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Journal Abstract Search

194 related items for PubMed ID: 11179458

  • 21. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
    Hook VY, Reisine TD.
    J Neurosci Res; 2003 Nov 01; 74(3):393-405. PubMed ID: 14598316
    [Abstract] [Full Text] [Related]

  • 22. Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.
    Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA.
    Arch Biochem Biophys; 2003 Feb 15; 410(2):307-16. PubMed ID: 12573291
    [Abstract] [Full Text] [Related]

  • 23. Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.
    Emmons TL, Mildner AM, Lull JM, Leone JW, Fischer HD, Heinrikson RL, Tomasselli AG.
    Protein Pept Lett; 2009 Feb 15; 16(2):121-31. PubMed ID: 19200034
    [Abstract] [Full Text] [Related]

  • 24. Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0.
    Saric A, Brügge Lz, Müller-Pompalla D, Rysiok T, Ousson S, Permanne B, Quattropani A, Busch M, Beher D, Hussain I.
    J Biomol Screen; 2013 Mar 15; 18(3):277-85. PubMed ID: 23023105
    [Abstract] [Full Text] [Related]

  • 25. Design and synthesis of novel 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridines as small molecule BACE-1 inhibitors.
    Razzaghi-Asl N, Firuzi O, Hemmateenejad B, Javidnia K, Edraki N, Miri R.
    Bioorg Med Chem; 2013 Nov 15; 21(22):6893-909. PubMed ID: 24113238
    [Abstract] [Full Text] [Related]

  • 26. Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
    Fukumoto H, Cheung BS, Hyman BT, Irizarry MC.
    Arch Neurol; 2002 Sep 15; 59(9):1381-9. PubMed ID: 12223024
    [Abstract] [Full Text] [Related]

  • 27. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
    Vassar R.
    J Mol Neurosci; 2001 Oct 15; 17(2):157-70. PubMed ID: 11816789
    [Abstract] [Full Text] [Related]

  • 28. Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity.
    Scholz D, Chernyshova Y, Ückert AK, Leist M.
    J Neurochem; 2018 Oct 15; 147(2):256-274. PubMed ID: 29804308
    [Abstract] [Full Text] [Related]

  • 29. ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
    Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G.
    Mol Cell Neurosci; 2000 Nov 15; 16(5):609-19. PubMed ID: 11083922
    [Abstract] [Full Text] [Related]

  • 30. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 15; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 31. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y.
    Eur J Pharmacol; 2009 Nov 25; 623(1-3):14-21. PubMed ID: 19765582
    [Abstract] [Full Text] [Related]

  • 32. Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?
    Nawrot B.
    Acta Biochim Pol; 2004 Nov 25; 51(2):431-44. PubMed ID: 15218540
    [Abstract] [Full Text] [Related]

  • 33. Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties.
    Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M.
    J Biol Chem; 2000 Jul 14; 275(28):21099-106. PubMed ID: 10887202
    [Abstract] [Full Text] [Related]

  • 34. Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review.
    Gehlot P, Kumar S, Kumar Vyas V, Singh Choudhary B, Sharma M, Malik R.
    Bioorg Med Chem; 2022 Nov 15; 74():117047. PubMed ID: 36265268
    [Abstract] [Full Text] [Related]

  • 35. Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.
    Arbel M, Yacoby I, Solomon B.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7718-23. PubMed ID: 15894613
    [Abstract] [Full Text] [Related]

  • 36. Inhibition of BACE, a promising approach to Alzheimer's disease therapy.
    Roggo S.
    Curr Top Med Chem; 2002 Apr 24; 2(4):359-70. PubMed ID: 11966460
    [Abstract] [Full Text] [Related]

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