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PUBMED FOR HANDHELDS

Journal Abstract Search


117 related items for PubMed ID: 10737758

  • 1. Methyl-substituted dispiro-1,2,4,5-tetraoxanes: correlations of structural studies with antimalarial activity.
    McCullough KJ, Wood JK, Bhattacharjee AK, Dong Y, Kyle DE, Milhous WK, Vennerstrom JL.
    J Med Chem; 2000 Mar 23; 43(6):1246-9. PubMed ID: 10737758
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
    Vennerstrom JL, Dong Y, Andersen SL, Ager AL, Fu H, Miller RE, Wesche DL, Kyle DE, Gerena L, Walters SM, Wood JK, Edwards G, Holme AD, McLean WG, Milhous WK.
    J Med Chem; 2000 Jul 13; 43(14):2753-8. PubMed ID: 10893313
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  • 3. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
    Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL.
    J Med Chem; 1999 Apr 22; 42(8):1477-80. PubMed ID: 10212135
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  • 4. The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone.
    Dong Y, McCullough KJ, Wittlin S, Chollet J, Vennerstrom JL.
    Bioorg Med Chem Lett; 2010 Nov 15; 20(22):6359-61. PubMed ID: 20943385
    [Abstract] [Full Text] [Related]

  • 5. Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
    Ellis GL, Amewu R, Sabbani S, Stocks PA, Shone A, Stanford D, Gibbons P, Davies J, Vivas L, Charnaud S, Bongard E, Hall C, Rimmer K, Lozanom S, Jesús M, Gargallo D, Ward SA, O'Neill PM.
    J Med Chem; 2008 Apr 10; 51(7):2170-7. PubMed ID: 18341274
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  • 6. Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes.
    Kumar N, Khan SI, Beena, Rajalakshmi G, Kumaradhas P, Rawat DS.
    Bioorg Med Chem; 2009 Aug 01; 17(15):5632-8. PubMed ID: 19574054
    [Abstract] [Full Text] [Related]

  • 7. Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
    Bousejra-El Garah F, Wong MH, Amewu RK, Muangnoicharoen S, Maggs JL, Stigliani JL, Park BK, Chadwick J, Ward SA, O'Neill PM.
    J Med Chem; 2011 Oct 13; 54(19):6443-55. PubMed ID: 21888440
    [Abstract] [Full Text] [Related]

  • 8. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
    Vennerstrom JL, Fu HN, Ellis WY, Ager AL, Wood JK, Andersen SL, Gerena L, Milhous WK.
    J Med Chem; 1992 Aug 07; 35(16):3023-7. PubMed ID: 1501229
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  • 10. Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
    O'Neill PM, Amewu RK, Nixon GL, Bousejra ElGarah F, Mungthin M, Chadwick J, Shone AE, Vivas L, Lander H, Barton V, Muangnoicharoen S, Bray PG, Davies J, Park BK, Wittlin S, Brun R, Preschel M, Zhang K, Ward SA.
    Angew Chem Int Ed Engl; 2010 Aug 02; 49(33):5693-7. PubMed ID: 20629058
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  • 12. Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity.
    Solaja BA, Terzić N, Pocsfalvi G, Gerena L, Tinant B, Opsenica D, Milhous WK.
    J Med Chem; 2002 Aug 01; 45(16):3331-6. PubMed ID: 12139444
    [Abstract] [Full Text] [Related]

  • 13. Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
    Wang X, Dong Y, Wittlin S, Charman SA, Chiu FC, Chollet J, Katneni K, Mannila J, Morizzi J, Ryan E, Scheurer C, Steuten J, Santo Tomas J, Snyder C, Vennerstrom JL.
    J Med Chem; 2013 Mar 28; 56(6):2547-55. PubMed ID: 23489135
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  • 16. Cholic acid derivatives as 1,2,4,5-tetraoxane carriers: structure and antimalarial and antiproliferative activity.
    Opsenica D, Pocsfalvi G, Juranic Z, Tinant B, Declercq JP, Kyle DE, Milhous WK, Solaja BA.
    J Med Chem; 2000 Aug 24; 43(17):3274-82. PubMed ID: 10966746
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  • 18. 1,2,4,5-Tetraoxane derivatives/hybrids as potent antimalarial endoperoxides: Chronological advancements, structure-activity relationship (SAR) studies and future perspectives.
    T A AR, Rajendra TN, Suhas KP, Ippagunta SK, Chaudhary S.
    Med Res Rev; 2024 Sep 24; 44(5):2266-2290. PubMed ID: 38618882
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  • 20. Tetraoxane antimalarials and their reaction with Fe(II).
    Opsenica I, Terzić N, Opsenica D, Angelovski G, Lehnig M, Eilbracht P, Tinant B, Juranić Z, Smith KS, Yang YS, Diaz DS, Smith PL, Milhous WK, Doković D, Solaja BA.
    J Med Chem; 2006 Jun 29; 49(13):3790-9. PubMed ID: 16789736
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