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327 related items for PubMed ID: 11021592

  • 1. Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV).
    Degrève B, De Clercq E, Balzarini J.
    Gene Ther; 2000 Sep; 7(18):1543-52. PubMed ID: 11021592
    [Abstract] [Full Text] [Related]

  • 2. Highly selective cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine derivatives for murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Seno T.
    Mol Pharmacol; 1985 Dec; 28(6):581-7. PubMed ID: 3001499
    [Abstract] [Full Text] [Related]

  • 3. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene.
    Balzarini J, De Clercq E, Verbruggen A, Ayusawa D, Shimizu K, Seno T.
    Mol Pharmacol; 1987 Sep; 32(3):410-6. PubMed ID: 2823092
    [Abstract] [Full Text] [Related]

  • 4. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells.
    Balzarini J, Bohman C, Walker RT, de Clercq E.
    Mol Pharmacol; 1994 Jun; 45(6):1253-8. PubMed ID: 8022417
    [Abstract] [Full Text] [Related]

  • 5. Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells.
    Balzarini J, Degrève B, Andrei G, Neyts J, Sandvold M, Myhren F, de Clercq E.
    Gene Ther; 1998 Mar; 5(3):419-26. PubMed ID: 9614564
    [Abstract] [Full Text] [Related]

  • 6. Increased sensitivity of thymidine kinase-deficient (TK-) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds.
    Balzarini J, De Clercq E, Verbruggen A, Crumpacker C, Ayusawa D, Seno T.
    Anticancer Res; 1986 Mar; 6(5):1077-84. PubMed ID: 2432829
    [Abstract] [Full Text] [Related]

  • 7. (E)-5-(2-bromovinyl)-2'-deoxyuridine potentiates ganciclovir-mediated cytotoxicity on herpes simplex virus-thymidine kinase--expressing cells.
    Hamel W, Zirkel D, Mehdorn HM, Westphal M, Israel MA.
    Cancer Gene Ther; 2001 May; 8(5):388-96. PubMed ID: 11477459
    [Abstract] [Full Text] [Related]

  • 8. Carbocyclic 5-iodo-2'-deoxyuridine (C-IDU) and carbocyclic (E)-5-(2-bromovinyl)-2'-deoxyuridine (C-BVDU) as unique examples of chiral molecules where the two enantiomeric forms are biologically active: interaction of the (+)- and (-)-enantiomers of C-IDU and C-BVDU with the thymidine kinase of herpes simplex virus type 1.
    Balzarini J, De Clercq E, Baumgartner H, Bodenteich M, Griengl H.
    Mol Pharmacol; 1990 Mar; 37(3):395-401. PubMed ID: 2156153
    [Abstract] [Full Text] [Related]

  • 9. Novel (E)-5-(2-iodovinyl)-2'-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors.
    Balzarini J, Morin KW, Knaus EE, Wiebe LI, De Clercq E.
    Gene Ther; 1995 Jul; 2(5):317-22. PubMed ID: 7671107
    [Abstract] [Full Text] [Related]

  • 10. Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects and sensitivity to ganciclovir.
    Howard BD, Boenicke L, Schniewind B, Henne-Bruns D, Kalthoff H.
    Cancer Gene Ther; 2000 Jun; 7(6):927-38. PubMed ID: 10880025
    [Abstract] [Full Text] [Related]

  • 11. [Bystander effect mediated by herpes simplex virus-thymidine kinase/ganciclovir approach on prostatic cancer cells and its regulation].
    Xing Y, Lu G, Xiao Y, Zeng F, Zhang Q, Xiong P, Feng W.
    Zhonghua Yi Xue Za Zhi; 2002 Nov 10; 82(21):1484-7. PubMed ID: 12509912
    [Abstract] [Full Text] [Related]

  • 12. Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
    Degrève B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI, Basrah I, Walker RT, De Clercq E, Balzarini J.
    Gene Ther; 1997 Oct 10; 4(10):1107-14. PubMed ID: 9415318
    [Abstract] [Full Text] [Related]

  • 13. Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase.
    Grignet-Debrus C, Cool V, Baudson N, Degrève B, Balzarini J, De Leval L, Debrus S, Velu T, Calberg-Bacq CM.
    Cancer Gene Ther; 2000 Feb 10; 7(2):215-23. PubMed ID: 10770629
    [Abstract] [Full Text] [Related]

  • 14. [Herpes simplex virus type 1 thymidine kinase/ganciclovir (HSV(1)-TK/GCV) system as an effective "in vivo death switch" of live tumor vaccines].
    Kang Y, Xu CJ, Liu XS, Wu CQ, Zhong CP, Gu JR.
    Ai Zheng; 2005 Aug 10; 24(8):909-14. PubMed ID: 16086864
    [Abstract] [Full Text] [Related]

  • 15. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2.
    Balzarini J, Bohman C, De Clercq E.
    J Biol Chem; 1993 Mar 25; 268(9):6332-7. PubMed ID: 8384209
    [Abstract] [Full Text] [Related]

  • 16. Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues.
    Degrève B, De Clercq E, Balzarini J.
    Gene Ther; 1999 Feb 25; 6(2):162-70. PubMed ID: 10435100
    [Abstract] [Full Text] [Related]

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  • 19. Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
    Degrève B, Esnouf R, De Clercq E, Balzarini J.
    Mol Pharmacol; 2001 Feb 25; 59(2):285-93. PubMed ID: 11160865
    [Abstract] [Full Text] [Related]

  • 20. 5-Iodo-2'-deoxy-L-uridine and (E)-5-(2-bromovinyl)-2'-deoxy-L-uridine: selective phosphorylation by herpes simplex virus type 1 thymidine kinase, antiherpetic activity, and cytotoxicity studies.
    Spadari S, Ciarrocchi G, Focher F, Verri A, Maga G, Arcamone F, Iafrate E, Manzini S, Garbesi A, Tondelli L.
    Mol Pharmacol; 1995 Jun 25; 47(6):1231-8. PubMed ID: 7603465
    [Abstract] [Full Text] [Related]

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