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267 related items for PubMed ID: 10764150

  • 1. Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism.
    Hoyle PE, Moye PW, Steelman LS, Blalock WL, Franklin RA, Pearce M, Cherwinski H, Bosch E, McMahon M, McCubrey JA.
    Leukemia; 2000 Apr; 14(4):642-56. PubMed ID: 10764150
    [Abstract] [Full Text] [Related]

  • 2. Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells.
    McCubrey JA, Steelman LS, Hoyle PE, Blalock WL, Weinstein-Oppenheimer C, Franklin RA, Cherwinski H, Bosch E, McMahon M.
    Leukemia; 1998 Dec; 12(12):1903-29. PubMed ID: 9844921
    [Abstract] [Full Text] [Related]

  • 3. Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells.
    Weinstein-Oppenheimer C, Steelman LS, Algate PA, Blalock WL, Burrows C, Hoyle PE, Lee JT, Moye PW, Shelton JG, Franklin R, McCubrey JA.
    Leukemia; 2000 Nov; 14(11):1921-38. PubMed ID: 11069028
    [Abstract] [Full Text] [Related]

  • 4. A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.
    Blalock WL, Pearce M, Steelman LS, Franklin RA, McCarthy SA, Cherwinski H, McMahon M, McCubrey JA.
    Oncogene; 2000 Jan 27; 19(4):526-36. PubMed ID: 10698522
    [Abstract] [Full Text] [Related]

  • 5. Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
    Blalock WL, Moye PW, Chang F, Pearce M, Steelman LS, McMahon M, McCubrey JA.
    Leukemia; 2000 Jun 27; 14(6):1080-96. PubMed ID: 10865974
    [Abstract] [Full Text] [Related]

  • 6. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.
    Shelton JG, Moye PW, Steelman LS, Blalock WL, Lee JT, Franklin RA, McMahon M, McCubrey JA.
    Leukemia; 2003 Sep 27; 17(9):1765-82. PubMed ID: 12970777
    [Abstract] [Full Text] [Related]

  • 7. Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells.
    Blalock WL, Pearce M, Chang F, Lee JT, Pohnert SC, Burrows C, Steelman LS, Franklin RA, McMahon M, McCubrey JA.
    Leukemia; 2001 May 27; 15(5):794-807. PubMed ID: 11368441
    [Abstract] [Full Text] [Related]

  • 8. Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells.
    Konopleva M, Shi Y, Steelman LS, Shelton JG, Munsell M, Marini F, McQueen T, Contractor R, McCubrey JA, Andreeff M.
    Cancer Res; 2005 Nov 01; 65(21):9962-70. PubMed ID: 16267021
    [Abstract] [Full Text] [Related]

  • 9. Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
    Moye PW, Blalock WL, Hoyle PE, Chang F, Franklin RA, Weinstein-Oppenheimer C, Pearce M, Steelman L, McMahon M, McCubrey JA.
    Leukemia; 2000 Jun 01; 14(6):1060-79. PubMed ID: 10865973
    [Abstract] [Full Text] [Related]

  • 10. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
    Blalock WL, Navolanic PM, Steelman LS, Shelton JG, Moye PW, Lee JT, Franklin RA, Mirza A, McMahon M, White MK, McCubrey JA.
    Leukemia; 2003 Jun 01; 17(6):1058-67. PubMed ID: 12764369
    [Abstract] [Full Text] [Related]

  • 11. Ability of the activated PI3K/Akt oncoproteins to synergize with MEK1 and induce cell cycle progression and abrogate the cytokine-dependence of hematopoietic cells.
    Shelton JG, Blalock WL, White ER, Steelman LS, McCubrey JA.
    Cell Cycle; 2004 Apr 01; 3(4):503-12. PubMed ID: 15004527
    [Abstract] [Full Text] [Related]

  • 12. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.
    Hambleton J, McMahon M, DeFranco AL.
    J Exp Med; 1995 Jul 01; 182(1):147-54. PubMed ID: 7790814
    [Abstract] [Full Text] [Related]

  • 13. Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.
    McCubrey JA, Lee JT, Steelman LS, Blalock WL, Moye PW, Chang F, Pearce M, Shelton JG, White MK, Franklin RA, Pohnert SC.
    Cancer Detect Prev; 2001 Jul 01; 25(4):375-93. PubMed ID: 11531015
    [Abstract] [Full Text] [Related]

  • 14. Mutations of critical amino acids affect the biological and biochemical properties of oncogenic A-Raf and Raf-1.
    Bosch E, Cherwinski H, Peterson D, McMahon M.
    Oncogene; 1997 Aug 28; 15(9):1021-33. PubMed ID: 9285556
    [Abstract] [Full Text] [Related]

  • 15. Raf-induced cell cycle progression in human TF-1 hematopoietic cells.
    Chang F, Steelman LS, McCubrey JA.
    Cell Cycle; 2002 Aug 28; 1(3):220-6. PubMed ID: 12429936
    [Abstract] [Full Text] [Related]

  • 16. Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
    Kuo WL, Abe M, Rhee J, Eves EM, McCarthy SA, Yan M, Templeton DJ, McMahon M, Rosner MR.
    Mol Cell Biol; 1996 Apr 28; 16(4):1458-70. PubMed ID: 8657119
    [Abstract] [Full Text] [Related]

  • 17. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells.
    Pritchard CA, Samuels ML, Bosch E, McMahon M.
    Mol Cell Biol; 1995 Nov 28; 15(11):6430-42. PubMed ID: 7565795
    [Abstract] [Full Text] [Related]

  • 18. P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
    Chang F, McCubrey JA.
    Oncogene; 2001 Jul 19; 20(32):4354-64. PubMed ID: 11466616
    [Abstract] [Full Text] [Related]

  • 19. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.
    Tyagi A, Agarwal R, Agarwal C.
    Oncogene; 2003 Mar 06; 22(9):1302-16. PubMed ID: 12618755
    [Abstract] [Full Text] [Related]

  • 20. B-raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells.
    Shelton JG, Chang F, Lee JT, Franklin RA, Steelman LS, McCubrey JA.
    Cell Cycle; 2004 Feb 06; 3(2):189-96. PubMed ID: 14712088
    [Abstract] [Full Text] [Related]

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