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336 related items for PubMed ID: 10962005

  • 1. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
    Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE.
    J Biol Chem; 2000 Nov 24; 275(47):36794-802. PubMed ID: 10962005
    [Abstract] [Full Text] [Related]

  • 2. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999 Nov 24; 249(6):266-70. PubMed ID: 10653281
    [Abstract] [Full Text] [Related]

  • 3. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 4. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface.
    Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G.
    Neurobiol Dis; 2002 Oct 24; 11(1):64-82. PubMed ID: 12460547
    [Abstract] [Full Text] [Related]

  • 5. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
    Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ.
    Proc Natl Acad Sci U S A; 2000 Aug 01; 97(16):9299-304. PubMed ID: 10922078
    [Abstract] [Full Text] [Related]

  • 6. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 01; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 7. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.
    Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B.
    J Cell Biol; 1999 Oct 18; 147(2):277-94. PubMed ID: 10525535
    [Abstract] [Full Text] [Related]

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  • 9. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 10. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
    Xia W.
    Exp Gerontol; 2000 Jul 05; 35(4):453-60. PubMed ID: 10959033
    [Abstract] [Full Text] [Related]

  • 11. Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
    Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H.
    J Biol Chem; 2009 May 01; 284(18):12145-52. PubMed ID: 19276086
    [Abstract] [Full Text] [Related]

  • 12. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D, Kienlen-Campard P, Octave JN.
    J Neurochem; 2002 Oct 01; 83(2):390-9. PubMed ID: 12423249
    [Abstract] [Full Text] [Related]

  • 13. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.
    Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.
    J Cell Biol; 2001 Aug 20; 154(4):731-40. PubMed ID: 11502763
    [Abstract] [Full Text] [Related]

  • 14. Intracellular site of gamma-secretase cleavage for Abeta42 generation in neuro 2a cells harbouring a presenilin 1 mutation.
    Sudoh S, Hua G, Kawamura Y, Maruyama K, Komano H, Yanagisawa K.
    Eur J Biochem; 2000 Apr 20; 267(7):2036-45. PubMed ID: 10727943
    [Abstract] [Full Text] [Related]

  • 15. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H.
    J Biol Chem; 2005 Apr 29; 280(17):17020-6. PubMed ID: 15711015
    [Abstract] [Full Text] [Related]

  • 16. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M.
    J Biol Chem; 2004 Dec 03; 279(49):51654-60. PubMed ID: 15456764
    [Abstract] [Full Text] [Related]

  • 17. Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.
    Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.
    J Neurosci; 2002 May 01; 22(9):3445-53. PubMed ID: 11978821
    [Abstract] [Full Text] [Related]

  • 18. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
    Pitsi D, Octave JN.
    J Biol Chem; 2004 Jun 11; 279(24):25333-8. PubMed ID: 15087467
    [Abstract] [Full Text] [Related]

  • 19. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.
    Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P.
    J Biol Chem; 2001 Nov 16; 276(46):42645-57. PubMed ID: 11526104
    [Abstract] [Full Text] [Related]

  • 20. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
    Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, Ziani-Cherif C, Onstead L, Sambamurti K.
    J Biol Chem; 2001 Jan 05; 276(1):481-7. PubMed ID: 11035007
    [Abstract] [Full Text] [Related]

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