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Journal Abstract Search

393 related items for PubMed ID: 11278930

  • 1. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.
    Chuang YJ, Swanson R, Raja SM, Olson ST.
    J Biol Chem; 2001 May 04; 276(18):14961-71. PubMed ID: 11278930
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  • 5. Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements: consequences for the mechanism of factor Xa inhibition by antithrombin-heparin complexes.
    Futamura A, Beechem JM, Gettins PG.
    Biochemistry; 2001 Jun 05; 40(22):6680-7. PubMed ID: 11380263
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  • 6. Calcium enhances heparin catalysis of the antithrombin-factor Xa reaction by promoting the assembly of an intermediate heparin-antithrombin-factor Xa bridging complex. Demonstration by rapid kinetics studies.
    Rezaie AR, Olson ST.
    Biochemistry; 2000 Oct 03; 39(39):12083-90. PubMed ID: 11009624
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  • 7. Conformational activation of antithrombin by heparin involves an altered exosite interaction with protease.
    Izaguirre G, Aguila S, Qi L, Swanson R, Roth R, Rezaie AR, Gettins PG, Olson ST.
    J Biol Chem; 2014 Dec 05; 289(49):34049-64. PubMed ID: 25331949
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  • 9. Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.
    Olson ST, Richard B, Izaguirre G, Schedin-Weiss S, Gettins PG.
    Biochimie; 2010 Nov 05; 92(11):1587-96. PubMed ID: 20685328
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  • 10. Probing the molecular basis of factor Xa specificity by mutagenesis of the serpin, antithrombin.
    Rezaie AR, Yang L.
    Biochim Biophys Acta; 2001 Oct 03; 1528(2-3):167-76. PubMed ID: 11687304
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  • 14. Dissociation of heparin-dependent thrombin and factor Xa inhibitory activities of antithrombin-III by mutations in the reactive site.
    Theunissen HJ, Dijkema R, Grootenhuis PD, Swinkels JC, de Poorter TL, Carati P, Visser A.
    J Biol Chem; 1993 Apr 25; 268(12):9035-40. PubMed ID: 8473344
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  • 15. Heparin activates antithrombin anticoagulant function by generating new interaction sites (exosites) for blood clotting proteinases.
    Olson ST, Chuang YJ.
    Trends Cardiovasc Med; 2002 Nov 25; 12(8):331-8. PubMed ID: 12536119
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  • 16. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement.
    Olson ST, Björk I, Sheffer R, Craig PA, Shore JD, Choay J.
    J Biol Chem; 1992 Jun 25; 267(18):12528-38. PubMed ID: 1618758
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  • 20. Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis.
    Raja SM, Chhablani N, Swanson R, Thompson E, Laffan M, Lane DA, Olson ST.
    J Biol Chem; 2003 Apr 18; 278(16):13688-95. PubMed ID: 12591924
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