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208 related items for PubMed ID: 10985775

  • 1. Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis.
    Wall M, Shim JH, Benkovic SJ.
    Biochemistry; 2000 Sep 19; 39(37):11303-11. PubMed ID: 10985775
    [Abstract] [Full Text] [Related]

  • 2. Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.
    Wolan DW, Cheong CG, Greasley SE, Wilson IA.
    Biochemistry; 2004 Feb 10; 43(5):1171-83. PubMed ID: 14756553
    [Abstract] [Full Text] [Related]

  • 3. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography.
    Szabados E, Christopherson RI.
    Anal Biochem; 1994 Sep 10; 221(2):401-4. PubMed ID: 7810885
    [Abstract] [Full Text] [Related]

  • 4. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus.
    Lonare S, Rode S, Verma P, Verma S, Kaur H, Alam MS, Wangmo P, Kumar P, Roy P, Sharma AK.
    Biochim Biophys Acta Proteins Proteom; 2024 Jul 01; 1872(4):141015. PubMed ID: 38615986
    [Abstract] [Full Text] [Related]

  • 5. Relationship between the catalytic sites of human bifunctional IMP synthase.
    Szabados E, Christopherson RI.
    Int J Biochem Cell Biol; 1998 Aug 01; 30(8):933-42. PubMed ID: 9744084
    [Abstract] [Full Text] [Related]

  • 6. Structural insights into the avian AICAR transformylase mechanism.
    Wolan DW, Greasley SE, Beardsley GP, Wilson IA.
    Biochemistry; 2002 Dec 31; 41(52):15505-13. PubMed ID: 12501179
    [Abstract] [Full Text] [Related]

  • 7. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis.
    Verma P, Kar B, Varshney R, Roy P, Sharma AK.
    FEBS J; 2017 Dec 31; 284(24):4233-4261. PubMed ID: 29063699
    [Abstract] [Full Text] [Related]

  • 8. 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors.
    Szabados E, Hindmarsh EJ, Phillips L, Duggleby RG, Christopherson RI.
    Biochemistry; 1994 Nov 29; 33(47):14237-45. PubMed ID: 7947835
    [Abstract] [Full Text] [Related]

  • 9. Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
    Cheong CG, Wolan DW, Greasley SE, Horton PA, Beardsley GP, Wilson IA.
    J Biol Chem; 2004 Apr 23; 279(17):18034-45. PubMed ID: 14966129
    [Abstract] [Full Text] [Related]

  • 10. Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
    Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA.
    Biochemistry; 2003 Sep 23; 42(37):10904-14. PubMed ID: 12974624
    [Abstract] [Full Text] [Related]

  • 11. Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization.
    Capps KJ, Humiston J, Dominique R, Hwang I, Boger DL.
    Bioorg Med Chem Lett; 2005 Jun 02; 15(11):2840-4. PubMed ID: 15911265
    [Abstract] [Full Text] [Related]

  • 12. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
    Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2002 Aug 02; 10(8):2739-49. PubMed ID: 12057663
    [Abstract] [Full Text] [Related]

  • 13. Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations.
    Shim JH, Wall M, Benkovic SJ, Díaz N, Suárez D, Merz KM.
    J Am Chem Soc; 2001 May 23; 123(20):4687-96. PubMed ID: 11457277
    [Abstract] [Full Text] [Related]

  • 14. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase.
    Vergis JM, Beardsley GP.
    Biochemistry; 2004 Feb 10; 43(5):1184-92. PubMed ID: 14756554
    [Abstract] [Full Text] [Related]

  • 15. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors.
    Li C, Xu L, Wolan DW, Wilson IA, Olson AJ.
    J Med Chem; 2004 Dec 30; 47(27):6681-90. PubMed ID: 15615517
    [Abstract] [Full Text] [Related]

  • 16. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4503-9. PubMed ID: 13129586
    [Abstract] [Full Text] [Related]

  • 17. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling.
    Bulock KG, Beardsley GP, Anderson KS.
    J Biol Chem; 2002 Jun 21; 277(25):22168-74. PubMed ID: 11948179
    [Abstract] [Full Text] [Related]

  • 18. Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity.
    Vergis JM, Bulock KG, Fleming KG, Beardsley GP.
    J Biol Chem; 2001 Mar 16; 276(11):7727-33. PubMed ID: 11096114
    [Abstract] [Full Text] [Related]

  • 19. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
    Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL.
    Bioorg Med Chem; 2003 Oct 01; 11(20):4487-501. PubMed ID: 13129585
    [Abstract] [Full Text] [Related]

  • 20. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
    Xu L, Li C, Olson AJ, Wilson IA.
    J Biol Chem; 2004 Nov 26; 279(48):50555-65. PubMed ID: 15355974
    [Abstract] [Full Text] [Related]

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