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Journal Abstract Search

230 related items for PubMed ID: 11284680

  • 1. Interligand Overhauser effects in type II dihydrofolate reductase.
    Li D, Levy LA, Gabel SA, Lebetkin MS, DeRose EF, Wall MJ, Howell EE, London RE.
    Biochemistry; 2001 Apr 10; 40(14):4242-52. PubMed ID: 11284680
    [Abstract] [Full Text] [Related]

  • 2. A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition.
    Park H, Bradrick TD, Howell EE.
    Protein Eng; 1997 Dec 10; 10(12):1415-24. PubMed ID: 9543003
    [Abstract] [Full Text] [Related]

  • 3. Unusual binding stoichiometries and cooperativity are observed during binary and ternary complex formation in the single active pore of R67 dihydrofolate reductase, a D2 symmetric protein.
    Bradrick TD, Beechem JM, Howell EE.
    Biochemistry; 1996 Sep 03; 35(35):11414-24. PubMed ID: 8784197
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  • 5. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.
    Howell EE, Shukla U, Hicks SN, Smiley RD, Kuhn LA, Zavodszky MI.
    J Comput Aided Mol Des; 2001 Nov 03; 15(11):1035-52. PubMed ID: 11989624
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  • 6. Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
    Hicks SN, Smiley RD, Hamilton JB, Howell EE.
    Biochemistry; 2003 Sep 16; 42(36):10569-78. PubMed ID: 12962480
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  • 7. Structure of the Q67H mutant of R67 dihydrofolate reductase-NADP+ complex reveals a novel cofactor binding mode.
    Divya N, Grifith E, Narayana N.
    Protein Sci; 2007 Jun 16; 16(6):1063-8. PubMed ID: 17473013
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  • 10. Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
    Jackson M, Chopra S, Smiley RD, Maynord PO, Rosowsky A, London RE, Levy L, Kalman TI, Howell EE.
    Biochemistry; 2005 Sep 20; 44(37):12420-33. PubMed ID: 16156655
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  • 11. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+.
    Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF.
    Biochemistry; 1999 Apr 06; 38(14):4303-12. PubMed ID: 10194348
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  • 12. A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.
    Chopra S, Dooling RM, Horner CG, Howell EE.
    J Biol Chem; 2008 Feb 22; 283(8):4690-8. PubMed ID: 18086667
    [Abstract] [Full Text] [Related]

  • 13. Vibrational structure of dihydrofolate bound to R67 dihydrofolate reductase.
    Deng H, Callender R, Howell E.
    J Biol Chem; 2001 Dec 28; 276(52):48956-60. PubMed ID: 11679579
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  • 15. NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity.
    Pitcher WH, DeRose EF, Mueller GA, Howell EE, London RE.
    Biochemistry; 2003 Sep 30; 42(38):11150-60. PubMed ID: 14503865
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  • 17. Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase.
    Schnell JR, Dyson HJ, Wright PE.
    Biochemistry; 2004 Jan 20; 43(2):374-83. PubMed ID: 14717591
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  • 18. Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes.
    Osborne MJ, Venkitakrishnan RP, Dyson HJ, Wright PE.
    Protein Sci; 2003 Oct 20; 12(10):2230-8. PubMed ID: 14500880
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  • 19. Conformation of NADP+ bound to a type II dihydrofolate reductase.
    Brito RM, Rudolph FB, Rosevear PR.
    Biochemistry; 1991 Feb 12; 30(6):1461-9. PubMed ID: 1993165
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  • 20. Mechanistic studies of R67 dihydrofolate reductase. Effects of pH and an H62C mutation.
    Park H, Zhuang P, Nichols R, Howell EE.
    J Biol Chem; 1997 Jan 24; 272(4):2252-8. PubMed ID: 8999931
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