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89 related items for PubMed ID: 10987367
1. New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position. Steinmetzer T, Batdordshjin M, Pineda F, Seyfarth L, Vogel A, Reissmann S, Hauptmann J, Stürzebecher J. Biol Chem; 2000 Jul; 381(7):603-10. PubMed ID: 10987367 [Abstract] [Full Text] [Related]
2. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures. Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y. Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407 [Abstract] [Full Text] [Related]
7. Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors. Su Z, Vinogradova A, Koutychenko A, Tolkatchev D, Ni F. Protein Eng Des Sel; 2004 Aug 07; 17(8):647-57. PubMed ID: 15358856 [Abstract] [Full Text] [Related]
8. Potent bivalent thrombin inhibitors: replacement of the scissile peptide bond at P(1)-P(1)' with arginyl ketomethylene isosteres. Steinmetzer T, Zhu BY, Konishi Y. J Med Chem; 1999 Aug 12; 42(16):3109-15. PubMed ID: 10447955 [Abstract] [Full Text] [Related]
9. Structure-activity relationships of new NAPAP-analogs. Steinmetzer T, Schweinitz A, Künzel S, Wikström P, Hauptmann J, Stürzebecher J. J Enzyme Inhib Med Chem; 2002 Apr 12; 17(2):241-9. PubMed ID: 12420761 [Abstract] [Full Text] [Related]
10. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex. De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V. Protein Sci; 1998 Feb 12; 7(2):243-53. PubMed ID: 9521099 [Abstract] [Full Text] [Related]
17. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors. Lombardi A, Nastri F, Della Morte R, Rossi A, De Rosa A, Staiano N, Pedone C, Pavone V. J Med Chem; 1996 May 10; 39(10):2008-17. PubMed ID: 8642559 [Abstract] [Full Text] [Related]
18. Active site-directed thrombin inhibitors: alpha-hydroxyacyl-prolyl-arginals, new orally active stable analogues of D-Phe-Pro-Arg-H. Bajusz S, Barabas E, Fauszt I, Feher A, Horvath G, Juhasz A, Szabo GA, Szell E. Semin Thromb Hemost; 1996 May 10; 22(3):243-6. PubMed ID: 8836008 [Abstract] [Full Text] [Related]
19. Incorporation of noncoded amino acids into the N-terminal domain 1-47 of hirudin yields a highly potent and selective thrombin inhibitor. De Filippis V, Russo I, Vindigni A, Di Cera E, Salmaso S, Fontana A. Protein Sci; 1999 Oct 10; 8(10):2213-7. PubMed ID: 10548068 [Abstract] [Full Text] [Related]