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Journal Abstract Search

131 related items for PubMed ID: 10706409

  • 1. Characterization of microsomal alcohol oxygenase catalyzing the oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in rat liver.
    Matsunaga T, Shibayama K, Higuchi S, Tanaka H, Watanabe K, Yamamoto I.
    Biol Pharm Bull; 2000 Jan; 23(1):43-6. PubMed ID: 10706409
    [Abstract] [Full Text] [Related]

  • 2. Monkey hepatic microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 enzyme catalyzing the stereoselective oxidation of 7alpha- and 7beta-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.
    Matsunaga T, Iwawaki Y, Komura A, Watanabe K, Kageyama T, Yamamoto I.
    Biol Pharm Bull; 2002 Jan; 25(1):42-7. PubMed ID: 11824554
    [Abstract] [Full Text] [Related]

  • 3. Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7beta-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol in monkey liver microsomes.
    Funahashi T, Tanaka Y, Yamaori S, Kimura T, Matsunaga T, Ohmori S, Kageyama T, Yamamoto I, Watanabe K.
    Drug Metab Pharmacokinet; 2005 Oct; 20(5):358-67. PubMed ID: 16272754
    [Abstract] [Full Text] [Related]

  • 4. CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes.
    Matsunaga T, Kishi N, Higuchi S, Watanabe K, Ohshima T, Yamamoto I.
    Drug Metab Dispos; 2000 Nov; 28(11):1291-6. PubMed ID: 11038155
    [Abstract] [Full Text] [Related]

  • 5. Major cytochrome P450 enzyme responsible for oxidation of secondary alcohols to the corresponding ketones in mouse hepatic microsomes. Oxidation of 7-hydroxy-delta8-tetrahydrocannabinol to 7-oxo-delta8-tetrahydrocannabinol.
    Matsunaga T, Kishi N, Tanaka H, Watanabe K, Yoshimura H, Yamamoto I.
    Drug Metab Dispos; 1998 Oct; 26(10):1045-7. PubMed ID: 9763413
    [Abstract] [Full Text] [Related]

  • 6. Microsomal alcohol oxygenase: purification and characterization of a cytochrome P450 responsible for oxidation of 7-hydroxy-delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol in guinea pig liver.
    Matsunaga T, Tanaka H, Komura A, Watanabe K, Yamamoto I, Yoshimura H.
    Arch Biochem Biophys; 1997 Dec 01; 348(1):56-64. PubMed ID: 9390174
    [Abstract] [Full Text] [Related]

  • 7. Effective NADH-dependent oxidation of 7beta-hydroxy-delta8-tetrahydrocannabinol to the corresponding ketone by Japanese monkey hepatic microsomes.
    Matsunaga T, Higuchi S, Watanabe K, Kageyama T, Ohmori S, Yamamoto I.
    Biol Pharm Bull; 2005 Apr 01; 28(4):646-51. PubMed ID: 15802803
    [Abstract] [Full Text] [Related]

  • 8. Catalytic activity of cytochrome P450 isozymes purified from rat liver in converting 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Imaoka S, Funae Y, Yoshimura H.
    Biochem Pharmacol; 1991 Aug 22; 42(6):1255-9. PubMed ID: 1653566
    [Abstract] [Full Text] [Related]

  • 9. Oxidation mechanism of 7-hydroxy-delta 8-tetrahydrocannabinol and 8-hydroxy-delta 9-tetrahydrocannabinol to the corresponding ketones by CYP3A11.
    Matsunaga T, Tanaka H, Higuchi S, Shibayama K, Kishi N, Watanabe K, Yamamoto I.
    Drug Metab Dispos; 2001 Nov 22; 29(11):1485-91. PubMed ID: 11602526
    [Abstract] [Full Text] [Related]

  • 10. Mechanism of hepatic microsomal oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol. Evidence for hydration of the aldehyde formed.
    Watanabe K, Matsunaga T, Narimatsu S, Yamamoto I, Yoshimura H.
    J Pharmacobiodyn; 1992 Jun 22; 15(6):311-7. PubMed ID: 1331394
    [Abstract] [Full Text] [Related]

