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Journal Abstract Search

223 related items for PubMed ID: 11048954

  • 1. Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution.
    Dang T, Prestwich GD.
    Chem Biol; 2000 Aug; 7(8):643-9. PubMed ID: 11048954
    [Abstract] [Full Text] [Related]

  • 2. Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene.
    Hoshino T, Shimizu K, Sato T.
    Angew Chem Int Ed Engl; 2004 Dec 10; 43(48):6700-3. PubMed ID: 15593147
    [No Abstract] [Full Text] [Related]

  • 3. Alicyclobacillus acidocaldarius Squalene-Hopene Cyclase: The Critical Role of Steric Bulk at Ala306 and the First Enzymatic Synthesis of Epoxydammarane from 2,3-Oxidosqualene.
    Ideno N, Umeyama S, Watanabe T, Nakajima M, Sato T, Hoshino T.
    Chembiochem; 2018 Sep 04; 19(17):1873-1886. PubMed ID: 29911308
    [Abstract] [Full Text] [Related]

  • 4. Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.
    Sato T, Kouda M, Hoshino T.
    Biosci Biotechnol Biochem; 2004 Mar 04; 68(3):728-38. PubMed ID: 15056909
    [Abstract] [Full Text] [Related]

  • 5. Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.
    Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A.
    Org Biomol Chem; 2004 May 21; 2(10):1456-70. PubMed ID: 15136801
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071.
    Lenhart A, Weihofen WA, Pleschke AE, Schulz GE.
    Chem Biol; 2002 May 21; 9(5):639-45. PubMed ID: 12031670
    [Abstract] [Full Text] [Related]

  • 7. Bicyclic triterpenes as new main products of squalene-hopene cyclase by mutation at conserved tyrosine residues.
    Füll C.
    FEBS Lett; 2001 Dec 14; 509(3):361-4. PubMed ID: 11749956
    [Abstract] [Full Text] [Related]

  • 8. Rationally designed inhibitors as tools for comparing the mechanism of squalene-hopene cyclase with oxidosqualene cyclase.
    Viola F, Ceruti M, Cattel L, Milla P, Poralla K, Balliano G.
    Lipids; 2000 Mar 14; 35(3):297-303. PubMed ID: 10783007
    [Abstract] [Full Text] [Related]

  • 9. Squalene-hopene cyclase (Spterp25) from Streptomyces peucetius: sequence analysis, expression and functional characterization.
    Ghimire GP, Oh TJ, Lee HC, Sohng JK.
    Biotechnol Lett; 2009 Apr 14; 31(4):565-9. PubMed ID: 19116691
    [Abstract] [Full Text] [Related]

  • 10. Profound insights into squalene cyclization.
    Poralla K.
    Chem Biol; 2004 Jan 14; 11(1):12-4. PubMed ID: 15112988
    [Abstract] [Full Text] [Related]

  • 11. Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis.
    Hammer SC, Marjanovic A, Dominicus JM, Nestl BM, Hauer B.
    Nat Chem Biol; 2015 Feb 14; 11(2):121-6. PubMed ID: 25503928
    [Abstract] [Full Text] [Related]

  • 12. Site-directed mutagenesis of putative active-site residues in squalene-hopene cyclase.
    Feil C, Süssmuth R, Jung G, Poralla K.
    Eur J Biochem; 1996 Nov 15; 242(1):51-5. PubMed ID: 8954152
    [Abstract] [Full Text] [Related]

  • 13. The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling.
    Dang T, Abe I, Zheng YF, Prestwich GD.
    Chem Biol; 1999 Jun 15; 6(6):333-41. PubMed ID: 10375539
    [Abstract] [Full Text] [Related]

  • 14. Reviewing the polyolefin cyclization reaction of the c(35) polyprene catalyzed by squalene-hopene cyclase.
    Hoshino T, Kumai Y, Sato T.
    Chemistry; 2009 Jun 15; 15(9):2091-100. PubMed ID: 19142932
    [Abstract] [Full Text] [Related]

  • 15. Squalene-hopene cyclases.
    Siedenburg G, Jendrossek D.
    Appl Environ Microbiol; 2011 Jun 15; 77(12):3905-15. PubMed ID: 21531832
    [Abstract] [Full Text] [Related]

  • 16. Mechanistic insights into oxidosqualene cyclizations through homology modeling.
    Schulz-Gasch T, Stahl M.
    J Comput Chem; 2003 Apr 30; 24(6):741-53. PubMed ID: 12666166
    [Abstract] [Full Text] [Related]

  • 17. Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.
    Ito R, Masukawa Y, Hoshino T.
    FEBS J; 2013 Mar 30; 280(5):1267-80. PubMed ID: 23294602
    [Abstract] [Full Text] [Related]

  • 18. Concerted nature of AB ring formation in the enzymatic cyclization of squalene to hopenes.
    Hess BA, Smentek L.
    Org Lett; 2004 May 27; 6(11):1717-20. PubMed ID: 15151397
    [Abstract] [Full Text] [Related]

  • 19. Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.
    Segura MJ, Meyer MM, Matsuda SP.
    Org Lett; 2000 Jul 27; 2(15):2257-9. PubMed ID: 10930257
    [Abstract] [Full Text] [Related]

  • 20. New cyclization mechanism for squalene: a ring-expansion step for the five-membered C-ring intermediate in hopene biosynthesis.
    Hoshino T, Kouda M, Abe T, Ohashi S.
    Biosci Biotechnol Biochem; 1999 Nov 27; 63(11):2038-41. PubMed ID: 10635573
    [Abstract] [Full Text] [Related]

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