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Journal Abstract Search

223 related items for PubMed ID: 11145240

  • 1. Freeze-concentration separates proteins and polymer excipients into different amorphous phases.
    Izutsu K, Kojima S.
    Pharm Res; 2000 Oct; 17(10):1316-22. PubMed ID: 11145240
    [Abstract] [Full Text] [Related]

  • 2. Effect of polymer size and cosolutes on phase separation of poly(vinylpyrrolidone) (PVP) and dextran in frozen solutions.
    Izutsu K, Aoyagi N, Kojima S.
    J Pharm Sci; 2005 Apr; 94(4):709-17. PubMed ID: 15682383
    [Abstract] [Full Text] [Related]

  • 3. Amorphous-Amorphous Phase Separation of Freeze-Concentrated Protein and Amino Acid Excipients for Lyophilized Formulations.
    Izutsu KI, Yoshida H, Shibata H, Goda Y.
    Chem Pharm Bull (Tokyo); 2016 Apr; 64(12):1674-1680. PubMed ID: 27904076
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  • 4. Miscibility as a factor for component crystallization in multisolute frozen solutions.
    Izutsu KI, Shibata H, Yoshida H, Goda Y.
    J Pharm Sci; 2014 Jul; 103(7):2139-2146. PubMed ID: 24903048
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  • 6. Effect of cations and anions on glass transition temperatures in excipient solutions.
    Nesarikar VV, Nassar MN.
    Pharm Dev Technol; 2007 Jul; 12(3):259-64. PubMed ID: 17613889
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  • 8. Measurement of the kinetics of protein unfolding in viscous systems and implications for protein stability in freeze-drying.
    Tang XC, Pikal MJ.
    Pharm Res; 2005 Jul; 22(7):1176-85. PubMed ID: 16028019
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  • 11. Freeze-Drying From Organic Cosolvent Systems, Part 1: Thermal Analysis of Cosolvent-Based Placebo Formulations in the Frozen State.
    Kunz C, Schuldt-Lieb S, Gieseler H.
    J Pharm Sci; 2018 Mar; 107(3):887-896. PubMed ID: 29133233
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  • 12. Impact of heat treatment on the physical properties of noncrystalline multisolute systems concentrated in frozen aqueous solutions.
    Izutsu K, Yomota C, Kawanishi T.
    J Pharm Sci; 2011 Dec; 100(12):5244-53. PubMed ID: 21780120
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  • 13. Crystallization of mannitol below Tg' during freeze-drying in binary and ternary aqueous systems.
    Pyne A, Surana R, Suryanarayanan R.
    Pharm Res; 2002 Jun; 19(6):901-8. PubMed ID: 12134964
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  • 14. The study of phase separation in amorphous freeze-dried systems, part 2: investigation of Raman mapping as a tool for studying amorphous phase separation in freeze-dried protein formulations.
    Padilla AM, Pikal MJ.
    J Pharm Sci; 2011 Apr; 100(4):1467-74. PubMed ID: 20967837
    [Abstract] [Full Text] [Related]

  • 15. Method development and analysis of the water content of the maximally freeze concentrated solution suitable for protein lyophilisation.
    Seifert I, Bregolin A, Fissore D, Friess W.
    Eur J Pharm Biopharm; 2020 Aug; 153():36-42. PubMed ID: 32526356
    [Abstract] [Full Text] [Related]

  • 16. Formulations of sugars with amino acids or mannitol--influence of concentration ratio on the properties of the freeze-concentrate and the lyophilizate.
    Lueckel B, Bodmer D, Helk B, Leuenberger H.
    Pharm Dev Technol; 1998 Aug; 3(3):325-36. PubMed ID: 9742553
    [Abstract] [Full Text] [Related]

  • 17. Effect of counterions on the physical properties of l-arginine in frozen solutions and freeze-dried solids.
    Izutsu K, Fujimaki Y, Kuwabara A, Aoyagi N.
    Int J Pharm; 2005 Sep 14; 301(1-2):161-9. PubMed ID: 16026945
    [Abstract] [Full Text] [Related]

  • 18. A comparison of spray drying and milling in the production of amorphous dispersions of sulfathiazole/polyvinylpyrrolidone and sulfadimidine/polyvinylpyrrolidone.
    Caron V, Tajber L, Corrigan OI, Healy AM.
    Mol Pharm; 2011 Apr 04; 8(2):532-42. PubMed ID: 21323367
    [Abstract] [Full Text] [Related]

  • 19. Physical characterization of meso-erythritol as a crystalline bulking agent for freeze-dried formulations.
    Fujii K, Izutsu K, Kume M, Yoshino T, Yoshihashi Y, Sugano K, Terada K.
    Chem Pharm Bull (Tokyo); 2015 Apr 04; 63(5):311-7. PubMed ID: 25948324
    [Abstract] [Full Text] [Related]

  • 20. Effects of sugars and polymers on crystallization of poly(ethylene glycol) in frozen solutions: phase separation between incompatible polymers.
    Izutsu K, Yoshioka S, Kojima S, Randolph TW, Carpenter JF.
    Pharm Res; 1996 Sep 04; 13(9):1393-400. PubMed ID: 8893281
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