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116 related items for PubMed ID: 10884579

  • 1. Kinetics of hydrolysis of dextran-methylprednisolone succinate, a macromolecular prodrug of methylprednisolone, in rat blood and liver lysosomes.
    Mehvar R, Dann RO, Hoganson DA.
    J Control Release; 2000 Jul 31; 68(1):53-61. PubMed ID: 10884579
    [Abstract] [Full Text] [Related]

  • 2. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: plasma and tissue disposition.
    Zhang X, Mehvar R.
    J Pharm Sci; 2001 Dec 31; 90(12):2078-87. PubMed ID: 11745766
    [Abstract] [Full Text] [Related]

  • 3. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: immunosuppressive effects after in vivo administration to rats.
    Mehvar R, Hoganson DA.
    Pharm Res; 2000 Nov 31; 17(11):1402-7. PubMed ID: 11205734
    [Abstract] [Full Text] [Related]

  • 4. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: dose-dependent pharmacokinetics in rats.
    Zhang X, Mehvar R.
    Int J Pharm; 2001 Oct 23; 229(1-2):173-82. PubMed ID: 11604270
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and in vitro characterization of novel dextran-methylprednisolone conjugates with peptide linkers: effects of linker length on hydrolytic and enzymatic release of methylprednisolone and its peptidyl intermediates.
    Penugonda S, Kumar A, Agarwal HK, Parang K, Mehvar R.
    J Pharm Sci; 2008 Jul 23; 97(7):2649-64. PubMed ID: 17853426
    [Abstract] [Full Text] [Related]

  • 6. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: local immunosuppressive effects in liver after systemic administration to rats.
    Chimalakonda AP, Mehvar R.
    Pharm Res; 2003 Feb 23; 20(2):198-204. PubMed ID: 12636157
    [Abstract] [Full Text] [Related]

  • 7. Plasma pharmacokinetics and tissue disposition of novel dextran-methylprednisolone conjugates with peptide linkers in rats.
    Penugonda S, Agarwal HK, Parang K, Mehvar R.
    J Pharm Sci; 2010 Mar 23; 99(3):1626-37. PubMed ID: 19780131
    [Abstract] [Full Text] [Related]

  • 8. Effects of duration of ischemia and donor pretreatment with methylprednisolone or its macromolecular prodrug on the disposition of indocyanine green in cold-preserved rat livers.
    Chimalakonda AP, Mehvar R.
    Pharm Res; 2004 Jun 23; 21(6):1000-8. PubMed ID: 15212166
    [Abstract] [Full Text] [Related]

  • 9. High-performance size-exclusion chromatographic analysis of dextran-methylprednisolone hemisuccinate in rat plasma.
    Mehvar R.
    J Chromatogr B Biomed Sci Appl; 2000 Jul 21; 744(2):293-8. PubMed ID: 10993517
    [Abstract] [Full Text] [Related]

  • 10. Disposition of methylprednisolone and its sodium succinate prodrug in vivo and in perfused liver of rats: nonlinear and sequential first-pass elimination.
    Kong AN, Jusko WJ.
    J Pharm Sci; 1991 May 21; 80(5):409-15. PubMed ID: 1880717
    [Abstract] [Full Text] [Related]

  • 11. Dextran-methylprednisolone succinate as a prodrug of methylprednisolone: in vitro immunosuppressive effects on rat blood and spleen lymphocytes.
    Rensberger KL, Hoganson DA, Mehvar R.
    Int J Pharm; 2000 Oct 10; 207(1-2):71-6. PubMed ID: 11036232
    [Abstract] [Full Text] [Related]

  • 12. Attenuation of Kupffer cell activation in cold-preserved livers after pretreatment of rats with methylprednisolone or its macromolecular prodrug.
    Chimalakonda AP, Mehvar R.
    Pharm Res; 2003 Jul 10; 20(7):1001-8. PubMed ID: 12880285
    [Abstract] [Full Text] [Related]

  • 13. Simultaneous analysis of methylprednisolone, methylprednisolone succinate, and endogenous corticosterone in rat plasma.
    Mehvar R, Dann RO, Hoganson DA.
    J Pharm Biomed Anal; 2000 Jul 10; 22(6):1015-22. PubMed ID: 10857570
    [Abstract] [Full Text] [Related]

  • 14. Hepatic immunosuppressive effects of systemically administered novel dextran-methylprednisolone prodrugs with peptide linkers in rats.
    Shaik IH, Agarwal HK, Parang K, Mehvar R.
    J Pharm Sci; 2012 Oct 10; 101(10):4003-12. PubMed ID: 22829462
    [Abstract] [Full Text] [Related]

  • 15. A comparative population pharmacokinetic analysis for methylprednisolone following multiple dosing of two prodrugs in patients with acute asthma.
    Parker TJ, Daley-Yates PT, Wood SA.
    Br J Clin Pharmacol; 1997 Jun 10; 43(6):589-92. PubMed ID: 9205818
    [Abstract] [Full Text] [Related]

  • 16. Effects of methylprednisolone and its liver-targeted dextran prodrug on ischemia-reperfusion injury in a rat liver transplantation model.
    Chimalakonda AP, Mehvar R.
    Pharm Res; 2007 Dec 10; 24(12):2231-8. PubMed ID: 17922174
    [Abstract] [Full Text] [Related]

  • 17. Attenuation of acute rejection in a rat liver transplantation model by a liver-targeted dextran prodrug of methylprednisolone.
    Chimalakonda AP, Montgomery DL, Weidanz JA, Shaik IH, Nguyen JH, Lemasters JJ, Kobayashi E, Mehvar R.
    Transplantation; 2006 Mar 15; 81(5):678-85. PubMed ID: 16534468
    [Abstract] [Full Text] [Related]

  • 18. Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
    Kong H, Lee Y, Hong S, Han J, Choi B, Jung Y, Kim YM.
    J Drug Target; 2009 Jul 15; 17(6):450-8. PubMed ID: 19527116
    [Abstract] [Full Text] [Related]

  • 19. Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug.
    Zhang SQ, Thorsheim HR, Penugonda S, Pillai VC, Smith QR, Mehvar R.
    J Chromatogr B Analyt Technol Biomed Life Sci; 2009 Apr 01; 877(10):927-32. PubMed ID: 19269263
    [Abstract] [Full Text] [Related]

  • 20. Pharmacokinetic and pharmacodynamic assessment of bioavailability for two prodrugs of methylprednisolone.
    Daley-Yates PT, Gregory AJ, Brooks CD.
    Br J Clin Pharmacol; 1997 Jun 01; 43(6):593-601. PubMed ID: 9205819
    [Abstract] [Full Text] [Related]

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