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506 related items for PubMed ID: 11134556

  • 1. High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.
    Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, Yamamoto M.
    Toxicol Sci; 2001 Jan; 59(1):169-77. PubMed ID: 11134556
    [Abstract] [Full Text] [Related]

  • 2. Hepatoprotective Activity of Yellow Chinese Chive against Acetaminophen-Induced Acute Liver Injury via Nrf2 Signaling Pathway.
    Kawakami K, Moritani C, Hatanaka T, Suzaki E, Tsuboi S.
    J Nutr Sci Vitaminol (Tokyo); 2020 Jan; 66(4):357-363. PubMed ID: 32863309
    [Abstract] [Full Text] [Related]

  • 3. Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
    Randle LE, Goldring CE, Benson CA, Metcalfe PN, Kitteringham NR, Park BK, Williams DP.
    Toxicology; 2008 Jan 20; 243(3):249-60. PubMed ID: 18078705
    [Abstract] [Full Text] [Related]

  • 4. Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
    Dambach DM, Durham SK, Laskin JD, Laskin DL.
    Toxicol Appl Pharmacol; 2006 Mar 01; 211(2):157-65. PubMed ID: 16081117
    [Abstract] [Full Text] [Related]

  • 5. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
    Kwak MK, Itoh K, Yamamoto M, Sutter TR, Kensler TW.
    Mol Med; 2001 Feb 01; 7(2):135-45. PubMed ID: 11471548
    [Abstract] [Full Text] [Related]

  • 6. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein.
    Chan JY, Kwong M.
    Biochim Biophys Acta; 2000 Dec 15; 1517(1):19-26. PubMed ID: 11118612
    [Abstract] [Full Text] [Related]

  • 7. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen.
    Chan K, Han XD, Kan YW.
    Proc Natl Acad Sci U S A; 2001 Apr 10; 98(8):4611-6. PubMed ID: 11287661
    [Abstract] [Full Text] [Related]

  • 8. Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways.
    Lin M, Zhai X, Wang G, Tian X, Gao D, Shi L, Wu H, Fan Q, Peng J, Liu K, Yao J.
    J Pharmacol Sci; 2015 Feb 10; 127(2):203-10. PubMed ID: 25727958
    [Abstract] [Full Text] [Related]

  • 9. Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
    Shimizu D, Ishitsuka Y, Miyata K, Tomishima Y, Kondo Y, Irikura M, Iwawaki T, Oike Y, Irie T.
    Pharmacol Res; 2014 Sep 10; 87():26-41. PubMed ID: 24951965
    [Abstract] [Full Text] [Related]

  • 10. Hepatocyte-Specific Deficiency of DAX-1 Protects Mice from Acetaminophen-Induced Hepatotoxicity by Activating NRF2 Signaling.
    Suh YJ, Yun HJ, Kim YB, Kang EJ, Choi JH, Choi YK, Lee IB, Choi DH, Seo YJ, Noh JR, Lee JS, Kim YH, Lee CH.
    Int J Mol Sci; 2022 Oct 04; 23(19):. PubMed ID: 36233086
    [Abstract] [Full Text] [Related]

  • 11. Upregulation of Nrf2-related cytoprotective genes expression by acetaminophen-induced acute hepatotoxicity in mice and the protective role of betaine.
    Khodayar MJ, Kalantari H, Khorsandi L, Rashno M, Zeidooni L.
    Hum Exp Toxicol; 2020 Jul 04; 39(7):948-959. PubMed ID: 32081044
    [Abstract] [Full Text] [Related]

  • 12. Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
    Patterson AD, Carlson BA, Li F, Bonzo JA, Yoo MH, Krausz KW, Conrad M, Chen C, Gonzalez FJ, Hatfield DL.
    Chem Res Toxicol; 2013 Jul 15; 26(7):1088-96. PubMed ID: 23697945
    [Abstract] [Full Text] [Related]

  • 13. Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.
    Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE.
    Toxicol Appl Pharmacol; 2008 Jan 01; 226(1):74-83. PubMed ID: 17935745
    [Abstract] [Full Text] [Related]

  • 14. Efficacy of oltipraz in preventing acetaminophen-induced liver injury in mice.
    Masubuchi Y, Mikami K.
    Naunyn Schmiedebergs Arch Pharmacol; 2024 Feb 01; 397(2):923-930. PubMed ID: 37535075
    [Abstract] [Full Text] [Related]

  • 15. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.
    Jiang YM, Wang Y, Tan HS, Yu T, Fan XM, Chen P, Zeng H, Huang M, Bi HC.
    Acta Pharmacol Sin; 2016 Mar 01; 37(3):382-9. PubMed ID: 26806302
    [Abstract] [Full Text] [Related]

  • 16. Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
    Ghosh P, Magee N, Akakpo JY, Ahamed F, Eppler N, Jones E, Yu Y, He L, Lebofsky M, Dai H, Jaeschke H, Ding WX, Zhang Y.
    Toxicol Sci; 2023 Dec 21; 197(1):53-68. PubMed ID: 37792503
    [Abstract] [Full Text] [Related]

  • 17. Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
    Wei M, Zheng Z, Shi L, Jin Y, Ji L.
    Toxicol Sci; 2018 Mar 01; 162(1):99-112. PubMed ID: 29136249
    [Abstract] [Full Text] [Related]

  • 18. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
    Zaher H, Buters JT, Ward JM, Bruno MK, Lucas AM, Stern ST, Cohen SD, Gonzalez FJ.
    Toxicol Appl Pharmacol; 1998 Sep 01; 152(1):193-9. PubMed ID: 9772215
    [Abstract] [Full Text] [Related]

  • 19. Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?
    Rohrer PR, Rudraiah S, Goedken MJ, Manautou JE.
    Drug Metab Dispos; 2014 Oct 01; 42(10):1663-74. PubMed ID: 25092713
    [Abstract] [Full Text] [Related]

  • 20. Protective effect of hyperoside against acetaminophen (APAP) induced liver injury through enhancement of APAP clearance.
    Xie W, Jiang Z, Wang J, Zhang X, Melzig MF.
    Chem Biol Interact; 2016 Feb 25; 246():11-9. PubMed ID: 26772156
    [Abstract] [Full Text] [Related]

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