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162 related items for PubMed ID: 11234887

  • 1. Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells.
    Harvey S, Decker R, Dai Y, Schaefer G, Tang L, Kramer L, Dent P, Grant S.
    Clin Cancer Res; 2001 Feb; 7(2):320-30. PubMed ID: 11234887
    [Abstract] [Full Text] [Related]

  • 2. Potentiation of 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01).
    Tang L, Boise LH, Dent P, Grant S.
    Biochem Pharmacol; 2000 Nov 15; 60(10):1445-56. PubMed ID: 11020446
    [Abstract] [Full Text] [Related]

  • 3. 7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.
    Cartee L, Sankala H, Davis C, Smith R, Maggio S, Lin PS, Dent P, Grant S.
    Int J Oncol; 2002 Aug 15; 21(2):351-9. PubMed ID: 12118331
    [Abstract] [Full Text] [Related]

  • 4. Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.
    Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S.
    Mol Pharmacol; 1997 Dec 15; 52(6):1000-9. PubMed ID: 9396780
    [Abstract] [Full Text] [Related]

  • 5. Bryostatin 1 and UCN-01 potentiate 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms.
    Wang S, Wang Z, Grant S.
    Mol Pharmacol; 2003 Jan 15; 63(1):232-42. PubMed ID: 12488556
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells.
    Dai Y, Yu C, Singh V, Tang L, Wang Z, McInistry R, Dent P, Grant S.
    Cancer Res; 2001 Jul 01; 61(13):5106-15. PubMed ID: 11431348
    [Abstract] [Full Text] [Related]

  • 7. Modulation of 1-[beta-D-arabinofuranosyl] cytosine-induced apoptosis in human myeloid leukemia cells by staurosporine and other pharmacological inhibitors of protein kinase C.
    Grant S, Turner AJ, Bartimole TM, Nelms PA, Joe VC, Jarvis WD.
    Oncol Res; 1994 Jul 01; 6(2):87-99. PubMed ID: 7949469
    [Abstract] [Full Text] [Related]

  • 8. Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.
    Wang Z, Van Tuyle G, Conrad D, Fisher PB, Dent P, Grant S.
    Cancer Res; 1999 Mar 15; 59(6):1259-67. PubMed ID: 10096557
    [Abstract] [Full Text] [Related]

  • 9. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) promotes mitochondrial dysfunction and apoptosis induced by 7-hydroxystaurosporine and mitogen-activated protein kinase kinase inhibitors in human leukemia cells that ectopically express Bcl-2 and Bcl-xL.
    Dai Y, Dent P, Grant S.
    Mol Pharmacol; 2003 Dec 15; 64(6):1402-9. PubMed ID: 14645670
    [Abstract] [Full Text] [Related]

  • 10. Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L).
    Wang Z, Wang S, Dai Y, Grant S.
    J Pharmacol Exp Ther; 2002 May 15; 301(2):568-77. PubMed ID: 11961058
    [Abstract] [Full Text] [Related]

  • 11. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
    Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S.
    Cancer Res; 2001 Mar 15; 61(6):2583-91. PubMed ID: 11289135
    [Abstract] [Full Text] [Related]

  • 12. Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
    Almenara J, Rosato R, Grant S.
    Leukemia; 2002 Jul 15; 16(7):1331-43. PubMed ID: 12094258
    [Abstract] [Full Text] [Related]

  • 13. The role of c-Jun kinase in the apoptotic response to nucleoside analogue-induced DNA damage.
    Sampath D, Plunkett W.
    Cancer Res; 2000 Nov 15; 60(22):6408-15. PubMed ID: 11103806
    [Abstract] [Full Text] [Related]

  • 14. Potentiation of the activity of 1-beta-D-arabinofuranosylcytosine by the protein kinase C activator bryostatin 1 in HL-60 cells: association with enhanced fragmentation of mature DNA.
    Grant S, Jarvis WD, Swerdlow PS, Turner AJ, Traylor RS, Wallace HJ, Lin PS, Pettit GR, Gewirtz DA.
    Cancer Res; 1992 Nov 15; 52(22):6270-8. PubMed ID: 1423273
    [Abstract] [Full Text] [Related]

  • 15. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53.
    Shao RG, Shimizu T, Pommier Y.
    Exp Cell Res; 1997 Aug 01; 234(2):388-97. PubMed ID: 9260909
    [Abstract] [Full Text] [Related]

  • 16. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
    Rosato RR, Almenara JA, Grant S.
    Cancer Res; 2003 Jul 01; 63(13):3637-45. PubMed ID: 12839953
    [Abstract] [Full Text] [Related]

  • 17. The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells.
    Pei XY, Dai Y, Rahmani M, Li W, Dent P, Grant S.
    Clin Cancer Res; 2005 Jun 15; 11(12):4589-600. PubMed ID: 15958645
    [Abstract] [Full Text] [Related]

  • 18. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.
    Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C, Dent P, Grant S.
    Blood; 2005 Feb 15; 105(4):1706-16. PubMed ID: 15494423
    [Abstract] [Full Text] [Related]

  • 19. "Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis.
    Fang G, Chang BS, Kim CN, Perkins C, Thompson CB, Bhalla KN.
    Cancer Res; 1998 Aug 01; 58(15):3202-8. PubMed ID: 9699642
    [Abstract] [Full Text] [Related]

  • 20. Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
    Jia W, Yu C, Rahmani M, Krystal G, Sausville EA, Dent P, Grant S.
    Blood; 2003 Sep 01; 102(5):1824-32. PubMed ID: 12738674
    [Abstract] [Full Text] [Related]

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