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336 related items for PubMed ID: 10958682

  • 1. 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
    Taylor V, Wong M, Brandts C, Reilly L, Dean NM, Cowsert LM, Moodie S, Stokoe D.
    Mol Cell Biol; 2000 Sep; 20(18):6860-71. PubMed ID: 10958682
    [Abstract] [Full Text] [Related]

  • 2. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
    Freeburn RW, Wright KL, Burgess SJ, Astoul E, Cantrell DA, Ward SG.
    J Immunol; 2002 Nov 15; 169(10):5441-50. PubMed ID: 12421919
    [Abstract] [Full Text] [Related]

  • 3. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
    Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D.
    Curr Biol; 1998 Oct 22; 8(21):1195-8. PubMed ID: 9799739
    [Abstract] [Full Text] [Related]

  • 4. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
    Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.
    Oncogene; 2002 Aug 08; 21(34):5289-300. PubMed ID: 12149650
    [Abstract] [Full Text] [Related]

  • 5. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
    Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jücker M.
    Leukemia; 2004 Nov 08; 18(11):1839-49. PubMed ID: 15457186
    [Abstract] [Full Text] [Related]

  • 6. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice.
    Scheid MP, Huber M, Damen JE, Hughes M, Kang V, Neilsen P, Prestwich GD, Krystal G, Duronio V.
    J Biol Chem; 2002 Mar 15; 277(11):9027-35. PubMed ID: 11781306
    [Abstract] [Full Text] [Related]

  • 7. PTEN expression causes feedback upregulation of insulin receptor substrate 2.
    Simpson L, Li J, Liaw D, Hennessy I, Oliner J, Christians F, Parsons R.
    Mol Cell Biol; 2001 Jun 15; 21(12):3947-58. PubMed ID: 11359902
    [Abstract] [Full Text] [Related]

  • 8. SHIP-2 and PTEN are expressed and active in vascular smooth muscle cell nuclei, but only SHIP-2 is associated with nuclear speckles.
    Déléris P, Bacqueville D, Gayral S, Carrez L, Salles JP, Perret B, Breton-Douillon M.
    J Biol Chem; 2003 Oct 03; 278(40):38884-91. PubMed ID: 12847108
    [Abstract] [Full Text] [Related]

  • 9. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.
    Li DM, Sun H.
    Proc Natl Acad Sci U S A; 1998 Dec 22; 95(26):15406-11. PubMed ID: 9860981
    [Abstract] [Full Text] [Related]

  • 10. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
    Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T.
    Mol Endocrinol; 2001 Aug 22; 15(8):1411-22. PubMed ID: 11463863
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
    Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S.
    Oncogene; 2005 May 19; 24(22):3596-605. PubMed ID: 15782140
    [Abstract] [Full Text] [Related]

  • 12. PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.
    Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM.
    Mol Cell Biol; 2003 Sep 19; 23(17):6139-49. PubMed ID: 12917336
    [Abstract] [Full Text] [Related]

  • 13. Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.
    Ermoian RP, Furniss CS, Lamborn KR, Basila D, Berger MS, Gottschalk AR, Nicholas MK, Stokoe D, Haas-Kogan DA.
    Clin Cancer Res; 2002 May 19; 8(5):1100-6. PubMed ID: 12006525
    [Abstract] [Full Text] [Related]

  • 14. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.
    Sharrard RM, Maitland NJ.
    Cell Signal; 2007 Jan 19; 19(1):129-38. PubMed ID: 16842970
    [Abstract] [Full Text] [Related]

  • 15. Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
    Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP.
    Biochem J; 2001 Jul 15; 357(Pt 2):427-35. PubMed ID: 11439092
    [Abstract] [Full Text] [Related]

  • 16. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
    Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H.
    Proc Natl Acad Sci U S A; 1999 May 25; 96(11):6199-204. PubMed ID: 10339565
    [Abstract] [Full Text] [Related]

  • 17. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.
    Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.
    Mol Cell Biol; 2000 Sep 25; 20(18):6945-57. PubMed ID: 10958690
    [Abstract] [Full Text] [Related]

  • 18. PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer.
    Csolle MP, Ooms LM, Papa A, Mitchell CA.
    Int J Mol Sci; 2020 Dec 02; 21(23):. PubMed ID: 33276499
    [Abstract] [Full Text] [Related]

  • 19. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.
    Ma K, Cheung SM, Marshall AJ, Duronio V.
    Cell Signal; 2008 Apr 02; 20(4):684-94. PubMed ID: 18249092
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.
    Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S.
    Proc Natl Acad Sci U S A; 2000 Mar 28; 97(7):3207-12. PubMed ID: 10716737
    [Abstract] [Full Text] [Related]

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