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314 related items for PubMed ID: 10681541

  • 1. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.
    Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H.
    J Biol Chem; 2000 Feb 25; 275(8):5600-5. PubMed ID: 10681541
    [Abstract] [Full Text] [Related]

  • 2. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.
    Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN.
    Cancer Res; 2000 Apr 15; 60(8):2108-12. PubMed ID: 10786669
    [Abstract] [Full Text] [Related]

  • 3. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
    Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y.
    Cancer Res; 2002 Oct 15; 62(20):5743-8. PubMed ID: 12384533
    [Abstract] [Full Text] [Related]

  • 4. Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
    Hutchins JR, Dikovskaya D, Clarke PR.
    Mol Biol Cell; 2003 Oct 15; 14(10):4003-14. PubMed ID: 14517314
    [Abstract] [Full Text] [Related]

  • 5. UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
    Yu L, Orlandi L, Wang P, Orr MS, Senderowicz AM, Sausville EA, Silvestrini R, Watanabe N, Piwnica-Worms H, O'Connor PM.
    J Biol Chem; 1998 Dec 11; 273(50):33455-64. PubMed ID: 9837924
    [Abstract] [Full Text] [Related]

  • 6. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
    Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.
    J Biol Chem; 2000 Apr 07; 275(14):10342-8. PubMed ID: 10744722
    [Abstract] [Full Text] [Related]

  • 7. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1.
    Furnari B, Blasina A, Boddy MN, McGowan CH, Russell P.
    Mol Biol Cell; 1999 Apr 07; 10(4):833-45. PubMed ID: 10198041
    [Abstract] [Full Text] [Related]

  • 8. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
    Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A.
    J Biol Chem; 2002 Jul 19; 277(29):26553-64. PubMed ID: 11953432
    [Abstract] [Full Text] [Related]

  • 9. Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
    Shao RG, Cao CX, Pommier Y.
    Acta Pharmacol Sin; 2004 Jun 19; 25(6):756-62. PubMed ID: 15169628
    [Abstract] [Full Text] [Related]

  • 10. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells.
    Hirose Y, Berger MS, Pieper RO.
    Cancer Res; 2001 Aug 01; 61(15):5843-9. PubMed ID: 11479224
    [Abstract] [Full Text] [Related]

  • 11. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.
    Blasina A, de Weyer IV, Laus MC, Luyten WH, Parker AE, McGowan CH.
    Curr Biol; 1999 Jan 14; 9(1):1-10. PubMed ID: 9889122
    [Abstract] [Full Text] [Related]

  • 12. p53-dependent Chk1 phosphorylation is required for maintenance of prolonged G2 Arrest.
    Wang XQ, Stanbridge EJ, Lao X, Cai Q, Fan ST, Redpath JL.
    Radiat Res; 2007 Dec 14; 168(6):706-15. PubMed ID: 18088187
    [Abstract] [Full Text] [Related]

  • 13. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.
    J Natl Cancer Inst; 1996 Jul 17; 88(14):956-65. PubMed ID: 8667426
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of cyclin-dependent kinase 2 by the Chk1-Cdc25A pathway during the S-phase checkpoint activated by fludarabine: dysregulation by 7-hydroxystaurosporine.
    Sampath D, Shi Z, Plunkett W.
    Mol Pharmacol; 2002 Sep 17; 62(3):680-8. PubMed ID: 12181445
    [Abstract] [Full Text] [Related]

  • 15. Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.
    Tsvetkov L, Stern DF.
    Cell Cycle; 2005 Jan 17; 4(1):166-71. PubMed ID: 15611664
    [Abstract] [Full Text] [Related]

  • 16. Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.
    Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R.
    Carcinogenesis; 2005 Nov 17; 26(11):1978-87. PubMed ID: 15975956
    [Abstract] [Full Text] [Related]

  • 17. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1.
    Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T.
    Nature; 1998 Oct 01; 395(6701):507-10. PubMed ID: 9774107
    [Abstract] [Full Text] [Related]

  • 18. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A, Kohn EA, Brown MK, Rathman J, Livingstone M, Blank DH, Gribble GW.
    Mol Cancer Ther; 2002 Oct 01; 1(12):1067-78. PubMed ID: 12481430
    [Abstract] [Full Text] [Related]

  • 19. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
    Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB.
    Cancer Cell; 2007 Feb 01; 11(2):175-89. PubMed ID: 17292828
    [Abstract] [Full Text] [Related]

  • 20. Replication checkpoint enforced by kinases Cds1 and Chk1.
    Boddy MN, Furnari B, Mondesert O, Russell P.
    Science; 1998 May 08; 280(5365):909-12. PubMed ID: 9572736
    [Abstract] [Full Text] [Related]

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