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352 related items for PubMed ID: 10913131

  • 1. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.
    Lock LS, Royal I, Naujokas MA, Park M.
    J Biol Chem; 2000 Oct 06; 275(40):31536-45. PubMed ID: 10913131
    [Abstract] [Full Text] [Related]

  • 2. Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain.
    Lock LS, Frigault MM, Saucier C, Park M.
    J Biol Chem; 2003 Aug 08; 278(32):30083-90. PubMed ID: 12766170
    [Abstract] [Full Text] [Related]

  • 3. The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
    Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM.
    Oncogene; 2001 Mar 01; 20(9):1052-62. PubMed ID: 11314042
    [Abstract] [Full Text] [Related]

  • 4. Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.
    Lock LS, Maroun CR, Naujokas MA, Park M.
    Mol Biol Cell; 2002 Jun 01; 13(6):2132-46. PubMed ID: 12058075
    [Abstract] [Full Text] [Related]

  • 5. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
    Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.
    J Cell Biol; 2000 Jun 26; 149(7):1419-32. PubMed ID: 10871282
    [Abstract] [Full Text] [Related]

  • 6. Gab1 coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential.
    Bardelli A, Longati P, Gramaglia D, Stella MC, Comoglio PM.
    Oncogene; 1997 Dec 18; 15(25):3103-11. PubMed ID: 9444958
    [Abstract] [Full Text] [Related]

  • 7. The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair.
    Fan S, Ma YX, Gao M, Yuan RQ, Meng Q, Goldberg ID, Rosen EM.
    Mol Cell Biol; 2001 Aug 18; 21(15):4968-84. PubMed ID: 11438654
    [Abstract] [Full Text] [Related]

  • 8. ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
    Yu CF, Liu ZX, Cantley LG.
    J Biol Chem; 2002 May 31; 277(22):19382-8. PubMed ID: 11896055
    [Abstract] [Full Text] [Related]

  • 9. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase.
    Maroun CR, Holgado-Madruga M, Royal I, Naujokas MA, Fournier TM, Wong AJ, Park M.
    Mol Cell Biol; 1999 Mar 31; 19(3):1784-99. PubMed ID: 10022866
    [Abstract] [Full Text] [Related]

  • 10. Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites.
    Fan YX, Wong L, Deb TB, Johnson GR.
    J Biol Chem; 2004 Sep 10; 279(37):38143-50. PubMed ID: 15231819
    [Abstract] [Full Text] [Related]

  • 11. Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.
    Maroun CR, Naujokas MA, Park M.
    Mol Biol Cell; 2003 Apr 10; 14(4):1691-708. PubMed ID: 12686619
    [Abstract] [Full Text] [Related]

  • 12. The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.
    Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H.
    J Biol Chem; 1995 Jun 23; 270(25):15341-7. PubMed ID: 7797522
    [Abstract] [Full Text] [Related]

  • 13. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
    Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J, Birchmeier W.
    Nature; 1996 Nov 14; 384(6605):173-6. PubMed ID: 8906793
    [Abstract] [Full Text] [Related]

  • 14. A conserved inositol phospholipid binding site within the pleckstrin homology domain of the Gab1 docking protein is required for epithelial morphogenesis.
    Maroun CR, Moscatello DK, Naujokas MA, Holgado-Madruga M, Wong AJ, Park M.
    J Biol Chem; 1999 Oct 29; 274(44):31719-26. PubMed ID: 10531383
    [Abstract] [Full Text] [Related]

  • 15. Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor.
    Frigault MM, Naujokas MA, Park M.
    J Cell Physiol; 2008 Mar 29; 214(3):694-705. PubMed ID: 17894413
    [Abstract] [Full Text] [Related]

  • 16. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.
    Berry DM, Nash P, Liu SK, Pawson T, McGlade CJ.
    Curr Biol; 2002 Aug 06; 12(15):1336-41. PubMed ID: 12176364
    [Abstract] [Full Text] [Related]

  • 17. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356.
    Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M.
    J Biol Chem; 1997 Aug 15; 272(33):20811-9. PubMed ID: 9252406
    [Abstract] [Full Text] [Related]

  • 18. ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
    Ong SH, Dilworth S, Hauck-Schmalenberger I, Pawson T, Kiefer F.
    EMBO J; 2001 Nov 15; 20(22):6327-36. PubMed ID: 11707404
    [Abstract] [Full Text] [Related]

  • 19. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1.
    Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M.
    J Biol Chem; 1997 Aug 08; 272(32):20167-72. PubMed ID: 9242692
    [Abstract] [Full Text] [Related]

  • 20. Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.
    Chaudhuri A, Xie MH, Yang B, Mahapatra K, Liu J, Marsters S, Bodepudi S, Ashkenazi A.
    J Biol Chem; 2011 Sep 16; 286(37):32762-74. PubMed ID: 21784853
    [Abstract] [Full Text] [Related]

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