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162 related items for PubMed ID: 11237337

  • 1. A fluorescence-based homogeneous assay for measuring activity of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase.
    Wang W, Maniar M, Jain R, Jacobs J, Trias J, Yuan Z.
    Anal Biochem; 2001 Mar; 290(2):338-46. PubMed ID: 11237337
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  • 4. Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway.
    McClerren AL, Zhou P, Guan Z, Raetz CR, Rudolph J.
    Biochemistry; 2005 Feb 01; 44(4):1106-13. PubMed ID: 15667204
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  • 5. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
    Jackman JE, Raetz CR, Fierke CA.
    Biochemistry; 1999 Feb 09; 38(6):1902-11. PubMed ID: 10026271
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  • 7. UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
    Hernick M, Gennadios HA, Whittington DA, Rusche KM, Christianson DW, Fierke CA.
    J Biol Chem; 2005 Apr 29; 280(17):16969-78. PubMed ID: 15705580
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  • 8. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466.
    Cuny GD.
    Expert Opin Ther Pat; 2009 Jun 29; 19(6):893-9. PubMed ID: 19473108
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  • 9. Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli.
    Barb AW, McClerren AL, Snehelatha K, Reynolds CM, Zhou P, Raetz CR.
    Biochemistry; 2007 Mar 27; 46(12):3793-802. PubMed ID: 17335290
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  • 10. Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.
    Hernick M, Fierke CA.
    Biochemistry; 2006 Dec 26; 45(51):15240-8. PubMed ID: 17176046
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  • 11. Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine.
    Anderson MS, Robertson AD, Macher I, Raetz CR.
    Biochemistry; 1988 Mar 22; 27(6):1908-17. PubMed ID: 3288280
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  • 12. A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA).
    Shapiro AB, Ross PL, Gao N, Livchak S, Kern G, Yang W, Andrews B, Thresher J.
    J Biomol Screen; 2013 Mar 22; 18(3):341-7. PubMed ID: 23015018
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  • 13. Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli.
    Gehring AM, Lees WJ, Mindiola DJ, Walsh CT, Brown ED.
    Biochemistry; 1996 Jan 16; 35(2):579-85. PubMed ID: 8555230
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  • 14. Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP-N-acetylglucosamine to UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine.
    Anderson MS, Raetz CR.
    J Biol Chem; 1987 Apr 15; 262(11):5159-69. PubMed ID: 3549716
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  • 16. Active site metal ion in UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) switches between Fe(II) and Zn(II) depending on cellular conditions.
    Gattis SG, Hernick M, Fierke CA.
    J Biol Chem; 2010 Oct 29; 285(44):33788-96. PubMed ID: 20709752
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  • 17. Structure of the bacterial deacetylase LpxC bound to the nucleotide reaction product reveals mechanisms of oxyanion stabilization and proton transfer.
    Clayton GM, Klein DJ, Rickert KW, Patel SB, Kornienko M, Zugay-Murphy J, Reid JC, Tummala S, Sharma S, Singh SB, Miesel L, Lumb KJ, Soisson SM.
    J Biol Chem; 2013 Nov 22; 288(47):34073-34080. PubMed ID: 24108127
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  • 18. A fluorescence-based assay for measuring N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase activity.
    Huang X, Hernick M.
    Anal Biochem; 2011 Jul 15; 414(2):278-81. PubMed ID: 21477577
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  • 19. Exploring the UDP pocket of LpxC through amino acid analogs.
    Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.
    Bioorg Med Chem Lett; 2013 Apr 15; 23(8):2362-7. PubMed ID: 23499237
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  • 20. Design and synthesis of potent Gram-negative specific LpxC inhibitors.
    Mansoor UF, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Siddiqui MA.
    Bioorg Med Chem Lett; 2011 Feb 15; 21(4):1155-61. PubMed ID: 21273067
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