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500 related items for PubMed ID: 10684867

  • 1. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
    Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.
    J Neurosci; 2000 Mar 01; 20(5):1657-65. PubMed ID: 10684867
    [Abstract] [Full Text] [Related]

  • 2. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
    Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.
    J Biol Chem; 1998 Dec 04; 273(49):32730-8. PubMed ID: 9830016
    [Abstract] [Full Text] [Related]

  • 3. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
    Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S.
    Proc Natl Acad Sci U S A; 2003 Apr 01; 100(7):4162-7. PubMed ID: 12634421
    [Abstract] [Full Text] [Related]

  • 4. Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.
    Sahoo BR, Panda PK, Liang W, Tang WJ, Ahuja R, Ramamoorthy A.
    J Mol Biol; 2021 Jun 25; 433(13):166993. PubMed ID: 33865867
    [Abstract] [Full Text] [Related]

  • 5. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
    Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ.
    Am J Pathol; 2004 Apr 25; 164(4):1425-34. PubMed ID: 15039230
    [Abstract] [Full Text] [Related]

  • 6. CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain.
    Vingtdeux V, Chandakkar P, Zhao H, Blanc L, Ruiz S, Marambaud P.
    J Cell Sci; 2015 Jul 01; 128(13):2330-8. PubMed ID: 25999473
    [Abstract] [Full Text] [Related]

  • 7. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes.
    Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K.
    Neuroscience; 2018 Aug 10; 385():227-236. PubMed ID: 29932983
    [Abstract] [Full Text] [Related]

  • 8. Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.
    Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.
    Biochem Cell Biol; 2016 Dec 10; 94(6):534-542. PubMed ID: 27813426
    [Abstract] [Full Text] [Related]

  • 9. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
    Tamboli IY, Barth E, Christian L, Siepmann M, Kumar S, Singh S, Tolksdorf K, Heneka MT, Lütjohann D, Wunderlich P, Walter J.
    J Biol Chem; 2010 Nov 26; 285(48):37405-14. PubMed ID: 20876579
    [Abstract] [Full Text] [Related]

  • 10. BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).
    Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J.
    J Biol Chem; 2011 Oct 28; 286(43):37446-57. PubMed ID: 21873424
    [Abstract] [Full Text] [Related]

  • 11. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease.
    Del Campo M, Stargardt A, Veerhuis R, Reits E, Teunissen CE.
    Neurosci Lett; 2015 Mar 04; 589():47-51. PubMed ID: 25597881
    [Abstract] [Full Text] [Related]

  • 12. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.
    Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM.
    J Neurosci; 2004 Dec 08; 24(49):11120-6. PubMed ID: 15590928
    [Abstract] [Full Text] [Related]

  • 13. Cell Signaling Mechanisms by which Geniposide Regulates Insulin- Degrading Enzyme Expression in Primary Cortical Neurons.
    Zhang Y, Xia Z, Liu J, Yin F.
    CNS Neurol Disord Drug Targets; 2015 Dec 08; 14(3):370-7. PubMed ID: 25544681
    [Abstract] [Full Text] [Related]

  • 14. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
    Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.
    Biochemistry; 2005 May 03; 44(17):6513-25. PubMed ID: 15850385
    [Abstract] [Full Text] [Related]

  • 15. Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
    Tundo G, Ciaccio C, Sbardella D, Boraso M, Viviani B, Coletta M, Marini S.
    PLoS One; 2012 May 03; 7(4):e34376. PubMed ID: 22509294
    [Abstract] [Full Text] [Related]

  • 16. Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides.
    Kurochkin IV, Guarnera E, Wong JH, Eisenhaber F, Berezovsky IN.
    Biochemistry; 2017 Jan 10; 56(1):228-239. PubMed ID: 27982586
    [Abstract] [Full Text] [Related]

  • 17. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease.
    Kim DH, Lee D, Lim H, Choi SJ, Oh W, Yang YS, Chang JH, Jeon HB.
    Biochem Biophys Res Commun; 2018 Oct 12; 504(4):933-940. PubMed ID: 30224067
    [Abstract] [Full Text] [Related]

  • 18. Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.
    Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H.
    J Neurosci; 2001 Apr 15; 21(8):2561-70. PubMed ID: 11306609
    [Abstract] [Full Text] [Related]

  • 19. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures.
    Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells JM, McKee A, Ullman MD, Fine RE.
    J Neurosci Res; 2006 May 15; 83(7):1262-70. PubMed ID: 16511862
    [Abstract] [Full Text] [Related]

  • 20. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention.
    Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD.
    Neurobiol Aging; 2011 Nov 15; 32(11):1949-63. PubMed ID: 20053478
    [Abstract] [Full Text] [Related]

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