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245 related items for PubMed ID: 10722687

  • 1. Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products.
    Thuresson ED, Lakkides KM, Smith WL.
    J Biol Chem; 2000 Mar 24; 275(12):8501-7. PubMed ID: 10722687
    [Abstract] [Full Text] [Related]

  • 2. PGG2, 11R-HPETE and 15R/S-HPETE are formed from different conformers of arachidonic acid in the prostaglandin endoperoxide H synthase-1 cyclooxygenase site.
    Thuresson ED, Lakkides KM, Smith WL.
    Adv Exp Med Biol; 2002 Mar 24; 507():67-72. PubMed ID: 12664566
    [No Abstract] [Full Text] [Related]

  • 3. Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
    Harman CA, Rieke CJ, Garavito RM, Smith WL.
    J Biol Chem; 2004 Oct 08; 279(41):42929-35. PubMed ID: 15292194
    [Abstract] [Full Text] [Related]

  • 4. Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.
    Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL.
    J Biol Chem; 2001 Mar 30; 276(13):10347-57. PubMed ID: 11121412
    [Abstract] [Full Text] [Related]

  • 5. Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete.
    Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ.
    J Biol Chem; 2000 Mar 03; 275(9):6586-91. PubMed ID: 10692466
    [Abstract] [Full Text] [Related]

  • 6. Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site.
    Schneider C, Brash AR.
    J Biol Chem; 2000 Feb 18; 275(7):4743-6. PubMed ID: 10671506
    [Abstract] [Full Text] [Related]

  • 7. Identification of novel arachidonic acid metabolites formed by prostaglandin H synthase.
    Hecker M, Ullrich V, Fischer C, Meese CO.
    Eur J Biochem; 1987 Nov 16; 169(1):113-23. PubMed ID: 3119336
    [Abstract] [Full Text] [Related]

  • 8. The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors.
    Rieke CJ, Mulichak AM, Garavito RM, Smith WL.
    J Biol Chem; 1999 Jun 11; 274(24):17109-14. PubMed ID: 10358065
    [Abstract] [Full Text] [Related]

  • 9. Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis.
    Schneider C, Boeglin WE, Brash AR.
    J Biol Chem; 2004 Feb 06; 279(6):4404-14. PubMed ID: 14594816
    [Abstract] [Full Text] [Related]

  • 10. Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand.
    Seibold SA, Cerda JF, Mulichak AM, Song I, Garavito RM, Arakawa T, Smith WL, Babcock GT.
    Biochemistry; 2000 Jun 06; 39(22):6616-24. PubMed ID: 10828979
    [Abstract] [Full Text] [Related]

  • 11. On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.
    Burde T, Rimon G.
    Eur J Pharmacol; 2002 Oct 25; 453(2-3):167-73. PubMed ID: 12398900
    [Abstract] [Full Text] [Related]

  • 12. Different suicide inactivation processes for the peroxidase and cyclooxygenase activities of prostaglandin endoperoxide H synthase-1.
    Song I, Ball TM, Smith WL.
    Biochem Biophys Res Commun; 2001 Dec 14; 289(4):869-75. PubMed ID: 11735127
    [Abstract] [Full Text] [Related]

  • 13. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.
    Lecomte M, Laneuville O, Ji C, DeWitt DL, Smith WL.
    J Biol Chem; 1994 May 06; 269(18):13207-15. PubMed ID: 8175750
    [Abstract] [Full Text] [Related]

  • 14. Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.
    Malkowski MG, Thuresson ED, Lakkides KM, Rieke CJ, Micielli R, Smith WL, Garavito RM.
    J Biol Chem; 2001 Oct 05; 276(40):37547-55. PubMed ID: 11477109
    [Abstract] [Full Text] [Related]

  • 15. Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites.
    Hecker M, Hatzelmann A, Ullrich V.
    Biochem Pharmacol; 1987 Mar 15; 36(6):851-5. PubMed ID: 3105538
    [Abstract] [Full Text] [Related]

  • 16. The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.
    DeWitt DL, el-Harith EA, Kraemer SA, Andrews MJ, Yao EF, Armstrong RL, Smith WL.
    J Biol Chem; 1990 Mar 25; 265(9):5192-8. PubMed ID: 2108169
    [Abstract] [Full Text] [Related]

  • 17. The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis.
    Spencer AG, Thuresson E, Otto JC, Song I, Smith T, DeWitt DL, Garavito RM, Smith WL.
    J Biol Chem; 1999 Nov 12; 274(46):32936-42. PubMed ID: 10551860
    [Abstract] [Full Text] [Related]

  • 18. Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
    Bhattacharyya DK, Lecomte M, Rieke CJ, Garavito M, Smith WL.
    J Biol Chem; 1996 Jan 26; 271(4):2179-84. PubMed ID: 8567676
    [Abstract] [Full Text] [Related]

  • 19. Formation of 11-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid in human umbilical arteries is catalyzed by cyclooxygenase.
    Setty BN, Stuart MJ, Walenga RW.
    Biochim Biophys Acta; 1985 Mar 06; 833(3):484-94. PubMed ID: 3918580
    [Abstract] [Full Text] [Related]

  • 20. C-terminal Ser/Pro-Thr-Glu-Leu tetrapeptides of prostaglandin endoperoxide H synthases-1 and -2 target the enzymes to the endoplasmic reticulum.
    Song I, Smith WL.
    Arch Biochem Biophys; 1996 Oct 01; 334(1):67-72. PubMed ID: 8837740
    [Abstract] [Full Text] [Related]

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