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95 related items for PubMed ID: 11106258

  • 1. The importance of p53-independent apoptosis in the intestinal toxicity induced by raltitrexed (ZD1694, Tomudex): genetic differences between BALB/c and DBA/2 mice.
    Pritchard DM, Bower L, Potten CS, Jackman AL, Hickman JA.
    Clin Cancer Res; 2000 Nov; 6(11):4389-95. PubMed ID: 11106258
    [Abstract] [Full Text] [Related]

  • 2. Balb/c mice as a preclinical model for raltitrexed-induced gastrointestinal toxicity.
    Clarke SJ, Farrugia DC, Aherne GW, Pritchard DM, Benstead J, Jackman AL.
    Clin Cancer Res; 2000 Jan; 6(1):285-96. PubMed ID: 10656460
    [Abstract] [Full Text] [Related]

  • 3. The relationships between p53-dependent apoptosis, inhibition of proliferation, and 5-fluorouracil-induced histopathology in murine intestinal epithelia.
    Pritchard DM, Potten CS, Hickman JA.
    Cancer Res; 1998 Dec 01; 58(23):5453-65. PubMed ID: 9850079
    [Abstract] [Full Text] [Related]

  • 4. Leucovorin rescue from raltitrexed (tomudex)-induced antiproliferative effects: in vitro cell line and in vivo mouse studies.
    Farrugia DC, Aherne GW, Brunton L, Clarke SJ, Jackman AL.
    Clin Cancer Res; 2000 Sep 01; 6(9):3646-56. PubMed ID: 10999757
    [Abstract] [Full Text] [Related]

  • 5. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation.
    Merritt AJ, Allen TD, Potten CS, Hickman JA.
    Oncogene; 1997 Jun 12; 14(23):2759-66. PubMed ID: 9190891
    [Abstract] [Full Text] [Related]

  • 6. Differential post-translational modification of the tumour suppressor proteins Rb and p53 modulate the rates of radiation-induced apoptosis in vivo.
    Wallace M, Coates PJ, Wright EG, Ball KL.
    Oncogene; 2001 Jun 21; 20(28):3597-608. PubMed ID: 11439323
    [Abstract] [Full Text] [Related]

  • 7. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.
    Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, Hall PA.
    Cancer Res; 1994 Feb 01; 54(3):614-7. PubMed ID: 8306319
    [Abstract] [Full Text] [Related]

  • 8. Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity.
    Pritchard DM, Jackman A, Potten CS, Hickman JA.
    Toxicol Lett; 1998 Dec 28; 102-103():19-27. PubMed ID: 10022227
    [Abstract] [Full Text] [Related]

  • 9. The impact of p53 status on cellular sensitivity to antifolate drugs.
    Lu X, Errington J, Curtin NJ, Lunec J, Newell DR.
    Clin Cancer Res; 2001 Jul 28; 7(7):2114-23. PubMed ID: 11448931
    [Abstract] [Full Text] [Related]

  • 10. The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
    Longley DB, Allen WL, McDermott U, Wilson TR, Latif T, Boyer J, Lynch M, Johnston PG.
    Clin Cancer Res; 2004 May 15; 10(10):3562-71. PubMed ID: 15161716
    [Abstract] [Full Text] [Related]

  • 11. Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
    Avallone A, Di Gennaro E, Bruzzese F, Laus G, Delrio P, Caraglia M, Pepe S, Comella P, Budillon A.
    Anticancer Drugs; 2007 Aug 15; 18(7):781-91. PubMed ID: 17581300
    [Abstract] [Full Text] [Related]

  • 12. Gene expression and apoptosis induction in p53-heterozygous irradiated mice.
    di Masi A, Antoccia A, Dimauro I, Argentino-Storino A, Mosiello A, Mango R, Novelli G, Tanzarella C.
    Mutat Res; 2006 Feb 22; 594(1-2):49-62. PubMed ID: 16169021
    [Abstract] [Full Text] [Related]

  • 13. Overexpression of Bax enhances antitumor activity of chemotherapeutic agents in human head and neck squamous cell carcinoma.
    Guo B, Cao S, Tóth K, Azrak RG, Rustum YM.
    Clin Cancer Res; 2000 Feb 22; 6(2):718-24. PubMed ID: 10690558
    [Abstract] [Full Text] [Related]

  • 14. Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment.
    Adamsen BL, Kravik KL, Clausen OP, De Angelis PM.
    Int J Oncol; 2007 Dec 22; 31(6):1491-500. PubMed ID: 17982676
    [Abstract] [Full Text] [Related]

  • 15. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
    Peters GJ, van Triest B, Backus HH, Kuiper CM, van der Wilt CL, Pinedo HM.
    Eur J Cancer; 2000 May 22; 36(7):916-24. PubMed ID: 10785598
    [Abstract] [Full Text] [Related]

  • 16. p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent.
    Kemp CJ, Sun S, Gurley KE.
    Cancer Res; 2001 Jan 01; 61(1):327-32. PubMed ID: 11196181
    [Abstract] [Full Text] [Related]

  • 17. c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.
    Arango D, Corner GA, Wadler S, Catalano PJ, Augenlicht LH.
    Cancer Res; 2001 Jun 15; 61(12):4910-5. PubMed ID: 11406570
    [Abstract] [Full Text] [Related]

  • 18. Pharmacokinetics studies and toxicity profile of raltitrexed used by intraperitoneal route in normothermia in a pig model.
    Nguyen D, Emond C, Leclerc Y, Sherman I, Dube P.
    Med Sci Monit; 2003 Jan 15; 9(1):BR37-42. PubMed ID: 12552235
    [Abstract] [Full Text] [Related]

  • 19. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
    Longley DB, Boyer J, Allen WL, Latif T, Ferguson PR, Maxwell PJ, McDermott U, Lynch M, Harkin DP, Johnston PG.
    Cancer Res; 2002 May 01; 62(9):2644-9. PubMed ID: 11980662
    [Abstract] [Full Text] [Related]

  • 20. Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
    van der Wilt CL, Backus HH, Smid K, Comijn L, Veerman G, Wouters D, Voorn DA, Priest DG, Bunni MA, Mitchell F, Jackman AL, Jansen G, Peters GJ.
    Cancer Res; 2001 May 01; 61(9):3675-81. PubMed ID: 11325838
    [Abstract] [Full Text] [Related]

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