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180 related items for PubMed ID: 11196153

  • 1. Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine.
    Wouters BG, Delahoussaye YM, Evans JW, Birrell GW, Dorie MJ, Wang J, MacDermed D, Chiu RK, Brown JM.
    Cancer Res; 2001 Jan 01; 61(1):145-52. PubMed ID: 11196153
    [Abstract] [Full Text] [Related]

  • 2. Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.
    Yang B, Reynolds CP.
    Clin Cancer Res; 2005 Apr 01; 11(7):2774-80. PubMed ID: 15814660
    [Abstract] [Full Text] [Related]

  • 3. Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.
    Yang B, Keshelava N, Anderson CP, Reynolds CP.
    Cancer Res; 2003 Apr 01; 63(7):1520-6. PubMed ID: 12670899
    [Abstract] [Full Text] [Related]

  • 4. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
    Elwell JH, Siim BG, Evans JW, Brown JM.
    Biochem Pharmacol; 1997 Jul 15; 54(2):249-57. PubMed ID: 9271329
    [Abstract] [Full Text] [Related]

  • 5. Relationships between the mitochondrial permeability transition and oxidative stress during ara-C toxicity.
    Backway KL, McCulloch EA, Chow S, Hedley DW.
    Cancer Res; 1997 Jun 15; 57(12):2446-51. PubMed ID: 9192824
    [Abstract] [Full Text] [Related]

  • 6. DNA repair mechanisms are involved in the hypoxia-dependent toxicity of NLCQ-1 (NSC 709257) and its synergistic interaction with alkylating agents.
    Papadopoulou MV, Bloomer WD.
    In Vivo; 2007 Jun 15; 21(2):175-80. PubMed ID: 17436565
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of DNA replication by tirapazamine.
    Peters KB, Wang H, Brown JM, Iliakis G.
    Cancer Res; 2001 Jul 15; 61(14):5425-31. PubMed ID: 11454687
    [Abstract] [Full Text] [Related]

  • 9. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
    Hay MP, Pruijn FB, Gamage SA, Liyanage HD, Kovacs MS, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2004 Jan 15; 47(2):475-88. PubMed ID: 14711317
    [Abstract] [Full Text] [Related]

  • 10. Tirapazamine is metabolized to its DNA-damaging radical by intranuclear enzymes.
    Evans JW, Yudoh K, Delahoussaye YM, Brown JM.
    Cancer Res; 1998 May 15; 58(10):2098-101. PubMed ID: 9605751
    [Abstract] [Full Text] [Related]

  • 11. Estradiol attenuates mitochondrial depolarization in polyol-stressed lens epithelial cells.
    Flynn JM, Cammarata PR.
    Mol Vis; 2006 Apr 04; 12():271-82. PubMed ID: 16617294
    [Abstract] [Full Text] [Related]

  • 12. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
    Siim BG, Menke DR, Dorie MJ, Brown JM.
    Cancer Res; 1997 Jul 15; 57(14):2922-8. PubMed ID: 9230202
    [Abstract] [Full Text] [Related]

  • 13. 4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: comparison with tirapazamine.
    Papadopoulou MV, Ji M, Rao MK, Bloomer WD.
    Oncol Res; 2001 Jul 15; 12(8):325-33. PubMed ID: 11589303
    [Abstract] [Full Text] [Related]

  • 14. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
    Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, Wilson WR.
    Cancer Res; 2004 Jan 15; 64(2):736-42. PubMed ID: 14744792
    [Abstract] [Full Text] [Related]

  • 15. [TFAR19 enhances the opening of permeability transition pore in the mitochondrial membrane of mice liver].
    Tian HK, Xia T, Jiang CS, Zhang HM, Wang K, Li XJ.
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai); 2002 May 15; 34(3):279-84. PubMed ID: 12019438
    [Abstract] [Full Text] [Related]

  • 16. Mitochondrial superoxide plays a crucial role in the development of mitochondrial dysfunction during high glucose exposure in rat renal proximal tubular cells.
    Munusamy S, MacMillan-Crow LA.
    Free Radic Biol Med; 2009 Apr 15; 46(8):1149-57. PubMed ID: 19439219
    [Abstract] [Full Text] [Related]

  • 17. The usefulness of continuous administration of hypoxic cytotoxin combined with mild temperature hyperthermia, with reference to effects on quiescent tumour cell populations.
    Masunaga S, Nagasawa H, Uto Y, Hori H, Suzuki M, Nagata K, Kinashi Y, Ono K.
    Int J Hyperthermia; 2005 Jun 15; 21(4):305-18. PubMed ID: 16019857
    [Abstract] [Full Text] [Related]

  • 18. Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes.
    Tjalkens RB, Phelka AD, Philbert MA.
    Neurotoxicology; 2003 Jun 15; 24(3):391-401. PubMed ID: 12782104
    [Abstract] [Full Text] [Related]

  • 19. Methods to measure membrane potential and permeability transition in the mitochondria during apoptosis.
    Zamzami N, Kroemer G.
    Methods Mol Biol; 2004 Jun 15; 282():103-15. PubMed ID: 15105559
    [Abstract] [Full Text] [Related]

  • 20. Tirapazamine: hypoxic cytotoxicity and interaction with radiation as assessed by the micronucleus assay.
    Shibata T, Shibamoto Y, Sasai K, Oya N, Murata R, Takagi T, Hiraoka M, Takahashi M, Abe M.
    Br J Cancer Suppl; 1996 Jul 15; 27():S61-4. PubMed ID: 8763848
    [Abstract] [Full Text] [Related]


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