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202 related items for PubMed ID: 11179214

  • 1. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain.
    Rossi D, Cozzio A, Flechsig E, Klein MA, Rülicke T, Aguzzi A, Weissmann C.
    EMBO J; 2001 Feb 15; 20(4):694-702. PubMed ID: 11179214
    [Abstract] [Full Text] [Related]

  • 2. Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.
    Flechsig E, Hegyi I, Leimeroth R, Zuniga A, Rossi D, Cozzio A, Schwarz P, Rülicke T, Götz J, Aguzzi A, Weissmann C.
    EMBO J; 2003 Jun 16; 22(12):3095-101. PubMed ID: 12805223
    [Abstract] [Full Text] [Related]

  • 3. Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
    Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heinrich C, Karunaratne A, Pasternak SH, Chishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D.
    J Mol Biol; 1999 Oct 01; 292(4):797-817. PubMed ID: 10525406
    [Abstract] [Full Text] [Related]

  • 4. Doppel-induced cerebellar degeneration in transgenic mice.
    Moore RC, Mastrangelo P, Bouzamondo E, Heinrich C, Legname G, Prusiner SB, Hood L, Westaway D, DeArmond SJ, Tremblay P.
    Proc Natl Acad Sci U S A; 2001 Dec 18; 98(26):15288-93. PubMed ID: 11734625
    [Abstract] [Full Text] [Related]

  • 5. Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein.
    Yamaguchi N, Sakaguchi S, Shigematsu K, Okimura N, Katamine S.
    Biochem Biophys Res Commun; 2004 Jul 09; 319(4):1247-52. PubMed ID: 15194501
    [Abstract] [Full Text] [Related]

  • 6. Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss.
    Silverman GL, Qin K, Moore RC, Yang Y, Mastrangelo P, Tremblay P, Prusiner SB, Cohen FE, Westaway D.
    J Biol Chem; 2000 Sep 01; 275(35):26834-41. PubMed ID: 10842180
    [Abstract] [Full Text] [Related]

  • 7. Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration.
    Li A, Sakaguchi S, Shigematsu K, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S.
    Am J Pathol; 2000 Nov 01; 157(5):1447-52. PubMed ID: 11073804
    [Abstract] [Full Text] [Related]

  • 8. BAX contributes to Doppel-induced apoptosis of prion-protein-deficient Purkinje cells.
    Heitz S, Lutz Y, Rodeau JL, Zanjani H, Gautheron V, Bombarde G, Richard F, Fuchs JP, Vogel MW, Mariani J, Bailly Y.
    Dev Neurobiol; 2007 Apr 01; 67(5):670-86. PubMed ID: 17443816
    [Abstract] [Full Text] [Related]

  • 9. Altered expression of type 1 inositol 1,4,5-trisphosphate receptor in the Ngsk Prnp deficient mice.
    Lee HP, Choi JK, Shin HY, Jeon YC, Jeong BH, Lee HG, Kim JI, Choi EK, Carp RI, Kim YS.
    Neuroscience; 2010 May 19; 167(3):799-808. PubMed ID: 20219645
    [Abstract] [Full Text] [Related]

  • 10. Tissue- and cell type-specific modification of prion protein (PrP)-like protein Doppel, which affects PrP endoproteolysis.
    Sakudo A, Onodera T.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):523-7. PubMed ID: 21144827
    [Abstract] [Full Text] [Related]

  • 11. Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.
    Sakaguchi S, Katamine S, Nishida N, Moriuchi R, Shigematsu K, Sugimoto T, Nakatani A, Kataoka Y, Houtani T, Shirabe S, Okada H, Hasegawa S, Miyamoto T, Noda T.
    Nature; 1996 Apr 11; 380(6574):528-31. PubMed ID: 8606772
    [Abstract] [Full Text] [Related]

  • 12. Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment.
    Anderson L, Rossi D, Linehan J, Brandner S, Weissmann C.
    Proc Natl Acad Sci U S A; 2004 Mar 09; 101(10):3644-9. PubMed ID: 15007176
    [Abstract] [Full Text] [Related]

  • 13. Polymorphisms within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders.
    Schröder B, Franz B, Hempfling P, Selbert M, Jürgens T, Kretzschmar HA, Bodemer M, Poser S, Zerr I.
    Hum Genet; 2001 Sep 09; 109(3):319-25. PubMed ID: 11702213
    [Abstract] [Full Text] [Related]

  • 14. BCL-2 counteracts Doppel-induced apoptosis of prion-protein-deficient Purkinje cells in the Ngsk Prnp(0/0) mouse.
    Heitz S, Gautheron V, Lutz Y, Rodeau JL, Zanjani HS, Sugihara I, Bombarde G, Richard F, Fuchs JP, Vogel MW, Mariani J, Bailly Y.
    Dev Neurobiol; 2008 Feb 15; 68(3):332-48. PubMed ID: 18085563
    [Abstract] [Full Text] [Related]

  • 15. Cell-autonomous PrP-Doppel interaction regulates apoptosis in PrP gene-deficient neuronal cells.
    Sakudo A, Lee DC, Nakamura I, Taniuchi Y, Saeki K, Matsumoto Y, Itohara S, Ikuta K, Onodera T.
    Biochem Biophys Res Commun; 2005 Jul 29; 333(2):448-54. PubMed ID: 15950943
    [Abstract] [Full Text] [Related]

  • 16. Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration.
    Atarashi R, Nishida N, Shigematsu K, Goto S, Kondo T, Sakaguchi S, Katamine S.
    J Biol Chem; 2003 Aug 01; 278(31):28944-9. PubMed ID: 12759361
    [Abstract] [Full Text] [Related]

  • 17. Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease.
    Tuzi NL, Gall E, Melton D, Manson JC.
    J Gen Virol; 2002 Mar 01; 83(Pt 3):705-711. PubMed ID: 11842265
    [Abstract] [Full Text] [Related]

  • 18. Purkinje-cell degeneration in prion protein-deficient mice is associated with a cerebellum-specific Doppel protein species signature.
    Al Bersaoui R, Robert I, Lutz Y, Blanc F, Sommermeyer-Leroux G, Shibaguchi H, Aunis D, Fuchs JP.
    FEBS Lett; 2005 May 09; 579(12):2715-21. PubMed ID: 15862314
    [Abstract] [Full Text] [Related]

  • 19. Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene.
    Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Shigematsu K.
    Cell Mol Neurobiol; 2000 Oct 09; 20(5):553-67. PubMed ID: 10930132
    [Abstract] [Full Text] [Related]

  • 20. Abnormal activation of glial cells in the brains of prion protein-deficient mice ectopically expressing prion protein-like protein, PrPLP/Dpl.
    Atarashi R, Sakaguchi S, Shigematsu K, Arima K, Okimura N, Yamaguchi N, Li A, Kopacek J, Katamine S.
    Mol Med; 2001 Dec 09; 7(12):803-9. PubMed ID: 11844868
    [Abstract] [Full Text] [Related]

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