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1397 related items for PubMed ID: 10944113

  • 1. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
    Tanimoto K, Makino Y, Pereira T, Poellinger L.
    EMBO J; 2000 Aug 15; 19(16):4298-309. PubMed ID: 10944113
    [Abstract] [Full Text] [Related]

  • 2. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
    Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.
    J Biol Chem; 2000 Aug 18; 275(33):25733-41. PubMed ID: 10823831
    [Abstract] [Full Text] [Related]

  • 3. Dynamic, site-specific interaction of hypoxia-inducible factor-1alpha with the von Hippel-Lindau tumor suppressor protein.
    Yu F, White SB, Zhao Q, Lee FS.
    Cancer Res; 2001 May 15; 61(10):4136-42. PubMed ID: 11358837
    [Abstract] [Full Text] [Related]

  • 4. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
    Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.
    Nature; 1999 May 20; 399(6733):271-5. PubMed ID: 10353251
    [Abstract] [Full Text] [Related]

  • 5. Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function.
    Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH.
    Oncogene; 2000 Nov 16; 19(48):5435-43. PubMed ID: 11114720
    [Abstract] [Full Text] [Related]

  • 6. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
    Mahon PC, Hirota K, Semenza GL.
    Genes Dev; 2001 Oct 15; 15(20):2675-86. PubMed ID: 11641274
    [Abstract] [Full Text] [Related]

  • 7. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.
    IUBMB Life; 2001 Jul 15; 52(1-2):43-7. PubMed ID: 11795592
    [Abstract] [Full Text] [Related]

  • 8. Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor gene product.
    Pereira T, Zheng X, Ruas JL, Tanimoto K, Poellinger L.
    J Biol Chem; 2003 Feb 28; 278(9):6816-23. PubMed ID: 12468553
    [Abstract] [Full Text] [Related]

  • 9. HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation.
    Yu F, White SB, Zhao Q, Lee FS.
    Proc Natl Acad Sci U S A; 2001 Aug 14; 98(17):9630-5. PubMed ID: 11504942
    [Abstract] [Full Text] [Related]

  • 10. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
    Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ.
    EMBO J; 2001 Sep 17; 20(18):5197-206. PubMed ID: 11566883
    [Abstract] [Full Text] [Related]

  • 11. VHL takes HIF's breath away.
    Krek W.
    Nat Cell Biol; 2000 Jul 17; 2(7):E121-3. PubMed ID: 10878820
    [Abstract] [Full Text] [Related]

  • 12. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.
    Science; 2001 Apr 20; 292(5516):468-72. PubMed ID: 11292861
    [Abstract] [Full Text] [Related]

  • 13. Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway.
    Blancher C, Moore JW, Robertson N, Harris AL.
    Cancer Res; 2001 Oct 01; 61(19):7349-55. PubMed ID: 11585776
    [Abstract] [Full Text] [Related]

  • 14. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
    Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG.
    Nat Cell Biol; 2000 Jul 01; 2(7):423-7. PubMed ID: 10878807
    [Abstract] [Full Text] [Related]

  • 15. Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.
    Sang N, Fang J, Srinivas V, Leshchinsky I, Caro J.
    Mol Cell Biol; 2002 May 01; 22(9):2984-92. PubMed ID: 11940656
    [Abstract] [Full Text] [Related]

  • 16. HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation.
    Berra E, Richard DE, Gothié E, Pouysségur J.
    FEBS Lett; 2001 Feb 23; 491(1-2):85-90. PubMed ID: 11226425
    [Abstract] [Full Text] [Related]

  • 17. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas.
    Wiesener MS, Münchenhagen PM, Berger I, Morgan NV, Roigas J, Schwiertz A, Jürgensen JS, Gruber G, Maxwell PH, Löning SA, Frei U, Maher ER, Gröne HJ, Eckardt KU.
    Cancer Res; 2001 Jul 01; 61(13):5215-22. PubMed ID: 11431362
    [Abstract] [Full Text] [Related]

  • 18. Molecular cloning and characterization of the von Hippel-Lindau-like protein.
    Qi H, Gervais ML, Li W, DeCaprio JA, Challis JR, Ohh M.
    Mol Cancer Res; 2004 Jan 01; 2(1):43-52. PubMed ID: 14757845
    [Abstract] [Full Text] [Related]

  • 19. The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism.
    Tang TT, Lasky LA.
    J Biol Chem; 2003 Aug 08; 278(32):30125-35. PubMed ID: 12761217
    [Abstract] [Full Text] [Related]

  • 20. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
    Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG.
    Hum Mol Genet; 2001 May 01; 10(10):1019-27. PubMed ID: 11331612
    [Abstract] [Full Text] [Related]

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