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Journal Abstract Search

243 related items for PubMed ID: 10901705

  • 1. Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation.
    Cuttle L, Munns AJ, Hogg NA, Scott JR, Hooper WD, Dickinson RG, Gillam EM.
    Drug Metab Dispos; 2000 Aug; 28(8):945-50. PubMed ID: 10901705
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  • 2. P450 2C18 catalyzes the metabolic bioactivation of phenytoin.
    Kinobe RT, Parkinson OT, Mitchell DJ, Gillam EM.
    Chem Res Toxicol; 2005 Dec; 18(12):1868-75. PubMed ID: 16359177
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  • 3. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ, De Voss JJ, Hooper WD, Dickinson RG, Gillam EM.
    Chem Res Toxicol; 1997 Sep; 10(9):1049-58. PubMed ID: 9305589
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  • 4. Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats.
    Yamazaki H, Komatsu T, Takemoto K, Saeki M, Minami Y, Kawaguchi Y, Shimada N, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2001 Apr; 29(4 Pt 1):427-34. PubMed ID: 11259327
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  • 5. Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4.
    Komatsu T, Yamazaki H, Asahi S, Gillam EM, Guengerich FP, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2000 Nov; 28(11):1361-8. PubMed ID: 11038165
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  • 6. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
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  • 7. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
    Avent KM, DeVoss JJ, Gillam EM.
    Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
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  • 8. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
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  • 11. Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives.
    Notley LM, Crewe KH, Taylor PJ, Lennard MS, Gillam EM.
    Chem Res Toxicol; 2005 Oct; 18(10):1611-8. PubMed ID: 16533026
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  • 17. Detection of cytochrome P4503A (CYP3A) in human hepatic stellate cells.
    Parola M, Robino G, Bordone R, Leonarduzzi G, Casini A, Pinzani M, Neve E, Bellomo G, Dianzani MU, Ingelman-Sundberg M, Albano E.
    Biochem Biophys Res Commun; 1997 Sep 18; 238(2):420-4. PubMed ID: 9299524
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  • 18. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes.
    Zhu M, Zhao W, Jimenez H, Zhang D, Yeola S, Dai R, Vachharajani N, Mitroka J.
    Drug Metab Dispos; 2005 Apr 18; 33(4):500-7. PubMed ID: 15640381
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  • 19. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
    Zhang D, Wang L, Chandrasena G, Ma L, Zhu M, Zhang H, Davis CD, Humphreys WG.
    Drug Metab Dispos; 2007 Jan 18; 35(1):139-49. PubMed ID: 17062778
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