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199 related items for PubMed ID: 10887097

  • 1. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.
    Kitada S, Zapata JM, Andreeff M, Reed JC.
    Blood; 2000 Jul 15; 96(2):393-7. PubMed ID: 10887097
    [Abstract] [Full Text] [Related]

  • 2. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.
    König A, Schwartz GK, Mohammad RM, Al-Katib A, Gabrilove JL.
    Blood; 1997 Dec 01; 90(11):4307-12. PubMed ID: 9373241
    [Abstract] [Full Text] [Related]

  • 3. Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
    Byrd JC, Shinn C, Waselenko JK, Fuchs EJ, Lehman TA, Nguyen PL, Flinn IW, Diehl LF, Sausville E, Grever MR.
    Blood; 1998 Nov 15; 92(10):3804-16. PubMed ID: 9808574
    [Abstract] [Full Text] [Related]

  • 4. Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
    Gao N, Dai Y, Rahmani M, Dent P, Grant S.
    Mol Pharmacol; 2004 Oct 15; 66(4):956-63. PubMed ID: 15235103
    [Abstract] [Full Text] [Related]

  • 5. The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
    Pei XY, Dai Y, Grant S.
    Mol Cancer Ther; 2004 Dec 15; 3(12):1513-24. PubMed ID: 15634644
    [Abstract] [Full Text] [Related]

  • 6. Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
    Rosato RR, Almenara JA, Kolla SS, Maggio SC, Coe S, Giménez MS, Dent P, Grant S.
    Mol Cancer Ther; 2007 Feb 15; 6(2):692-702. PubMed ID: 17308065
    [Abstract] [Full Text] [Related]

  • 7. Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
    Senderowicz AM.
    Leukemia; 2001 Jan 15; 15(1):1-9. PubMed ID: 11243375
    [Abstract] [Full Text] [Related]

  • 8. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.
    Gojo I, Zhang B, Fenton RG.
    Clin Cancer Res; 2002 Nov 15; 8(11):3527-38. PubMed ID: 12429644
    [Abstract] [Full Text] [Related]

  • 9. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.
    Chen R, Keating MJ, Gandhi V, Plunkett W.
    Blood; 2005 Oct 01; 106(7):2513-9. PubMed ID: 15972445
    [Abstract] [Full Text] [Related]

  • 10. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
    Dai Y, Yu C, Singh V, Tang L, Wang Z, McInistry R, Dent P, Grant S.
    Cancer Res; 2001 Jul 01; 61(13):5106-15. PubMed ID: 11431348
    [Abstract] [Full Text] [Related]

  • 11. A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines.
    Wu K, D'Amico M, Wang C, Albanese C, Pestell RG, Mani S.
    Invest New Drugs; 2005 Aug 01; 23(4):299-309. PubMed ID: 16012789
    [Abstract] [Full Text] [Related]

  • 12. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses.
    Kitada S, Andersen J, Akar S, Zapata JM, Takayama S, Krajewski S, Wang HG, Zhang X, Bullrich F, Croce CM, Rai K, Hines J, Reed JC.
    Blood; 1998 May 01; 91(9):3379-89. PubMed ID: 9558396
    [Abstract] [Full Text] [Related]

  • 13. Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
    Rosato RR, Dai Y, Almenara JA, Maggio SC, Grant S.
    Leukemia; 2004 Nov 01; 18(11):1780-8. PubMed ID: 15385934
    [Abstract] [Full Text] [Related]

  • 14. Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
    Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S.
    Mol Pharmacol; 1997 Dec 01; 52(6):1000-9. PubMed ID: 9396780
    [Abstract] [Full Text] [Related]

  • 15. Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells.
    Marzo I, Pérez-Galán P, Giraldo P, López-Royuela N, Gómez-Benito M, Larrad L, Lasierra P, Rubio-Félix D, Anel A, Naval J.
    Leukemia; 2004 Oct 01; 18(10):1599-604. PubMed ID: 15356656
    [Abstract] [Full Text] [Related]

  • 16. Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.
    Ma Y, Cress WD, Haura EB.
    Mol Cancer Ther; 2003 Jan 01; 2(1):73-81. PubMed ID: 12533675
    [Abstract] [Full Text] [Related]

  • 17. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
    Dai Y, Rahmani M, Grant S.
    Oncogene; 2003 Oct 16; 22(46):7108-22. PubMed ID: 14562039
    [Abstract] [Full Text] [Related]

  • 18. Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
    Lee YK, Isham CR, Kaufman SH, Bible KC.
    Mol Cancer Ther; 2006 Jan 16; 5(1):138-48. PubMed ID: 16432172
    [Abstract] [Full Text] [Related]

  • 19. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
    Shao RG, Shimizu T, Pommier Y.
    Exp Cell Res; 1997 Aug 01; 234(2):388-97. PubMed ID: 9260909
    [Abstract] [Full Text] [Related]

  • 20. The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract.
    Zaher M, Mirshahi M, Nuraliev Y, Sharofova M, Bombarda I, Marie JP, Billard C.
    Int J Oncol; 2011 Oct 01; 39(4):965-72. PubMed ID: 21750864
    [Abstract] [Full Text] [Related]

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