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Journal Abstract Search

1755 related items for PubMed ID: 10653281

  • 1. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
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  • 2. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W.
    Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
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  • 4. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D.
    Proc Natl Acad Sci U S A; 2005 Jun 21; 102(25):8972-7. PubMed ID: 15951428
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  • 6. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
    Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C.
    EMBO J; 2002 Oct 15; 21(20):5408-16. PubMed ID: 12374741
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  • 7. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D, Kienlen-Campard P, Octave JN.
    J Neurochem; 2002 Oct 15; 83(2):390-9. PubMed ID: 12423249
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  • 8. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
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  • 9. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
    Kim M, Bezprozvanny I.
    Int J Mol Sci; 2023 Jan 20; 24(3):. PubMed ID: 36768421
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  • 10. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
    Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE.
    J Biol Chem; 2000 Nov 24; 275(47):36794-802. PubMed ID: 10962005
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  • 13. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
    Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H.
    Proc Natl Acad Sci U S A; 2002 Jun 11; 99(12):8025-30. PubMed ID: 12048239
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  • 14. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
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  • 15. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis.
    Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C.
    Biochemistry; 1999 Nov 02; 38(44):14600-5. PubMed ID: 10545183
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  • 17. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
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  • 18. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
    Islam S, Sun Y, Gao Y, Nakamura T, Noorani AA, Li T, Wong PC, Kimura N, Matsubara E, Kasuga K, Ikeuchi T, Tomita T, Zou K, Michikawa M.
    J Neurosci; 2022 Feb 23; 42(8):1574-1586. PubMed ID: 34987110
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  • 20. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 23; 96(3):732-42. PubMed ID: 16405513
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