text] [Related]

  • 17. Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent.
    D'Cruz OJ, Erbeck D, Waurzyniak B, Uckun FM.
    Toxicology; 2002 Sep 30; 179(1-2):61-77. PubMed ID: 12204543
    [Abstract] [Full Text] [Related]

  • 18. Potent dual anti-HIV and spermicidal activities of novel oxovanadium(V) complexes with thiourea non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    D'Cruz OJ, Dong Y, Uckun FM.
    Biochem Biophys Res Commun; 2003 Mar 07; 302(2):253-64. PubMed ID: 12604339
    [Abstract] [Full Text] [Related]

  • 19. Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice.
    D'Cruz OJ, Uckun FM.
    Toxicol Sci; 2001 Apr 07; 60(2):373-8. PubMed ID: 11248150
    [Abstract] [Full Text] [Related]

  • 20. Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents.
    Jan ST, Shih MJ, Venkatachalam TK, D'Cruz OJ, Chen CL, Uckun FM.
    Antivir Chem Chemother; 1999 Jan 07; 10(1):39-46. PubMed ID: 10079878
    [Abstract] [Full Text] [Related]

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