  • 11. Microsomal oxygenase catalyzed oxidation of 11-hydroxy-delta 8-tetrahydrocannabinol to 11-oxo-delta 8-tetrahydrocannabinol.
    Watanabe K, Yamamoto I, Oguri K, Yoshimura H.
    Biochem Biophys Res Commun; 1979 May 14; 88(1):178-82. PubMed ID: 36896
    [No Abstract] [Full Text] [Related]

  • 12. A cytochrome P450 isozyme having aldehyde oxygenase activity plays a major role in metabolizing cannabinoids by mouse hepatic microsomes.
    Watanabe K, Narimatsu S, Matsunaga T, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1993 Aug 03; 46(3):405-11. PubMed ID: 8394082
    [Abstract] [Full Text] [Related]

  • 13. Cytochrome P-450 isozymes involved in the oxidative metabolism of delta 9-tetrahydrocannabinol by liver microsomes of adult female rats.
    Narimatsu S, Watanabe K, Matsunaga T, Yamamoto I, Imaoka S, Funae Y, Yoshimura H.
    Drug Metab Dispos; 1992 Aug 03; 20(1):79-83. PubMed ID: 1347001
    [Abstract] [Full Text] [Related]

  • 14. Immunochemical characterization of a cytochrome P450 isozyme and a protein purified from liver microsomes of male guinea pigs and their roles in the oxidative metabolism of delta 9-tetrahydrocannabinol by guinea pig liver microsomes.
    Narimatsu S, Akutsu Y, Matsunaga T, Watanabe K, Yamamoto I, Yoshimura H.
    Biochem Pharmacol; 1992 Apr 15; 43(8):1729-36. PubMed ID: 1315542
    [Abstract] [Full Text] [Related]

  • 15. Identification and determination of 11-oxo-delta8-tetrahydrocannabinol as an intermediate metabolite of delta8-tetrahydrocannabinol in the mouse brain and liver.
    Watanabe K, Yamamoto I, Oguri K, Yoshimura H.
    J Pharmacobiodyn; 1980 Dec 15; 3(12):686-91. PubMed ID: 6268770
    [Abstract] [Full Text] [Related]

  • 16. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.
    Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I.
    Life Sci; 2007 Mar 20; 80(15):1415-9. PubMed ID: 17303175
    [Abstract] [Full Text] [Related]

  • 17. Enzymatic oxidation of 7-hydroxylated delta 8-tetrahydrocannabinol to 7-oxo-delta 8-tetrahydrocannabinol by hepatic microsomes of the guinea pig.
    Narimatsu S, Matsubara K, Shimonishi T, Watanabe K, Yamamoto I, Yoshimura H.
    Drug Metab Dispos; 1988 Mar 20; 16(1):156-61. PubMed ID: 2894947
    [Abstract] [Full Text] [Related]

  • 18. Mouse hepatic microsomal enzyme that catalyzes oxidation of 11-oxo-delta 8-tetrahydrocannabinol to delta 8-tetrahydrocannabinol-11-oic acid.
    Watanabe K, Hirahashi N, Narimatsu S, Yamamoto I, Yoshimura H.
    Drug Metab Dispos; 1991 Mar 20; 19(1):218-21. PubMed ID: 1673402
    [Abstract] [Full Text] [Related]

  • 19. Human hepatic microsomal metabolism of delta 1-tetrahydrocannabinol.
    Bornheim LM, Lasker JM, Raucy JL.
    Drug Metab Dispos; 1992 Mar 20; 20(2):241-6. PubMed ID: 1352216
    [Abstract] [Full Text] [Related]

  • 20. In vitro and in vivo interactions of delta 8-tetra-hydrocannabinol and its metabolites with hepatic microsomal drug metabolizing enzyme systems of mice.
    Watanabe K, Yamamoto I, Oguri K, Yoshimura H.
    J Pharmacobiodyn; 1981 Aug 20; 4(8):604-11. PubMed ID: 6271944
    [Abstract] [Full Text] [Related]

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