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165 related items for PubMed ID: 11006278

  • 1. Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2).
    Smith T, McCracken J, Shin YK, DeWitt D.
    J Biol Chem; 2000 Dec 22; 275(51):40407-15. PubMed ID: 11006278
    [Abstract] [Full Text] [Related]

  • 2. The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs.
    Greig GM, Francis DA, Falgueyret JP, Ouellet M, Percival MD, Roy P, Bayly C, Mancini JA, O'Neill GP.
    Mol Pharmacol; 1997 Nov 22; 52(5):829-38. PubMed ID: 9351974
    [Abstract] [Full Text] [Related]

  • 3. Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2.
    Xiao G, Tsai AL, Palmer G, Boyar WC, Marshall PJ, Kulmacz RJ.
    Biochemistry; 1997 Feb 18; 36(7):1836-45. PubMed ID: 9048568
    [Abstract] [Full Text] [Related]

  • 4. Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.
    Rogge CE, Liu W, Wu G, Wang LH, Kulmacz RJ, Tsai AL.
    Biochemistry; 2004 Feb 17; 43(6):1560-8. PubMed ID: 14769032
    [Abstract] [Full Text] [Related]

  • 5. Molecular modelling of the differential interaction between several non-steroidal anti-inflammatory drugs and human prostaglandin endoperoxide H synthase-2 (h-PGHS-2).
    Pouplana R, Lozano JJ, Ruiz J.
    J Mol Graph Model; 2002 Jan 17; 20(4):329-43. PubMed ID: 11858641
    [Abstract] [Full Text] [Related]

  • 6. The structures of prostaglandin endoperoxide H synthases-1 and -2.
    Garavito RM, Malkowski MG, DeWitt DL.
    Prostaglandins Other Lipid Mediat; 2002 Aug 17; 68-69():129-52. PubMed ID: 12432914
    [Abstract] [Full Text] [Related]

  • 7. Structure-based QSAR study on differential inhibition of human prostaglandin endoperoxide H synthase-2 (COX-2) by nonsteroidal anti-inflammatory drugs.
    Pouplana R, Lozano JJ, Pérez C, Ruiz J.
    J Comput Aided Mol Des; 2002 Oct 17; 16(10):683-709. PubMed ID: 12650588
    [Abstract] [Full Text] [Related]

  • 8. Purification and characterization of the human recombinant histidine-tagged prostaglandin endoperoxide H synthases-1 and -2.
    Smith T, Leipprandt J, DeWitt D.
    Arch Biochem Biophys; 2000 Mar 01; 375(1):195-200. PubMed ID: 10683267
    [Abstract] [Full Text] [Related]

  • 9. Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.
    Bhattacharyya DK, Lecomte M, Rieke CJ, Garavito M, Smith WL.
    J Biol Chem; 1996 Jan 26; 271(4):2179-84. PubMed ID: 8567676
    [Abstract] [Full Text] [Related]

  • 10. Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells.
    Wong E, DeLuca C, Boily C, Charleson S, Cromlish W, Denis D, Kargman S, Kennedy BP, Ouellet M, Skorey K, O'Neill GP, Vickers PJ, Riendeau D.
    Inflamm Res; 1997 Feb 26; 46(2):51-9. PubMed ID: 9085144
    [Abstract] [Full Text] [Related]

  • 11. O-acetylsalicylhydroxamic acid, a novel acetylating inhibitor of prostaglandin H2 synthase: structural and functional characterization of enzyme-inhibitor interactions.
    Loll PJ, Sharkey CT, O'Connor SJ, Dooley CM, O'Brien E, Devocelle M, Nolan KB, Selinsky BS, Fitzgerald DJ.
    Mol Pharmacol; 2001 Dec 26; 60(6):1407-13. PubMed ID: 11723249
    [Abstract] [Full Text] [Related]

  • 12. Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid.
    Thuresson ED, Lakkides KM, Rieke CJ, Sun Y, Wingerd BA, Micielli R, Mulichak AM, Malkowski MG, Garavito RM, Smith WL.
    J Biol Chem; 2001 Mar 30; 276(13):10347-57. PubMed ID: 11121412
    [Abstract] [Full Text] [Related]

  • 13. The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors.
    Rieke CJ, Mulichak AM, Garavito RM, Smith WL.
    J Biol Chem; 1999 Jun 11; 274(24):17109-14. PubMed ID: 10358065
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
    Loll PJ, Picot D, Ekabo O, Garavito RM.
    Biochemistry; 1996 Jun 11; 35(23):7330-40. PubMed ID: 8652509
    [Abstract] [Full Text] [Related]

  • 15. Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2.
    Tsai AL, Palmer G, Wu G, Peng S, Okeley NM, van der Donk WA, Kulmacz RJ.
    J Biol Chem; 2002 Oct 11; 277(41):38311-21. PubMed ID: 12167656
    [Abstract] [Full Text] [Related]

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  • 17. The productive conformation of arachidonic acid bound to prostaglandin synthase.
    Malkowski MG, Ginell SL, Smith WL, Garavito RM.
    Science; 2000 Sep 15; 289(5486):1933-7. PubMed ID: 10988074
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  • 20. Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.
    Smith WL, DeWitt DL.
    Semin Nephrol; 1995 May 15; 15(3):179-94. PubMed ID: 7631045
    [Abstract] [Full Text] [Related]

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