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Journal Abstract Search

194 related items for PubMed ID: 11179458

  • 1. Characterization of recombinant, soluble beta-secretase from an insect cell expression system.
    Mallender WD, Yager D, Onstead L, Nichols MR, Eckman C, Sambamurti K, Kopcho LM, Marcinkeviciene J, Copeland RA, Rosenberry TL.
    Mol Pharmacol; 2001 Mar; 59(3):619-26. PubMed ID: 11179458
    [Abstract] [Full Text] [Related]

  • 2. Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles.
    Hook VY, Toneff T, Aaron W, Yasothornsrikul S, Bundey R, Reisine T.
    J Neurochem; 2002 Apr; 81(2):237-56. PubMed ID: 12064471
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  • 3. Recombinant insect cell expression and purification of human beta-secretase (BACE-1) for X-ray crystallography.
    Bruinzeel W, Yon J, Giovannelli S, Masure S.
    Protein Expr Purif; 2002 Oct; 26(1):139-48. PubMed ID: 12356481
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  • 4. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.
    Science; 1999 Oct 22; 286(5440):735-41. PubMed ID: 10531052
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  • 5. Modeling of substrate specificity of the Alzheimer's disease amyloid precursor protein beta-secretase.
    Sauder JM, Arthur JW, Dunbrack RL.
    J Mol Biol; 2000 Jul 07; 300(2):241-8. PubMed ID: 10873463
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  • 7. Expression, purification and activity measurement of soluble BACE protein in E.coli.
    Wei XC, Li H, Ji JG, Li R, Ren YF, Feng JH, Hao FY.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai); 2002 Jul 07; 34(4):498-501. PubMed ID: 12098775
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  • 9. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
    Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L.
    Hum Mol Genet; 2001 Jun 01; 10(12):1317-24. PubMed ID: 11406613
    [Abstract] [Full Text] [Related]

  • 10. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
    Boddapati S, Levites Y, Sierks MR.
    J Mol Biol; 2011 Jan 14; 405(2):436-47. PubMed ID: 21073877
    [Abstract] [Full Text] [Related]

  • 11. Biochemical and cell-based assays for characterization of BACE-1 inhibitors.
    Pietrak BL, Crouthamel MC, Tugusheva K, Lineberger JE, Xu M, DiMuzio JM, Steele T, Espeseth AS, Stachel SJ, Coburn CA, Graham SL, Vacca JP, Shi XP, Simon AJ, Hazuda DJ, Lai MT.
    Anal Biochem; 2005 Jul 01; 342(1):144-51. PubMed ID: 15958191
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  • 13. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S, Refolo LM, Sambamurti K.
    J Mol Neurosci; 2004 Jul 01; 24(1):137-43. PubMed ID: 15314262
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  • 14. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.
    Nature; 1999 Dec 02; 402(6761):533-7. PubMed ID: 10591213
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  • 18. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression.
    Liu K, Doms RW, Lee VM.
    Biochemistry; 2002 Mar 05; 41(9):3128-36. PubMed ID: 11863452
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  • 19. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 05; 100(3):802-9. PubMed ID: 17156133
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  • 20. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase.
    Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R.
    J Biol Chem; 2000 Dec 01; 275(48):37712-7. PubMed ID: 10956649
    [Abstract] [Full Text] [Related]

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