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198 related items for PubMed ID: 10997931

  • 1. Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.
    Nishino A, Kato Y, Igarashi T, Sugiyama Y.
    Drug Metab Dispos; 2000 Oct; 28(10):1146-8. PubMed ID: 10997931
    [Abstract] [Full Text] [Related]

  • 2. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
    Ishizuka H, Konno K, Naganuma H, Sasahara K, Kawahara Y, Niinuma K, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Mar; 280(3):1304-11. PubMed ID: 9067317
    [Abstract] [Full Text] [Related]

  • 3. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
    Sasabe H, Tsuji A, Sugiyama Y.
    J Pharmacol Exp Ther; 1998 Mar; 284(3):1033-9. PubMed ID: 9495864
    [Abstract] [Full Text] [Related]

  • 4. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
    Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Apr; 281(1):304-14. PubMed ID: 9103511
    [Abstract] [Full Text] [Related]

  • 5. Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide.
    Yamada T, Niinuma K, Lemaire M, Terasaki T, Sugiyama Y.
    J Pharmacol Exp Ther; 1996 Dec; 279(3):1357-64. PubMed ID: 8968360
    [Abstract] [Full Text] [Related]

  • 6. Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats.
    Gotoh Y, Suzuki H, Kinoshita S, Hirohashi T, Kato Y, Sugiyama Y.
    J Pharmacol Exp Ther; 2000 Jan; 292(1):433-9. PubMed ID: 10604980
    [Abstract] [Full Text] [Related]

  • 7. Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2.
    Morikawa A, Goto Y, Suzuki H, Hirohashi T, Sugiyama Y.
    Pharm Res; 2000 May; 17(5):546-52. PubMed ID: 10888306
    [Abstract] [Full Text] [Related]

  • 8. Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
    Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Aug; 282(2):866-72. PubMed ID: 9262353
    [Abstract] [Full Text] [Related]

  • 9. Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats.
    Takenaka O, Horie T, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1995 Sep; 274(3):1362-9. PubMed ID: 7562509
    [Abstract] [Full Text] [Related]

  • 10. Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats.
    Yamazaki M, Kobayashi K, Sugiyama Y.
    Biopharm Drug Dispos; 1996 Oct; 17(7):607-21. PubMed ID: 8894118
    [Abstract] [Full Text] [Related]

  • 11. Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent.
    Murata M, Tamai I, Sai Y, Nagata O, Kato H, Sugiyama Y, Tsuji A.
    Drug Metab Dispos; 1998 Nov; 26(11):1113-9. PubMed ID: 9806954
    [Abstract] [Full Text] [Related]

  • 12. Reduced folate derivatives are endogenous substrates for cMOAT in rats.
    Kusuhara H, Han YH, Shimoda M, Kokue E, Suzuki H, Sugiyama Y.
    Am J Physiol; 1998 Oct; 275(4):G789-96. PubMed ID: 9756510
    [Abstract] [Full Text] [Related]

  • 13. Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats.
    Yamazaki M, Kobayashi K, Sugiyama Y.
    Biopharm Drug Dispos; 1996 Nov; 17(8):645-59. PubMed ID: 8950045
    [Abstract] [Full Text] [Related]

  • 14. Pharmacokinetic study of the hepatobiliary transport of indomethacin.
    Kouzuki H, Suzuki H, Sugiyama Y.
    Pharm Res; 2000 Apr; 17(4):432-8. PubMed ID: 10870987
    [Abstract] [Full Text] [Related]

  • 15. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
    Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y.
    Am J Physiol; 1997 Jan; 272(1 Pt 1):G16-22. PubMed ID: 9038871
    [Abstract] [Full Text] [Related]

  • 16. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.
    Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T, Sugiyama Y.
    Mol Pharmacol; 1998 Jun; 53(6):1068-75. PubMed ID: 9614210
    [Abstract] [Full Text] [Related]

  • 17. Impaired biliary excretion and whole body elimination of methylmercury in rats with congenital defect in biliary glutathione excretion.
    Ballatori N, Gatmaitan Z, Truong AT.
    Hepatology; 1995 Nov; 22(5):1469-73. PubMed ID: 7590665
    [Abstract] [Full Text] [Related]

  • 18. Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TR- and EHBR rats.
    Newton DJ, Wang RW, Evans DC.
    Life Sci; 2005 Jul 22; 77(10):1106-15. PubMed ID: 15913659
    [Abstract] [Full Text] [Related]

  • 19. Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
    Johnson DR, Habeebu SS, Klaassen CD.
    Toxicol Sci; 2002 Mar 22; 66(1):16-26. PubMed ID: 11861969
    [Abstract] [Full Text] [Related]

  • 20. Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat.
    Sasabe H, Kato Y, Tsuji A, Sugiyama Y.
    J Pharmacol Exp Ther; 1998 Feb 22; 284(2):661-8. PubMed ID: 9454812
    [Abstract] [Full Text] [Related]

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