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132 related items for PubMed ID: 10933201

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  • 3. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S, Xu-Welliver M, Bailey J, D'Souza M, Cooper R, Chandra S, Seshadri R, Pegg AE, Williams DA.
    Cancer Res; 2000 Sep 15; 60(18):5187-95. PubMed ID: 11016647
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  • 4. Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Davis BM, Reese JS, Koç ON, Lee K, Schupp JE, Gerson SL.
    Cancer Res; 1997 Nov 15; 57(22):5093-9. PubMed ID: 9371508
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  • 5. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy.
    Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL.
    Hum Gene Ther; 1999 Nov 20; 10(17):2769-78. PubMed ID: 10584923
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  • 6. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.
    Loktionova NA, Xu-Welliver M, Crone TM, Kanugula S, Pegg AE.
    Biochem Pharmacol; 1999 Jul 15; 58(2):237-44. PubMed ID: 10423163
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  • 7. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide.
    Reese JS, Davis BM, Liu L, Gerson SL.
    Clin Cancer Res; 1999 Jan 15; 5(1):163-9. PubMed ID: 9918215
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  • 8. G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU.
    Lee K, Gerson SL, Maitra B, Koç ON.
    J Hematother Stem Cell Res; 2001 Oct 15; 10(5):691-701. PubMed ID: 11672516
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  • 9. Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer.
    Koç ON, Reese JS, Szekely EM, Gerson SL.
    Cancer Gene Ther; 1999 Oct 15; 6(4):340-8. PubMed ID: 10419052
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  • 10. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells.
    Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL.
    Mol Cancer Ther; 2006 Jan 15; 5(1):121-8. PubMed ID: 16432170
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  • 11. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    Koç ON, Reese JS, Davis BM, Liu L, Majczenko KJ, Gerson SL.
    Hum Gene Ther; 1999 Apr 10; 10(6):1021-30. PubMed ID: 10223735
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  • 12. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Phillips WP, Willson JK, Markowitz SD, Zborowska E, Zaidi NH, Liu L, Gordon NH, Gerson SL.
    Cancer Res; 1997 Nov 01; 57(21):4817-23. PubMed ID: 9354444
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  • 13. Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients.
    Davis BM, Reese JS, Lingas K, Gerson SL.
    J Hematother Stem Cell Res; 2003 Aug 01; 12(4):375-87. PubMed ID: 12965075
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  • 14. Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Kreklau EL, Pollok KE, Bailey BJ, Liu N, Hartwell JR, Williams DA, Erickson LC.
    Mol Cancer Ther; 2003 Dec 01; 2(12):1321-9. PubMed ID: 14707273
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  • 15. Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide.
    Chinnasamy D, Fairbairn LJ, Neuenfeldt J, Treisman JS, Hanson JP, Margison GP, Chinnasamy N.
    Hum Gene Ther; 2004 Aug 01; 15(8):758-69. PubMed ID: 15319033
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  • 16. Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK, Dolan ME, Erickson LC.
    Cancer Res; 1994 Aug 15; 54(16):4371-5. PubMed ID: 8044784
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  • 17. Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
    Chen JM, Zhang YP, Moschel RC, Ikenaga M.
    Carcinogenesis; 1993 May 15; 14(5):1057-60. PubMed ID: 8504466
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  • 18. Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow.
    Kramer BA, Lemckert FA, Alexander IE, Gunning PW, McCowage GB.
    J Gene Med; 2006 Sep 15; 8(9):1071-85. PubMed ID: 16927363
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  • 19. In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning.
    Zielske SP, Reese JS, Lingas KT, Donze JR, Gerson SL.
    J Clin Invest; 2003 Nov 15; 112(10):1561-70. PubMed ID: 14617757
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  • 20. [Mutation of human O6-alkylguanine-DNA alkyltransferase confers resistance to O6-benzylguanine].
    Wan Y, Wu D, Gao H.
    Zhonghua Zhong Liu Za Zhi; 2000 Jul 15; 22(4):290-3. PubMed ID: 11778552
    [Abstract] [Full Text] [Related]

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