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Journal Abstract Search

325 related items for PubMed ID: 10681367

  • 1. In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.
    Houston JB, Kenworthy KE.
    Drug Metab Dispos; 2000 Mar; 28(3):246-54. PubMed ID: 10681367
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  • 3. Sigmoidal kinetics of CYP3A substrates: an approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat.
    Witherow LE, Houston JB.
    J Pharmacol Exp Ther; 1999 Jul; 290(1):58-65. PubMed ID: 10381760
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  • 4. Atypical cytochrome p450 kinetics: implications for drug discovery.
    Tracy TS.
    Drugs R D; 2006 Jul; 7(6):349-63. PubMed ID: 17073518
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  • 8. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.
    Naritomi Y, Terashita S, Kimura S, Suzuki A, Kagayama A, Sugiyama Y.
    Drug Metab Dispos; 2001 Oct; 29(10):1316-24. PubMed ID: 11560875
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  • 9. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM, Houston JB.
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
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  • 11. Prediction of human pharmacokinetics--gut-wall metabolism.
    Fagerholm U.
    J Pharm Pharmacol; 2007 Oct; 59(10):1335-43. PubMed ID: 17910807
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  • 14. Characterization of the cytochrome P450 enzymes and enzyme kinetic parameters for metabolism of BVT.2938 using different in vitro systems.
    Baranczewski P, Edlund PO, Postlind H.
    J Pharm Biomed Anal; 2006 Mar 18; 40(5):1121-30. PubMed ID: 16307862
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  • 16. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
    Riley RJ, McGinnity DF, Austin RP.
    Drug Metab Dispos; 2005 Sep 18; 33(9):1304-11. PubMed ID: 15932954
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  • 17. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 18; 27(8):371-86. PubMed ID: 16944451
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  • 19. Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s.
    McGinnity DF, Parker AJ, Soars M, Riley RJ.
    Drug Metab Dispos; 2000 Nov 18; 28(11):1327-34. PubMed ID: 11038161
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  • 20. Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
    Zhou S, Kestell P, Tingle MD, Paxton JW.
    Cancer Chemother Pharmacol; 2002 Feb 18; 49(2):126-32. PubMed ID: 11862426
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