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281 related items for PubMed ID: 11238126

  • 1. Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling.
    Morgan MA, Dolp O, Reuter CW.
    Blood; 2001 Mar 15; 97(6):1823-34. PubMed ID: 11238126
    [Abstract] [Full Text] [Related]

  • 2. Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines.
    Miranda MB, McGuire TF, Johnson DE.
    Leukemia; 2002 Apr 15; 16(4):683-92. PubMed ID: 11960350
    [Abstract] [Full Text] [Related]

  • 3. Pharmacologic mitogen-activated protein/extracellular signal-regulated kinase kinase/mitogen-activated protein kinase inhibitors interact synergistically with STI571 to induce apoptosis in Bcr/Abl-expressing human leukemia cells.
    Yu C, Krystal G, Varticovksi L, McKinstry R, Rahmani M, Dent P, Grant S.
    Cancer Res; 2002 Jan 01; 62(1):188-99. PubMed ID: 11782377
    [Abstract] [Full Text] [Related]

  • 4. Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion.
    Clark SS, Zhong L, Filiault D, Perman S, Ren Z, Gould M, Yang X.
    Clin Cancer Res; 2003 Oct 01; 9(12):4494-504. PubMed ID: 14555523
    [Abstract] [Full Text] [Related]

  • 5. Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors.
    Zhang J, Lodish HF.
    Blood; 2004 Sep 15; 104(6):1679-87. PubMed ID: 15166036
    [Abstract] [Full Text] [Related]

  • 6. Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery.
    Okano J, Rustgi AK.
    J Biol Chem; 2001 Jun 01; 276(22):19555-64. PubMed ID: 11278851
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells.
    Stadheim TA, Xiao H, Eastman A.
    Cancer Res; 2001 Feb 15; 61(4):1533-40. PubMed ID: 11245462
    [Abstract] [Full Text] [Related]

  • 8. Coadministration of UCN-01 with MEK1/2 inhibitors potently induces apoptosis in BCR/ABL+ leukemia cells sensitive and resistant to ST1571.
    Yu C, Dai Y, Dent P, Grant S.
    Cancer Biol Ther; 2002 Feb 15; 1(6):674-82. PubMed ID: 12642693
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
    Brassard DL, English JM, Malkowski M, Kirschmeier P, Nagabhushan TL, Bishop WR.
    Exp Cell Res; 2002 Feb 15; 273(2):138-46. PubMed ID: 11822869
    [Abstract] [Full Text] [Related]

  • 10. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.
    Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE.
    Oncogene; 2002 Nov 21; 21(53):8075-88. PubMed ID: 12444544
    [Abstract] [Full Text] [Related]

  • 11. The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrine-paracrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway.
    Park JI, Strock CJ, Ball DW, Nelkin BD.
    Mol Cell Biol; 2003 Jan 21; 23(2):543-54. PubMed ID: 12509453
    [Abstract] [Full Text] [Related]

  • 12. Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism.
    Dai Y, Landowski TH, Rosen ST, Dent P, Grant S.
    Blood; 2002 Nov 01; 100(9):3333-43. PubMed ID: 12384435
    [Abstract] [Full Text] [Related]

  • 13. Induction of apoptosis in BCR/ABL+ cells by histone deacetylase inhibitors involves reciprocal effects on the RAF/MEK/ERK and JNK pathways.
    Yu C, Subler M, Rahmani M, Reese E, Krystal G, Conrad D, Dent P, Grant S.
    Cancer Biol Ther; 2003 Nov 01; 2(5):544-51. PubMed ID: 14614324
    [Abstract] [Full Text] [Related]

  • 14. Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.
    Blalock WL, Navolanic PM, Steelman LS, Shelton JG, Moye PW, Lee JT, Franklin RA, Mirza A, McMahon M, White MK, McCubrey JA.
    Leukemia; 2003 Jun 01; 17(6):1058-67. PubMed ID: 12764369
    [Abstract] [Full Text] [Related]

  • 15. The 96 kDa protein kinase activated by oncogenic Ras in Xenopus egg extracts is also activated by constitutively active Mek: activation requires serine/threonine phosphorylation.
    Pan BT, Zhang Y, Brott B, Chen DH.
    Oncogene; 1997 Apr 10; 14(14):1653-60. PubMed ID: 9135066
    [Abstract] [Full Text] [Related]

  • 16. Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways.
    Kamiguti AS, Harris RJ, Slupsky JR, Baker PK, Cawley JC, Zuzel M.
    Oncogene; 2003 Apr 17; 22(15):2272-84. PubMed ID: 12700663
    [Abstract] [Full Text] [Related]

  • 17. Activation of Raf-1/MEK-1/2/p42/44(MAPK) cascade alone is sufficient to uncouple LDL receptor expression from cell growth.
    Kapoor GS, Atkins BA, Mehta KD.
    Mol Cell Biochem; 2002 Jul 17; 236(1-2):13-22. PubMed ID: 12190111
    [Abstract] [Full Text] [Related]

  • 18. Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
    Plattner R, Gupta S, Khosravi-Far R, Sato KY, Perucho M, Der CJ, Stanbridge EJ.
    Oncogene; 1999 Mar 11; 18(10):1807-17. PubMed ID: 10086335
    [Abstract] [Full Text] [Related]

  • 19. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.
    Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N.
    Blood; 2001 Sep 01; 98(5):1429-39. PubMed ID: 11520792
    [Abstract] [Full Text] [Related]

  • 20. Importance of MEK in neutrophil microbicidal responsiveness.
    Downey GP, Butler JR, Tapper H, Fialkow L, Saltiel AR, Rubin BB, Grinstein S.
    J Immunol; 1998 Jan 01; 160(1):434-43. PubMed ID: 9552001
    [Abstract] [Full Text] [Related]

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