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177 related items for PubMed ID: 10856427

  • 1. Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3.
    Giorgianni F, Bridson PK, Sorrentino BP, Pohl J, Blakley RL.
    Biochem Pharmacol; 2000 Aug 01; 60(3):325-38. PubMed ID: 10856427
    [Abstract] [Full Text] [Related]

  • 2. Potentiation of the cytotoxic action of mafosfamide by N-isopropyl-p-formylbenzamide, a metabolite of procarbazine.
    Maki PA, Sladek NE.
    Cancer Res; 1991 Aug 15; 51(16):4170-5. PubMed ID: 1868438
    [Abstract] [Full Text] [Related]

  • 3. Kinetic characterization of the catalysis of "activated" cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases.
    Manthey CL, Sladek NE.
    Biochem Pharmacol; 1988 Jul 15; 37(14):2781-90. PubMed ID: 3395357
    [Abstract] [Full Text] [Related]

  • 4. Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.
    Kohn FR, Landkamer GJ, Manthey CL, Ramsay NK, Sladek NE.
    Cancer Res; 1987 Jun 15; 47(12):3180-5. PubMed ID: 3034402
    [Abstract] [Full Text] [Related]

  • 5. Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes.
    von Eitzen U, Meier-Tackmann D, Agarwal DP, Goedde HW.
    Cancer Lett; 1994 Jan 15; 76(1):45-9. PubMed ID: 8124665
    [Abstract] [Full Text] [Related]

  • 6. Effects of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of murine late spleen colony-forming cells (day-12 CFU-S) and hematopoietic repopulating cells to mafosfamide (ASTA Z 7557).
    Kohn FR, Sladek NE.
    Biochem Pharmacol; 1987 Sep 01; 36(17):2805-11. PubMed ID: 2820422
    [Abstract] [Full Text] [Related]

  • 7. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde.
    Dockham PA, Lee MO, Sladek NE.
    Biochem Pharmacol; 1992 Jun 09; 43(11):2453-69. PubMed ID: 1610409
    [Abstract] [Full Text] [Related]

  • 8. Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines.
    Kohn FR, Sladek NE.
    Biochem Pharmacol; 1985 Oct 01; 34(19):3465-71. PubMed ID: 2996550
    [Abstract] [Full Text] [Related]

  • 9. Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme.
    Bunting KD, Townsend AJ.
    J Biol Chem; 1996 May 17; 271(20):11891-6. PubMed ID: 8662659
    [Abstract] [Full Text] [Related]

  • 10. Identification of the mouse aldehyde dehydrogenases important in aldophosphamide detoxification.
    Manthey CL, Landkamer GJ, Sladek NE.
    Cancer Res; 1990 Aug 15; 50(16):4991-5002. PubMed ID: 2379164
    [Abstract] [Full Text] [Related]

  • 11. Enhanced expressions of glucose-6-phosphate dehydrogenase and cytosolic aldehyde dehydrogenase and elevation of reduced glutathione level in cyclophosphamide-resistant human leukemia cells.
    Tsukamoto N, Chen J, Yoshida A.
    Blood Cells Mol Dis; 1998 Jun 15; 24(2):231-8. PubMed ID: 9714700
    [Abstract] [Full Text] [Related]

  • 12. Intrinsic cellular resistance to oxazaphosphorines exhibited by a human colon carcinoma cell line expressing relatively large amounts of a class-3 aldehyde dehydrogenase.
    Rekha GK, Sreerama L, Sladek NE.
    Biochem Pharmacol; 1994 Nov 16; 48(10):1943-52. PubMed ID: 7986206
    [Abstract] [Full Text] [Related]

  • 13. Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines.
    Dockham PA, Sreerama L, Sladek NE.
    Drug Metab Dispos; 1997 Dec 16; 25(12):1436-41. PubMed ID: 9394035
    [Abstract] [Full Text] [Related]

  • 14. Human breast adenocarcinoma MCF-7/0 cells electroporated with cytosolic class 3 aldehyde dehydrogenases obtained from tumor cells and a normal tissue exhibit differential sensitivity to mafosfamide.
    Sreerama L, Sladek NE.
    Drug Metab Dispos; 1995 Oct 16; 23(10):1080-4. PubMed ID: 8654195
    [Abstract] [Full Text] [Related]

  • 15. De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
    Bunting KD, Townsend AJ.
    J Biol Chem; 1996 May 17; 271(20):11884-90. PubMed ID: 8662658
    [Abstract] [Full Text] [Related]

  • 16. Sensitivity of aldehyde dehydrogenases in murine tumor and hematopoietic progenitor cells to inhibition by chloral hydrate as determined by the ability of chloral hydrate to potentiate the cytotoxic action of mafosfamide.
    Maki PA, Sladek NE.
    Biochem Pharmacol; 1993 Jan 07; 45(1):231-9. PubMed ID: 8424816
    [Abstract] [Full Text] [Related]

  • 17. NADPH-dependent enzyme-catalyzed reduction of aldophosphamide, the pivotal metabolite of cyclophosphamide.
    Parekh HK, Sladek NE.
    Biochem Pharmacol; 1993 Sep 14; 46(6):1043-52. PubMed ID: 8216347
    [Abstract] [Full Text] [Related]

  • 18. Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer.
    Magni M, Shammah S, Schiró R, Mellado W, Dalla-Favera R, Gianni AM.
    Blood; 1996 Feb 01; 87(3):1097-103. PubMed ID: 8562935
    [Abstract] [Full Text] [Related]

  • 19. Interaction of human aldehyde dehydrogenase with aromatic substrates and ligands.
    Allali-Hassani A, Weiner H.
    Chem Biol Interact; 2001 Jan 30; 130-132(1-3):125-33. PubMed ID: 11306037
    [Abstract] [Full Text] [Related]

  • 20. Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.
    Bunting KD, Lindahl R, Townsend AJ.
    J Biol Chem; 1994 Sep 16; 269(37):23197-203. PubMed ID: 8083225
    [Abstract] [Full Text] [Related]

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