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549 related items for PubMed ID: 10973490

  • 1. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
    Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.
    Proc Natl Acad Sci U S A; 2000 Sep 12; 97(19):10389-94. PubMed ID: 10973490
    [Abstract] [Full Text] [Related]

  • 2. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.
    Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE.
    Cancer Res; 2000 Nov 01; 60(21):5934-6. PubMed ID: 11085506
    [Abstract] [Full Text] [Related]

  • 3. Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
    Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.
    Mutat Res; 2006 Apr 11; 596(1-2):166-76. PubMed ID: 16481012
    [Abstract] [Full Text] [Related]

  • 4. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway.
    Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR, Zhang X, Annan RS, Lu Q, Faucette LF, Scott GF, Li X, Carr SA, Johnson RK, Winkler JD, Zhou BB.
    Oncogene; 1999 Jul 15; 18(28):4047-54. PubMed ID: 10435585
    [Abstract] [Full Text] [Related]

  • 5. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
    Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TW.
    Mol Cell Biol; 2002 Sep 15; 22(18):6521-32. PubMed ID: 12192050
    [Abstract] [Full Text] [Related]

  • 6. Chk2 activation and phosphorylation-dependent oligomerization.
    Xu X, Tsvetkov LM, Stern DF.
    Mol Cell Biol; 2002 Jun 15; 22(12):4419-32. PubMed ID: 12024051
    [Abstract] [Full Text] [Related]

  • 7. Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.
    Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA.
    J Biol Chem; 2005 Jan 14; 280(2):1186-92. PubMed ID: 15533933
    [Abstract] [Full Text] [Related]

  • 8. Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.
    Tanaka K, Boddy MN, Chen XB, McGowan CH, Russell P.
    Mol Cell Biol; 2001 May 14; 21(10):3398-404. PubMed ID: 11313465
    [Abstract] [Full Text] [Related]

  • 9. Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.
    Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.
    J Biol Chem; 2000 Apr 07; 275(14):10342-8. PubMed ID: 10744722
    [Abstract] [Full Text] [Related]

  • 10. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
    Gatei M, Sloper K, Sorensen C, Syljuäsen R, Falck J, Hobson K, Savage K, Lukas J, Zhou BB, Bartek J, Khanna KK.
    J Biol Chem; 2003 Apr 25; 278(17):14806-11. PubMed ID: 12588868
    [Abstract] [Full Text] [Related]

  • 11. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
    Falck J, Mailand N, Syljuåsen RG, Bartek J, Lukas J.
    Nature; 2001 Apr 12; 410(6830):842-7. PubMed ID: 11298456
    [Abstract] [Full Text] [Related]

  • 12. Biochemical and cellular characterization of VRX0466617, a novel and selective inhibitor for the checkpoint kinase Chk2.
    Carlessi L, Buscemi G, Larson G, Hong Z, Wu JZ, Delia D.
    Mol Cancer Ther; 2007 Mar 12; 6(3):935-44. PubMed ID: 17363488
    [Abstract] [Full Text] [Related]

  • 13. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.
    Melchionna R, Chen XB, Blasina A, McGowan CH.
    Nat Cell Biol; 2000 Oct 12; 2(10):762-5. PubMed ID: 11025670
    [Abstract] [Full Text] [Related]

  • 14. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
    Gibson SL, Bindra RS, Glazer PM.
    Cancer Res; 2005 Dec 01; 65(23):10734-41. PubMed ID: 16322218
    [Abstract] [Full Text] [Related]

  • 15. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
    Matsuoka S, Huang M, Elledge SJ.
    Science; 1998 Dec 04; 282(5395):1893-7. PubMed ID: 9836640
    [Abstract] [Full Text] [Related]

  • 16. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies.
    Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK.
    J Biol Chem; 2001 May 18; 276(20):17276-80. PubMed ID: 11278964
    [Abstract] [Full Text] [Related]

  • 17. Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway.
    Araya R, Hirai I, Meyerkord CL, Wang HG.
    FEBS Lett; 2005 Jan 03; 579(1):157-61. PubMed ID: 15620706
    [Abstract] [Full Text] [Related]

  • 18. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
    Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR.
    Biochem J; 2002 Dec 01; 368(Pt 2):507-16. PubMed ID: 12234250
    [Abstract] [Full Text] [Related]

  • 19. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase.
    Chan DW, Son SC, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP.
    J Biol Chem; 2000 Mar 17; 275(11):7803-10. PubMed ID: 10713094
    [Abstract] [Full Text] [Related]

  • 20. ATR dependent activation of Chk2.
    Wang XQ, Redpath JL, Fan ST, Stanbridge EJ.
    J Cell Physiol; 2006 Sep 17; 208(3):613-9. PubMed ID: 16741947
    [Abstract] [Full Text] [Related]

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