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241 related items for PubMed ID: 10623831

  • 1. The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction.
    Schmitz J, Dahmen H, Grimm C, Gendo C, Müller-Newen G, Heinrich PC, Schaper F.
    J Immunol; 2000 Jan 15; 164(2):848-54. PubMed ID: 10623831
    [Abstract] [Full Text] [Related]

  • 2. TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex.
    Bode JG, Schweigart J, Kehrmann J, Ehlting C, Schaper F, Heinrich PC, Häussinger D.
    J Immunol; 2003 Jul 01; 171(1):257-66. PubMed ID: 12817006
    [Abstract] [Full Text] [Related]

  • 3. Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation.
    Anhuf D, Weissenbach M, Schmitz J, Sobota R, Hermanns HM, Radtke S, Linnemann S, Behrmann I, Heinrich PC, Schaper F.
    J Immunol; 2000 Sep 01; 165(5):2535-43. PubMed ID: 10946280
    [Abstract] [Full Text] [Related]

  • 4. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
    Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC.
    Biochem J; 1998 Nov 01; 335 ( Pt 3)(Pt 3):557-65. PubMed ID: 9794795
    [Abstract] [Full Text] [Related]

  • 5. Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130.
    Hermanns HM, Radtke S, Haan C, Schmitz-Van de Leur H, Tavernier J, Heinrich PC, Behrmann I.
    J Immunol; 1999 Dec 15; 163(12):6651-8. PubMed ID: 10586060
    [Abstract] [Full Text] [Related]

  • 6. Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.
    Kim H, Baumann H.
    Mol Cell Biol; 1999 Aug 15; 19(8):5326-38. PubMed ID: 10409724
    [Abstract] [Full Text] [Related]

  • 7. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.
    Yamanaka Y, Nakajima K, Fukada T, Hibi M, Hirano T.
    EMBO J; 1996 Apr 01; 15(7):1557-65. PubMed ID: 8612579
    [Abstract] [Full Text] [Related]

  • 8. Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach.
    French JD, Tschumper RC, Jelinek DF.
    Leukemia; 2002 Jun 01; 16(6):1189-96. PubMed ID: 12040452
    [Abstract] [Full Text] [Related]

  • 9. Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation.
    Pflanz S, Kurth I, Grötzinger J, Heinrich PC, Müller-Newen G.
    J Immunol; 2000 Dec 15; 165(12):7042-9. PubMed ID: 11120832
    [Abstract] [Full Text] [Related]

  • 10. Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.
    Novotny-Diermayr V, Lin B, Gu L, Cao X.
    J Biol Chem; 2005 Apr 01; 280(13):12747-57. PubMed ID: 15677447
    [Abstract] [Full Text] [Related]

  • 11. Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation.
    Gerhartz C, Heesel B, Sasse J, Hemmann U, Landgraf C, Schneider-Mergener J, Horn F, Heinrich PC, Graeve L.
    J Biol Chem; 1996 May 31; 271(22):12991-8. PubMed ID: 8662591
    [Abstract] [Full Text] [Related]

  • 12. Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130.
    Kurth I, Horsten U, Pflanz S, Timmermann A, Küster A, Dahmen H, Tacken I, Heinrich PC, Müller-Newen G.
    J Immunol; 2000 Jan 01; 164(1):273-82. PubMed ID: 10605021
    [Abstract] [Full Text] [Related]

  • 13. Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.
    Dahmen H, Horsten U, Küster A, Jacques Y, Minvielle S, Kerr IM, Ciliberto G, Paonessa G, Heinrich PC, Müller-Newen G.
    Biochem J; 1998 May 01; 331 ( Pt 3)(Pt 3):695-702. PubMed ID: 9560294
    [Abstract] [Full Text] [Related]

  • 14. Protein tyrosine phosphatase 2 (SHP-2) moderates signaling by gp130 but is not required for the induction of acute-phase plasma protein genes in hepatic cells.
    Kim H, Hawley TS, Hawley RG, Baumann H.
    Mol Cell Biol; 1998 Mar 01; 18(3):1525-33. PubMed ID: 9488469
    [Abstract] [Full Text] [Related]

  • 15. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activation.
    Hemmann U, Gerhartz C, Heesel B, Sasse J, Kurapkat G, Grötzinger J, Wollmer A, Zhong Z, Darnell JE, Graeve L, Heinrich PC, Horn F.
    J Biol Chem; 1996 May 31; 271(22):12999-3007. PubMed ID: 8662795
    [Abstract] [Full Text] [Related]

  • 16. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
    Heinrich PC, Behrmann I, Müller-Newen G, Schaper F, Graeve L.
    Biochem J; 1998 Sep 01; 334 ( Pt 2)(Pt 2):297-314. PubMed ID: 9716487
    [Abstract] [Full Text] [Related]

  • 17. Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
    Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G.
    J Immunol; 1997 May 01; 158(9):4097-103. PubMed ID: 9126968
    [Abstract] [Full Text] [Related]

  • 18. Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1.
    Kortylewski M, Heinrich PC, Mackiewicz A, Schniertshauer U, Klingmüller U, Nakajima K, Hirano T, Horn F, Behrmann I.
    Oncogene; 1999 Jun 24; 18(25):3742-53. PubMed ID: 10391682
    [Abstract] [Full Text] [Related]

  • 19. Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex.
    Horsten U, Müller-Newen G, Gerhartz C, Wollmer A, Wijdenes J, Heinrich PC, Grötzinger J.
    J Biol Chem; 1997 Sep 19; 272(38):23748-57. PubMed ID: 9295319
    [Abstract] [Full Text] [Related]

  • 20. The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.
    Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Müller-Newen G, Heinrich PC, Schaper F.
    Biochem J; 2004 Mar 01; 378(Pt 2):449-60. PubMed ID: 14611646
    [Abstract] [Full Text] [Related]

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