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235 related items for PubMed ID: 11006363

  • 1. Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
    Chen C, Hennig GE, Whiteley HE, Corton JC, Manautou JE.
    Toxicol Sci; 2000 Oct; 57(2):338-44. PubMed ID: 11006363
    [Abstract] [Full Text] [Related]

  • 2. Protection against acetaminophen hepatotoxicity by a single dose of clofibrate: effects on selective protein arylation and glutathione depletion.
    Manautou JE, Emeigh Hart SG, Khairallah EA, Cohen SD.
    Fundam Appl Toxicol; 1996 Feb; 29(2):229-37. PubMed ID: 8742320
    [Abstract] [Full Text] [Related]

  • 3. The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.
    Nguyen KA, Carbone JM, Silva VM, Chen C, Hennig GE, Whiteley HE, Manautou JE.
    J Toxicol Environ Health A; 1999 Oct 15; 58(3):171-86. PubMed ID: 10522648
    [Abstract] [Full Text] [Related]

  • 4. Clofibrate pretreatment diminishes acetaminophen's selective covalent binding and hepatotoxicity.
    Manautou JE, Hoivik DJ, Tveit A, Hart SG, Khairallah EA, Cohen SD.
    Toxicol Appl Pharmacol; 1994 Dec 15; 129(2):252-63. PubMed ID: 7992315
    [Abstract] [Full Text] [Related]

  • 5. Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction.
    Chen C, Hennig GE, Whiteley HE, Manautou JE.
    J Biochem Mol Toxicol; 2002 Dec 15; 16(5):227-34. PubMed ID: 12439864
    [Abstract] [Full Text] [Related]

  • 6. Protection by clofibrate against acetaminophen hepatotoxicity in male CD-1 mice is associated with an early increase in biliary concentration of acetaminophen-glutathione adducts.
    Manautou JE, Tveit A, Hoivik DJ, Khairallah EA, Cohen SD.
    Toxicol Appl Pharmacol; 1996 Sep 15; 140(1):30-8. PubMed ID: 8806867
    [Abstract] [Full Text] [Related]

  • 7. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate.
    Moffit JS, Koza-Taylor PH, Holland RD, Thibodeau MS, Beger RD, Lawton MP, Manautou JE.
    Toxicol Appl Pharmacol; 2007 Jul 15; 222(2):169-79. PubMed ID: 17585979
    [Abstract] [Full Text] [Related]

  • 8. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice.
    Manautou JE, Silva VM, Hennig GE, Whiteley HE.
    Toxicology; 1998 May 15; 127(1-3):1-10. PubMed ID: 9699788
    [Abstract] [Full Text] [Related]

  • 9. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.
    Moffit JS, Aleksunes LM, Kardas MJ, Slitt AL, Klaassen CD, Manautou JE.
    Toxicology; 2007 Feb 12; 230(2-3):197-206. PubMed ID: 17188792
    [Abstract] [Full Text] [Related]

  • 10. PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.
    Mehendale HM.
    Toxicol Sci; 2000 Oct 12; 57(2):187-90. PubMed ID: 11006348
    [Abstract] [Full Text] [Related]

  • 11. Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.
    Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ.
    Hepatology; 2012 Jul 12; 56(1):281-90. PubMed ID: 22318764
    [Abstract] [Full Text] [Related]

  • 12. Clofibrate-induced in vitro hepatoprotection against acetaminophen is not due to altered glutathione homeostasis.
    Nicholls-Grzemski FA, Calder IC, Priestly BG, Burcham PC.
    Toxicol Sci; 2000 Jul 12; 56(1):220-8. PubMed ID: 10869471
    [Abstract] [Full Text] [Related]

  • 13. Changes in susceptibility to acetaminophen-induced liver injury by the organic anion indocyanine green.
    Silva VM, Chen C, Hennig GE, Whiteley HE, Manautou JE.
    Food Chem Toxicol; 2001 Mar 12; 39(3):271-8. PubMed ID: 11278059
    [Abstract] [Full Text] [Related]

  • 14. Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate.
    Donthamsetty S, Bhave VS, Mitra MS, Latendresse JR, Mehendale HM.
    Toxicol Appl Pharmacol; 2008 Aug 01; 230(3):327-37. PubMed ID: 18501395
    [Abstract] [Full Text] [Related]

  • 15. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
    Zaher H, Buters JT, Ward JM, Bruno MK, Lucas AM, Stern ST, Cohen SD, Gonzalez FJ.
    Toxicol Appl Pharmacol; 1998 Sep 01; 152(1):193-9. PubMed ID: 9772215
    [Abstract] [Full Text] [Related]

  • 16. Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice.
    Arakawa S, Maejima T, Fujimoto K, Yamaguchi T, Yagi M, Sugiura T, Atsumi R, Yamazoe Y.
    J Toxicol Sci; 2012 Sep 01; 37(3):595-605. PubMed ID: 22687999
    [Abstract] [Full Text] [Related]

  • 17. Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.
    Ferreira DW, Goedken MJ, Rommelaere S, Chasson L, Galland F, Naquet P, Manautou JE.
    Biochim Biophys Acta; 2016 Apr 01; 1862(4):662-669. PubMed ID: 26850476
    [Abstract] [Full Text] [Related]

  • 18. Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.
    Chen C, Krausz KW, Shah YM, Idle JR, Gonzalez FJ.
    Chem Res Toxicol; 2009 Apr 01; 22(4):699-707. PubMed ID: 19256530
    [Abstract] [Full Text] [Related]

  • 19. Hepatic hypoxia-inducible factors inhibit PPARα expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity.
    Li D, Du Y, Yuan X, Han X, Dong Z, Chen X, Wu H, Zhang J, Xu L, Han C, Zhang M, Xia Q.
    Free Radic Biol Med; 2017 Sep 01; 110():102-116. PubMed ID: 28583670
    [Abstract] [Full Text] [Related]

  • 20. Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
    Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T.
    Pharmacol Res; 2014 Sep 01; 87():26-41. PubMed ID: 24951965
    [Abstract] [Full Text] [Related]

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