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265 related items for PubMed ID: 10933062

  • 1. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.
    Dorie MJ, Kovacs MS, Gabalski EC, Adam M, Le QT, Bloch DA, Pinto HA, Terris DJ, Brown JM.
    Neoplasia; 1999 Nov; 1(5):461-7. PubMed ID: 10933062
    [Abstract] [Full Text] [Related]

  • 2. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
    Siim BG, Menke DR, Dorie MJ, Brown JM.
    Cancer Res; 1997 Jul 15; 57(14):2922-8. PubMed ID: 9230202
    [Abstract] [Full Text] [Related]

  • 3. Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status.
    Masunaga S, Ono K, Takahashi A, Ohnishi K, Ohnishi T, Suzuki M, Nagata K, Kinashi Y, Nagasawa H, Uto Y, Hori H.
    Cancer Sci; 2003 Jan 15; 94(1):125-33. PubMed ID: 12708486
    [Abstract] [Full Text] [Related]

  • 4. Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer.
    Wouters BG, Wang LH, Brown JM.
    Ann Oncol; 1999 Jan 15; 10 Suppl 5():S29-33. PubMed ID: 10582136
    [Abstract] [Full Text] [Related]

  • 5. Metabolism of tirapazamine by multiple reductases in the nucleus.
    Delahoussaye YM, Evans JW, Brown JM.
    Biochem Pharmacol; 2001 Nov 01; 62(9):1201-9. PubMed ID: 11705453
    [Abstract] [Full Text] [Related]

  • 6. Combined effects of tirapazamine and mild hyperthermia on anti-angiogenic agent (TNP-470) treated tumors-reference to the effect on intratumor quiescent cells.
    Masunaga S, Ono K, Nishimura Y, Kanamori S, Saga T, Suzuki M, Kinashi Y, Takagaki M, Kasai S, Nagasawa H, Uto Y, Hori H.
    Int J Radiat Oncol Biol Phys; 2000 Jun 01; 47(3):799-807. PubMed ID: 10837967
    [Abstract] [Full Text] [Related]

  • 7. Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting.
    Delahoussaye YM, Hay MP, Pruijn FB, Denny WA, Brown JM.
    Biochem Pharmacol; 2003 Jun 01; 65(11):1807-15. PubMed ID: 12781332
    [Abstract] [Full Text] [Related]

  • 8. Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts.
    Bhattacharya A, Tóth K, Durrani FA, Cao S, Slocum HK, Chintala S, Rustum YM.
    Neoplasia; 2008 Aug 01; 10(8):857-65. PubMed ID: 18670644
    [Abstract] [Full Text] [Related]

  • 9. Hypoxic sensitizer and cytotoxin for head and neck cancer.
    Lee DJ, Moini M, Giuliano J, Westra WH.
    Ann Acad Med Singap; 1996 May 01; 25(3):397-404. PubMed ID: 8876907
    [Abstract] [Full Text] [Related]

  • 10. Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumors in mice.
    Olive PL, Vikse CM, Banath JP.
    Cancer Res; 1996 Oct 01; 56(19):4460-3. PubMed ID: 8813141
    [Abstract] [Full Text] [Related]

  • 11. Changes in the sensitivity of intratumor cells during fractionated tirapazamine administration.
    Masunaga S, Ono K, Suzuki M, Kinashi Y, Takagaki M, Kasai S, Nagasawa H, Uto Y, Hori H.
    Jpn J Cancer Res; 2000 Jul 01; 91(7):731-6. PubMed ID: 10920281
    [Abstract] [Full Text] [Related]

  • 12. Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin.
    Kovacs MS, Hocking DJ, Evans JW, Siim BG, Wouters BG, Brown JM.
    Br J Cancer; 1999 Jun 01; 80(8):1245-51. PubMed ID: 10376978
    [Abstract] [Full Text] [Related]

  • 13. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT, Greenberg MM, Fuchs T, Gates KS.
    Biochemistry; 1999 Oct 26; 38(43):14248-55. PubMed ID: 10571998
    [Abstract] [Full Text] [Related]

  • 14. Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells.
    Moriwaki T, Okamoto S, Sasanuma H, Nagasawa H, Takeda S, Masunaga SI, Tano K.
    Chem Res Toxicol; 2017 Feb 20; 30(2):699-704. PubMed ID: 27943678
    [Abstract] [Full Text] [Related]

  • 15. Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage.
    Broekgaarden M, Weijer R, van Wijk AC, Cox RC, Egmond MR, Hoebe R, van Gulik TM, Heger M.
    J Biomed Nanotechnol; 2017 Feb 20; 13(2):204-20. PubMed ID: 29377650
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of DNA replication by tirapazamine.
    Peters KB, Wang H, Brown JM, Iliakis G.
    Cancer Res; 2001 Jul 15; 61(14):5425-31. PubMed ID: 11454687
    [Abstract] [Full Text] [Related]

  • 17. Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine.
    Dorie MJ, Brown JM.
    Cancer Chemother Pharmacol; 1997 Jul 15; 39(4):361-6. PubMed ID: 9025778
    [Abstract] [Full Text] [Related]

  • 18. Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes.
    Evans JW, Yudoh K, Delahoussaye YM, Brown JM.
    Cancer Res; 1998 May 15; 58(10):2098-101. PubMed ID: 9605751
    [Abstract] [Full Text] [Related]

  • 19. [Evaluation of the toxicity of tirapazamine plus cisplatin in a mouse tumor model].
    Adam M, Ottenjann S, Künzel G, Busch R, Erhardt W, Nieder C, Molls M.
    Strahlenther Onkol; 2006 Apr 15; 182(4):231-9. PubMed ID: 16622625
    [Abstract] [Full Text] [Related]

  • 20. Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors.
    Hicks KO, Siim BG, Pruijn FB, Wilson WR.
    Radiat Res; 2004 Jun 15; 161(6):656-66. PubMed ID: 15161354
    [Abstract] [Full Text] [Related]

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