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102 related items for PubMed ID: 11292064

  • 1. Toxic effect of troglitazone on cultured rat hepatocytes.
    Toyoda Y, Tsuchida A, Iwami E, Miwa I.
    Life Sci; 2001 Mar 09; 68(16):1867-76. PubMed ID: 11292064
    [Abstract] [Full Text] [Related]

  • 2. Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data.
    Kostrubsky VE, Rahbari R, Lodola A, Davies T.
    Toxicol Sci; 2003 Feb 09; 71(2):282; author reply 282-4. PubMed ID: 12563115
    [No Abstract] [Full Text] [Related]

  • 3. Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells.
    Yamamoto Y, Nakajima M, Yamazaki H, Yokoi T.
    Life Sci; 2001 Dec 14; 70(4):471-82. PubMed ID: 11798015
    [Abstract] [Full Text] [Related]

  • 4. Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors.
    Lloyd S, Hayden MJ, Sakai Y, Fackett A, Silber PM, Hewitt NJ, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):57-71. PubMed ID: 12399155
    [Abstract] [Full Text] [Related]

  • 5. Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes.
    Lauer B, Tuschl G, Kling M, Mueller SO.
    Chem Biol Interact; 2009 Apr 15; 179(1):17-24. PubMed ID: 19022234
    [Abstract] [Full Text] [Related]

  • 6. Correlation between troglitazone cytotoxicity and drug metabolic enzyme activities in cryopreserved human hepatocytes.
    Hewitt NJ, Lloyd S, Hayden M, Butler R, Sakai Y, Springer R, Fackett A, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):73-82. PubMed ID: 12399156
    [Abstract] [Full Text] [Related]

  • 7. The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes.
    Lim PL, Liu J, Go ML, Boelsterli UA.
    Toxicol Sci; 2008 Feb 10; 101(2):341-9. PubMed ID: 17975114
    [Abstract] [Full Text] [Related]

  • 8. Species-specific toxicity of troglitazone on rats and human by gel entrapped hepatocytes.
    Shen C, Meng Q, Zhang G.
    Toxicol Appl Pharmacol; 2012 Jan 01; 258(1):19-25. PubMed ID: 22085495
    [Abstract] [Full Text] [Related]

  • 9. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug 01; 14(8):965-74. PubMed ID: 11511170
    [Abstract] [Full Text] [Related]

  • 10. Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.
    Yamamoto Y, Yamazaki H, Ikeda T, Watanabe T, Iwabuchi H, Nakajima M, Yokoi T.
    Drug Metab Dispos; 2002 Feb 01; 30(2):155-60. PubMed ID: 11792684
    [Abstract] [Full Text] [Related]

  • 11. Effect of troglitazone on the liver of a Gunn rat model of genetic enzyme polymorphism.
    Watanabe T, Furukawa T, Sharyo S, Ohashi Y, Yasuda M, Takaoka M, Manabe S.
    J Toxicol Sci; 2000 Dec 01; 25(5):423-31. PubMed ID: 11201173
    [Abstract] [Full Text] [Related]

  • 12. Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat.
    Funk C, Ponelle C, Scheuermann G, Pantze M.
    Mol Pharmacol; 2001 Mar 01; 59(3):627-35. PubMed ID: 11179459
    [Abstract] [Full Text] [Related]

  • 13. Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.
    Herman JR, Dethloff LA, McGuire EJ, Parker RF, Walsh KM, Gough AW, Masuda H, de la Iglesia FA.
    Toxicol Sci; 2002 Jul 01; 68(1):226-36. PubMed ID: 12075125
    [Abstract] [Full Text] [Related]

  • 14. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

  • 15. Gene expression analysis of troglitazone reveals its impact on multiple pathways in cell culture: a case for in vitro platforms combined with gene expression analysis for early (idiosyncratic) toxicity screening.
    Vansant G, Pezzoli P, Saiz R, Birch A, Duffy C, Ferre F, Monforte J.
    Int J Toxicol; 2006 Nov 10; 25(2):85-94. PubMed ID: 16597547
    [Abstract] [Full Text] [Related]

  • 16. Phenol sulfotransferase, ST1A3, as the main enzyme catalyzing sulfation of troglitazone in human liver.
    Honma W, Shimada M, Sasano H, Ozawa S, Miyata M, Nagata K, Ikeda T, Yamazoe Y.
    Drug Metab Dispos; 2002 Aug 10; 30(8):944-9. PubMed ID: 12124314
    [Abstract] [Full Text] [Related]

  • 17. Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.
    Guo L, Zhang L, Sun Y, Muskhelishvili L, Blann E, Dial S, Shi L, Schroth G, Dragan YP.
    Mol Divers; 2006 Aug 10; 10(3):349-60. PubMed ID: 17031537
    [Abstract] [Full Text] [Related]

  • 18. Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes.
    Shishido S, Koga H, Harada M, Kumemura H, Hanada S, Taniguchi E, Kumashiro R, Ohira H, Sato Y, Namba M, Ueno T, Sata M.
    Hepatology; 2003 Jan 10; 37(1):136-47. PubMed ID: 12500198
    [Abstract] [Full Text] [Related]

  • 19. Chronic toxicity in monkeys with the thiazolidinedione antidiabetic agent troglitazone.
    Rothwell C, McGuire EJ, Altrogge DM, Masuda H, de la Iglesia FA.
    J Toxicol Sci; 2002 Feb 10; 27(1):35-47. PubMed ID: 11915367
    [Abstract] [Full Text] [Related]

  • 20. Troglitazone inhibits fatty acid oxidation and esterification, and gluconeogenesis in isolated hepatocytes from starved rats.
    Fulgencio JP, Kohl C, Girard J, Pégorier JP.
    Diabetes; 1996 Nov 10; 45(11):1556-62. PubMed ID: 8866561
    [Abstract] [Full Text] [Related]

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