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196 related items for PubMed ID: 11334570

  • 1. 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.
    Rowley M, Hallett DJ, Goodacre S, Moyes C, Crawforth J, Sparey TJ, Patel S, Marwood R, Patel S, Thomas S, Hitzel L, O'Connor D, Szeto N, Castro JL, Hutson PH, MacLeod AM.
    J Med Chem; 2001 May 10; 44(10):1603-14. PubMed ID: 11334570
    [Abstract] [Full Text] [Related]

  • 2. 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
    Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM.
    J Med Chem; 2002 Jan 17; 45(2):492-503. PubMed ID: 11784153
    [Abstract] [Full Text] [Related]

  • 3. 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.
    Crawforth J, Goodacre S, Maxey R, Bourrain S, Patel S, Marwood R, O'Connor D, Herbert R, Hutson P, Rowley M.
    Bioorg Med Chem Lett; 2000 Dec 18; 10(24):2701-3. PubMed ID: 11133072
    [Abstract] [Full Text] [Related]

  • 4. Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.
    Andersen K, Perregaard J, Arnt J, Nielsen JB, Begtrup M.
    J Med Chem; 1992 Dec 25; 35(26):4823-31. PubMed ID: 1336054
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor.
    Moloney GP, Martin GR, Mathews N, Milne A, Hobbs H, Dodsworth S, Sang PY, Knight C, Williams M, Maxwell M, Glen RC.
    J Med Chem; 1999 Jul 15; 42(14):2504-26. PubMed ID: 10411472
    [Abstract] [Full Text] [Related]

  • 6. 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
    Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM.
    J Med Chem; 1999 Feb 25; 42(4):691-705. PubMed ID: 10052976
    [Abstract] [Full Text] [Related]

  • 7. Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
    Peglion JL, Goument B, Despaux N, Charlot V, Giraud H, Nisole C, Newman-Tancredi A, Dekeyne A, Bertrand M, Genissel P, Millan MJ.
    J Med Chem; 2002 Jan 03; 45(1):165-76. PubMed ID: 11754589
    [Abstract] [Full Text] [Related]

  • 8. 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
    Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Böttcher H.
    J Med Chem; 2000 Mar 23; 43(6):1149-57. PubMed ID: 10737747
    [Abstract] [Full Text] [Related]

  • 9. New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
    Brea J, Rodrigo J, Carrieri A, Sanz F, Cadavid MI, Enguix MJ, Villazón M, Mengod G, Caro Y, Masaguer CF, Raviña E, Centeno NB, Carotti A, Loza MI.
    J Med Chem; 2002 Jan 03; 45(1):54-71. PubMed ID: 11754579
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
    Fedouloff M, Hossner F, Voyle M, Ranson J, Powles J, Riley G, Sanger G.
    Bioorg Med Chem; 2001 Aug 03; 9(8):2119-28. PubMed ID: 11504648
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor.
    Sternfeld F, Guiblin AR, Jelley RA, Matassa VG, Reeve AJ, Hunt PA, Beer MS, Heald A, Stanton JA, Sohal B, Watt AP, Street LJ.
    J Med Chem; 1999 Feb 25; 42(4):677-90. PubMed ID: 10052975
    [Abstract] [Full Text] [Related]

  • 12. Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.
    Perregaard J, Andersen K, Hyttel J, Sánchez C.
    J Med Chem; 1992 Dec 25; 35(26):4813-22. PubMed ID: 1336053
    [Abstract] [Full Text] [Related]

  • 13. Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
    van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL.
    J Med Chem; 1999 Jun 17; 42(12):2087-104. PubMed ID: 10377215
    [Abstract] [Full Text] [Related]

  • 14. S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.
    Millan MJ, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D, Newman-Tancredi A, Kamal M, Boutin JA, Jockers R, Marin P, Bockaert J, Muller O, Dekeyne A, Lavielle G.
    J Pharmacol Exp Ther; 2012 Mar 17; 340(3):750-64. PubMed ID: 22178752
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT₆ receptor antagonists.
    Nirogi R, Shinde A, Daulatabad A, Kambhampati R, Gudla P, Shaik M, Gampa M, Balasubramaniam S, Gangadasari P, Reballi V, Badange R, Bojja K, Subramanian R, Bhyrapuneni G, Muddana N, Jayarajan P.
    J Med Chem; 2012 Nov 08; 55(21):9255-69. PubMed ID: 23006002
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
    Asproni B, Pau A, Bitti M, Melosu M, Cerri R, Dazzi L, Seu E, Maciocco E, Sanna E, Busonero F, Talani G, Pusceddu L, Altomare C, Trapani G, Biggio G.
    J Med Chem; 2002 Oct 10; 45(21):4655-68. PubMed ID: 12361392
    [Abstract] [Full Text] [Related]

  • 17. 2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor.
    Kikuchi C, Ando T, Watanabe T, Nagaso H, Okuno M, Hiranuma T, Koyama M.
    J Med Chem; 2002 May 23; 45(11):2197-206. PubMed ID: 12014957
    [Abstract] [Full Text] [Related]

  • 18. Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.
    Perregaard J, Moltzen EK, Meier E, Sánchez C.
    J Med Chem; 1995 May 26; 38(11):1998-2008. PubMed ID: 7783131
    [Abstract] [Full Text] [Related]

  • 19. The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
    Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD.
    J Med Chem; 1998 Apr 09; 41(8):1218-35. PubMed ID: 9548813
    [Abstract] [Full Text] [Related]

  • 20. New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
    Liégeois JF, Eyrolles L, Ellenbroek BA, Lejeune C, Carato P, Bruhwyler J, Géczy J, Damas J, Delarge J.
    J Med Chem; 2002 Nov 07; 45(23):5136-49. PubMed ID: 12408724
    [Abstract] [Full Text] [Related]

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