These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

248 related items for PubMed ID: 10753902

  • 1. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
    Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR.
    J Biol Chem; 2000 Apr 14; 275(15):11002-9. PubMed ID: 10753902
    [Abstract] [Full Text] [Related]

  • 2. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
    Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK.
    Antimicrob Agents Chemother; 2006 Jun 14; 50(6):2178-84. PubMed ID: 16723580
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
    Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR.
    Biochemistry; 2007 Mar 27; 46(12):3793-802. PubMed ID: 17335290
    [Abstract] [Full Text] [Related]

  • 4. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 1999 Feb 09; 38(6):1902-11. PubMed ID: 10026271
    [Abstract] [Full Text] [Related]

  • 5. Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
    Barb AW, Zhou P.
    Curr Pharm Biotechnol; 2008 Feb 09; 9(1):9-15. PubMed ID: 18289052
    [Abstract] [Full Text] [Related]

  • 6. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 2001 Jan 16; 40(2):514-23. PubMed ID: 11148046
    [Abstract] [Full Text] [Related]

  • 7. A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.
    McClerren AL, Endsley S, Bowman JL, Andersen NH, Guan Z, Rudolph J, Raetz CR.
    Biochemistry; 2005 Dec 20; 44(50):16574-83. PubMed ID: 16342948
    [Abstract] [Full Text] [Related]

  • 8. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.
    Bioorg Med Chem Lett; 2013 Apr 15; 23(8):2362-7. PubMed ID: 23499237
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.
    Pirrung MC, Tumey LN, Raetz CR, Jackman JE, Snehalatha K, McClerren AL, Fierke CA, Gantt SL, Rusche KM.
    J Med Chem; 2002 Sep 12; 45(19):4359-70. PubMed ID: 12213077
    [Abstract] [Full Text] [Related]

  • 10. Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 12; 45(49):14573-81. PubMed ID: 17144651
    [Abstract] [Full Text] [Related]

  • 11. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) inhibitors: a new class of antibacterial agents.
    Zhang J, Zhang L, Li X, Xu W.
    Curr Med Chem; 2012 Dec 12; 19(13):2038-50. PubMed ID: 22414079
    [Abstract] [Full Text] [Related]

  • 12. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
    Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW.
    Proc Natl Acad Sci U S A; 2003 Jul 08; 100(14):8146-50. PubMed ID: 12819349
    [Abstract] [Full Text] [Related]

  • 13. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
    Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P.
    Nat Struct Biol; 2003 Aug 08; 10(8):645-51. PubMed ID: 12833153
    [Abstract] [Full Text] [Related]

  • 14. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
    McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J.
    Biochemistry; 2005 Feb 01; 44(4):1106-13. PubMed ID: 15667204
    [Abstract] [Full Text] [Related]

  • 15. Structure of the metal-dependent deacetylase LpxC from Yersinia enterocolitica complexed with the potent inhibitor CHIR-090 .
    Cole KE, Gattis SG, Angell HD, Fierke CA, Christianson DW.
    Biochemistry; 2011 Jan 18; 50(2):258-65. PubMed ID: 21171638
    [Abstract] [Full Text] [Related]

  • 16. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466.
    Cuny GD.
    Expert Opin Ther Pat; 2009 Jun 18; 19(6):893-9. PubMed ID: 19473108
    [Abstract] [Full Text] [Related]

  • 17. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.
    Gattis SG, Hernick M, Fierke CA.
    J Biol Chem; 2010 Oct 29; 285(44):33788-96. PubMed ID: 20709752
    [Abstract] [Full Text] [Related]

  • 18. Recent Process in the Inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine Deacetylase (LpxC) Against Gram-Negative Bacteria.
    Liu F, Ma S.
    Mini Rev Med Chem; 2018 Oct 29; 18(4):310-323. PubMed ID: 27739357
    [Abstract] [Full Text] [Related]

  • 19. Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis.
    Chen MH, Steiner MG, de Laszlo SE, Patchett AA, Anderson MS, Hyland SA, Onishi HR, Silver LL, Raetz CR.
    Bioorg Med Chem Lett; 1999 Feb 08; 9(3):313-8. PubMed ID: 10091675
    [Abstract] [Full Text] [Related]

  • 20. Antibacterial activities and characterization of novel inhibitors of LpxC.
    Clements JM, Coignard F, Johnson I, Chandler S, Palan S, Waller A, Wijkmans J, Hunter MG.
    Antimicrob Agents Chemother; 2002 Jun 08; 46(6):1793-9. PubMed ID: 12019092
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 13.