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240 related items for PubMed ID: 10912950
1. 1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range as daunorubicin in vitro. Perchellet EM, Magill MJ, Huang X, Dalke DM, Hua DH, Perchellet JP. Anticancer Drugs; 2000 Jun; 11(5):339-52. PubMed ID: 10912950 [Abstract] [Full Text] [Related]
2. Triptycenes: a novel synthetic class of bifunctional anticancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro. Perchellet EM, Magill MJ, Huang X, Brantis CE, Hua DH, Perchellet JP. Anticancer Drugs; 1999 Sep; 10(8):749-66. PubMed ID: 10573208 [Abstract] [Full Text] [Related]
3. Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro. Perchellet EM, Sperfslage BJ, Qabaja G, Jones GB, Perchellet JP. Anticancer Drugs; 2001 Jun; 12(5):401-17. PubMed ID: 11395569 [Abstract] [Full Text] [Related]
4. Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro. Perchellet EM, Sperfslage BJ, Wang Y, Huang X, Tamura M, Hua DH, Perchellet JP. Anticancer Drugs; 2002 Jul; 13(6):567-81. PubMed ID: 12172502 [Abstract] [Full Text] [Related]
5. Synthetic 1,4-anthracenediones, which block nucleoside transport and induce DNA fragmentation, retain their cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines. Wu M, Wang B, Perchellet EM, Sperfslage BJ, Stephany HA, Hua DH, Perchellet JP. Anticancer Drugs; 2001 Nov; 12(10):807-19. PubMed ID: 11707648 [Abstract] [Full Text] [Related]
10. Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Wang Y, Perchellet EM, Tamura M, Hua DH, Perchellet JP. Cancer Lett; 2002 Dec 15; 188(1-2):73-83. PubMed ID: 12406551 [Abstract] [Full Text] [Related]
11. Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling. Perchellet EM, Wang Y, Weber RL, Lou K, Hua DH, Perchellet JP. Anticancer Drugs; 2004 Nov 15; 15(10):929-46. PubMed ID: 15514562 [Abstract] [Full Text] [Related]
13. Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. Perchellet EM, Wang Y, Weber RL, Sperfslage BJ, Lou K, Crossland J, Hua DH, Perchellet JP. Biochem Pharmacol; 2004 Feb 01; 67(3):523-37. PubMed ID: 15037204 [Abstract] [Full Text] [Related]
14. Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro. Perchellet JP, Waters AM, Perchellet EM, Thornton PD, Brown N, Hill D, Neuenswander B, Lushington GH, Santini C, Chandrasoma N, Buszek KR. Anticancer Res; 2012 Nov 01; 32(11):4671-84. PubMed ID: 23155229 [Abstract] [Full Text] [Related]
15. Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. Perchellet EM, Wang Y, Lou K, Zhao H, Battina SK, Hua DH, Perchellet JP. Int J Oncol; 2007 Nov 01; 31(5):1231-41. PubMed ID: 17912452 [Abstract] [Full Text] [Related]
16. Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro. Perchellet JP, Waters AM, Perchellet EM, Naganaboina VK, Chandra KL, Desper J, Rayat S. Anticancer Res; 2011 Jun 01; 31(6):2083-93. PubMed ID: 21737626 [Abstract] [Full Text] [Related]