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Journal Abstract Search

484 related items for PubMed ID: 1068451

  • 1. Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.
    Thakker DR, Yagi H, Lu AY, Levin W, Conney AH.
    Proc Natl Acad Sci U S A; 1976 Oct; 73(10):3381-5. PubMed ID: 1068451
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes.
    Wood AW, Levin W, Lu AY, Yagi H, Hernandez O, Jerina DM, Conney AH.
    J Biol Chem; 1976 Aug 25; 251(16):4882-90. PubMed ID: 821945
    [Abstract] [Full Text] [Related]

  • 3. Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.
    Kapitulnik J, Wislocki PG, Levin W, Yagi H, Jerina DM, Conney AH.
    Cancer Res; 1978 Feb 25; 38(2):354-8. PubMed ID: 620406
    [Abstract] [Full Text] [Related]

  • 4. Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.
    Yang SK, McCourt DW, Roller PP, Gelboin HV.
    Proc Natl Acad Sci U S A; 1976 Aug 25; 73(8):2594-8. PubMed ID: 1066669
    [Abstract] [Full Text] [Related]

  • 5. Regio- and stereoselectivity of various forms of purified cytochrome P-450 in the metabolism of benzo[a]pyrene and (-) trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as shown by product formation and binding to DNA.
    Deutsch J, Leutz JC, Yang SK, Gelboin HV, Chiang YL, Vatsis KP, Coon MJ.
    Proc Natl Acad Sci U S A; 1978 Jul 25; 75(7):3123-7. PubMed ID: 277915
    [Abstract] [Full Text] [Related]

  • 6. Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.
    Wood AW, Wislocki PG, Chang RL, Levin W, Lu AY, Yagi J, Hernandez O, Herina DM, Conney AH.
    Cancer Res; 1976 Sep 25; 36(9 pt.1):3358-66. PubMed ID: 788899
    [Abstract] [Full Text] [Related]

  • 7. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.
    Buening MK, Wislocki PG, Levin W, Yagi H, Thakker DR, Akagi H, Koreeda M, Jerina DM, Conney AH.
    Proc Natl Acad Sci U S A; 1978 Nov 25; 75(11):5358-61. PubMed ID: 281685
    [Abstract] [Full Text] [Related]

  • 8. Regioselectivity and stereoselectivity in the metabolism of trans-1,2-dihydroxy-1,2-dihydrobenz[a]anthracene by rat liver microsomes.
    Vyas KP, van Bladeren PJ, Thakker DR, Yagi H, Sayer JM, Levin W, Jerina DM.
    Mol Pharmacol; 1983 Jul 25; 24(1):115-23. PubMed ID: 6865920
    [Abstract] [Full Text] [Related]

  • 9. Effects of a 6-fluoro substituent on the metabolism of benzo(a)pyrene 7,8-dihydrodiol to bay-region diol epoxides by rat liver enzymes.
    Thakker DR, Yagi H, Sayer JM, Kapur U, Levin W, Chang RL, Wood AW, Conney AH, Jerina DM.
    J Biol Chem; 1984 Sep 25; 259(18):11249-56. PubMed ID: 6432795
    [Abstract] [Full Text] [Related]

  • 10. Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.
    Thakker DR, Levin W, Buening M, Yagi H, Lehr RE, Wood AW, Conney AH, Jerina DM.
    Cancer Res; 1981 Apr 25; 41(4):1389-96. PubMed ID: 7194138
    [Abstract] [Full Text] [Related]

  • 11. Inhibitory effect of 3-hydroxybenzo(a)pyrene on the mutagenicity and tumorigenicity of (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene.
    Huang MT, Wood AW, Chang RL, Yagi H, Sayer JM, Jerina DM, Conney AH.
    Cancer Res; 1986 Feb 25; 46(2):558-66. PubMed ID: 3079665
    [Abstract] [Full Text] [Related]

  • 12. Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.
    Huberman E, Sachs L, Yang SK, Gelboin V.
    Proc Natl Acad Sci U S A; 1976 Feb 25; 73(2):607-11. PubMed ID: 1061161
    [Abstract] [Full Text] [Related]

  • 13. Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats.
    Adams JD, Yagi H, Levin W, Jerina DM.
    Chem Biol Interact; 1995 Mar 30; 95(1-2):57-77. PubMed ID: 7697754
    [Abstract] [Full Text] [Related]

  • 14. Benzo[a]pyrene diol epoxides: mechanism of enzymatic formation and optically active intermediates.
    Yang SK, McCourt DW, Leutz JC, Gelboin HV.
    Science; 1977 Jun 10; 196(4295):1199-201. PubMed ID: 870975
    [Abstract] [Full Text] [Related]

  • 15. Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, beta-naphthoflavone and phenobarbital treated rats.
    Gozukara EM, Guengerich FP, Miller H, Gelboin HV.
    Carcinogenesis; 1982 Jun 10; 3(2):129-33. PubMed ID: 6279326
    [Abstract] [Full Text] [Related]

  • 16. Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.
    Hamman JP, Seliger HH, Posner GH.
    Proc Natl Acad Sci U S A; 1981 Feb 10; 78(2):940-2. PubMed ID: 6785756
    [Abstract] [Full Text] [Related]

  • 17. Metabolic activation of benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide to protein-binding products and the inhibitory effect of glutathione and cysteine.
    Jernström B, Dock L, Martinez M.
    Carcinogenesis; 1984 Feb 10; 5(2):199-204. PubMed ID: 6421502
    [Abstract] [Full Text] [Related]

  • 18. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.
    Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP.
    Cancer Res; 1989 Nov 15; 49(22):6304-12. PubMed ID: 2509067
    [Abstract] [Full Text] [Related]

  • 19. Novel stereoselectivity of rat liver cytochrome(s) P450 toward enantiomers of the trans-1,2-dihydrodiol of triphenylene.
    Thakker DR, Boehlert C, Levin W, Ryan DE, Thomas PE, Yagi H, Jerina DM.
    Arch Biochem Biophys; 1991 Jul 15; 288(1):54-63. PubMed ID: 1898024
    [Abstract] [Full Text] [Related]

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