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247 related items for PubMed ID: 11148046

  • 1. Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 2001 Jan 16; 40(2):514-23. PubMed ID: 11148046
    [Abstract] [Full Text] [Related]

  • 2. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
    McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J.
    Biochemistry; 2005 Feb 01; 44(4):1106-13. PubMed ID: 15667204
    [Abstract] [Full Text] [Related]

  • 3. Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.
    Coggins BE, McClerren AL, Jiang L, Li X, Rudolph J, Hindsgaul O, Raetz CR, Zhou P.
    Biochemistry; 2005 Feb 01; 44(4):1114-26. PubMed ID: 15667205
    [Abstract] [Full Text] [Related]

  • 4. Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
    Jackman JE, Fierke CA, Tumey LN, Pirrung M, Uchiyama T, Tahir SH, Hindsgaul O, Raetz CR.
    J Biol Chem; 2000 Apr 14; 275(15):11002-9. PubMed ID: 10753902
    [Abstract] [Full Text] [Related]

  • 5. EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC).
    McClure CP, Rusche KM, Peariso K, Jackman JE, Fierke CA, Penner-Hahn JE.
    J Inorg Biochem; 2003 Feb 01; 94(1-2):78-85. PubMed ID: 12620676
    [Abstract] [Full Text] [Related]

  • 6. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 26; 45(51):15240-8. PubMed ID: 17176046
    [Abstract] [Full Text] [Related]

  • 7. Structure of the LpxC deacetylase with a bound substrate-analog inhibitor.
    Coggins BE, Li X, McClerren AL, Hindsgaul O, Raetz CR, Zhou P.
    Nat Struct Biol; 2003 Aug 26; 10(8):645-51. PubMed ID: 12833153
    [Abstract] [Full Text] [Related]

  • 8. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity.
    Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA.
    Biochemistry; 2010 Mar 16; 49(10):2246-55. PubMed ID: 20136146
    [Abstract] [Full Text] [Related]

  • 9. Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa.
    Mdluli KE, Witte PR, Kline T, Barb AW, Erwin AL, Mansfield BE, McClerren AL, Pirrung MC, Tumey LN, Warrener P, Raetz CR, Stover CK.
    Antimicrob Agents Chemother; 2006 Jun 16; 50(6):2178-84. PubMed ID: 16723580
    [Abstract] [Full Text] [Related]

  • 10. Mechanism and inhibition of LpxC: an essential zinc-dependent deacetylase of bacterial lipid A synthesis.
    Barb AW, Zhou P.
    Curr Pharm Biotechnol; 2008 Feb 16; 9(1):9-15. PubMed ID: 18289052
    [Abstract] [Full Text] [Related]

  • 11. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 1999 Feb 09; 38(6):1902-11. PubMed ID: 10026271
    [Abstract] [Full Text] [Related]

  • 12. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
    Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA.
    J Biol Chem; 2005 Apr 29; 280(17):16969-78. PubMed ID: 15705580
    [Abstract] [Full Text] [Related]

  • 13. Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 12; 45(49):14573-81. PubMed ID: 17144651
    [Abstract] [Full Text] [Related]

  • 14. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.
    Gattis SG, Hernick M, Fierke CA.
    J Biol Chem; 2010 Oct 29; 285(44):33788-96. PubMed ID: 20709752
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
    Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR.
    Biochemistry; 2007 Mar 27; 46(12):3793-802. PubMed ID: 17335290
    [Abstract] [Full Text] [Related]

  • 16. Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
    Gennadios HA, Whittington DA, Li X, Fierke CA, Christianson DW.
    Biochemistry; 2006 Jul 04; 45(26):7940-8. PubMed ID: 16800620
    [Abstract] [Full Text] [Related]

  • 17. Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway.
    Hyland SA, Eveland SS, Anderson MS.
    J Bacteriol; 1997 Mar 04; 179(6):2029-37. PubMed ID: 9068651
    [Abstract] [Full Text] [Related]

  • 18. Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
    Whittington DA, Rusche KM, Shin H, Fierke CA, Christianson DW.
    Proc Natl Acad Sci U S A; 2003 Jul 08; 100(14):8146-50. PubMed ID: 12819349
    [Abstract] [Full Text] [Related]

  • 19. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.
    Kalinin DV, Holl R.
    Curr Top Med Chem; 2016 Jul 08; 16(21):2379-430. PubMed ID: 27072691
    [Abstract] [Full Text] [Related]

  • 20. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.
    Bioorg Med Chem Lett; 2013 Apr 15; 23(8):2362-7. PubMed ID: 23499237
    [Abstract] [Full Text] [Related]

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