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468 related items for PubMed ID: 11306531

  • 1. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic.
    Hondeghem LM, Carlsson L, Duker G.
    Circulation; 2001 Apr 17; 103(15):2004-13. PubMed ID: 11306531
    [Abstract] [Full Text] [Related]

  • 2. Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia.
    Hondeghem LM, Dujardin K, De Clerck F.
    Cardiovasc Res; 2001 May 17; 50(2):345-53. PubMed ID: 11334838
    [Abstract] [Full Text] [Related]

  • 3. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability).
    Hondeghem LM.
    Novartis Found Symp; 2005 May 17; 266():235-44; discussion 244-50. PubMed ID: 16050272
    [Abstract] [Full Text] [Related]

  • 4. Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs.
    Valentin JP, Hoffmann P, De Clerck F, Hammond TG, Hondeghem L.
    J Pharmacol Toxicol Methods; 2004 May 17; 49(3):171-81. PubMed ID: 15172013
    [Abstract] [Full Text] [Related]

  • 5. Disturbances of cardiac wavelength and repolarization precede Torsade de Pointes and ventricular fibrillation in Langendorff perfused rabbit hearts.
    Hondeghem LM.
    Prog Biophys Mol Biol; 2016 May 17; 121(1):3-10. PubMed ID: 26980523
    [Abstract] [Full Text] [Related]

  • 6. Nonclinical proarrhythmia models: predicting Torsades de Pointes.
    Lawrence CL, Pollard CE, Hammond TG, Valentin JP.
    J Pharmacol Toxicol Methods; 2005 May 17; 52(1):46-59. PubMed ID: 15975832
    [Abstract] [Full Text] [Related]

  • 7. Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.
    Guérard NC, Traebert M, Suter W, Dumotier BM.
    J Pharmacol Toxicol Methods; 2008 May 17; 58(1):32-40. PubMed ID: 18582585
    [Abstract] [Full Text] [Related]

  • 8. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 May 17; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 9. Oscillations of cardiac wave length and proarrhythmia.
    Hondeghem LM, Dumotier B, Traebert M.
    Naunyn Schmiedebergs Arch Pharmacol; 2010 Oct 17; 382(4):367-76. PubMed ID: 20803191
    [Abstract] [Full Text] [Related]

  • 10. Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies.
    Ducroq J, Printemps R, Guilbot S, Gardette J, Salvetat C, Le Grand M.
    J Pharmacol Toxicol Methods; 2007 Oct 17; 56(2):159-70. PubMed ID: 17604185
    [Abstract] [Full Text] [Related]

  • 11. Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.
    Shah RR, Hondeghem LM.
    Heart Rhythm; 2005 Jul 17; 2(7):758-72. PubMed ID: 15992736
    [Abstract] [Full Text] [Related]

  • 12. Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability.
    Hondeghem LM, Hoffmann P.
    J Cardiovasc Pharmacol; 2003 Jan 17; 41(1):14-24. PubMed ID: 12500017
    [Abstract] [Full Text] [Related]

  • 13. Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.
    Milberg P, Hilker E, Ramtin S, Cakir Y, Stypmann J, Engelen MA, Mönnig G, Osada N, Breithardt G, Haverkamp W, Eckardt L.
    J Cardiovasc Electrophysiol; 2007 Jun 17; 18(6):647-54. PubMed ID: 17388913
    [Abstract] [Full Text] [Related]

  • 14. Electrophysiologic characterization of the antipsychotic drug sertindole in a rabbit heart model of torsade de pointes: low torsadogenic potential despite QT prolongation.
    Eckardt L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Jan 17; 300(1):64-71. PubMed ID: 11752098
    [Abstract] [Full Text] [Related]

  • 15. Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts.
    Dujardin KS, Dumotier B, David M, Guizy M, Valenzuela C, Hondeghem LM.
    Am J Physiol Heart Circ Physiol; 2008 Oct 17; 295(4):H1414-21. PubMed ID: 18676685
    [Abstract] [Full Text] [Related]

  • 16. Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential.
    Amos GJ, Abrahamsson C, Duker G, Hondeghem L, Palmer M, Carlsson L.
    Cardiovasc Res; 2001 Feb 01; 49(2):351-60. PubMed ID: 11164845
    [Abstract] [Full Text] [Related]

  • 17. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.
    Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943
    [Abstract] [Full Text] [Related]

  • 18. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
    Milberg P, Eckardt L, Bruns HJ, Biertz J, Ramtin S, Reinsch N, Fleischer D, Kirchhof P, Fabritz L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Oct 28; 303(1):218-25. PubMed ID: 12235254
    [Abstract] [Full Text] [Related]

  • 19. A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes.
    Lawrence CL, Bridgland-Taylor MH, Pollard CE, Hammond TG, Valentin JP.
    Br J Pharmacol; 2006 Dec 28; 149(7):845-60. PubMed ID: 17031389
    [Abstract] [Full Text] [Related]

  • 20. Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia.
    Fabritz L, Kirchhof P, Franz MR, Eckardt L, Mönnig G, Milberg P, Breithardt G, Haverkamp W.
    Basic Res Cardiol; 2003 Feb 28; 98(1):25-32. PubMed ID: 12494266
    [Abstract] [Full Text] [Related]

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