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Journal Abstract Search

292 related items for PubMed ID: 11356141

  • 1. Predicting drug pharmacokinetics in humans from in vitro metabolism studies.
    McGinnity DF, Riley RJ.
    Biochem Soc Trans; 2001 May; 29(Pt 2):135-9. PubMed ID: 11356141
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  • 2. Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s.
    McGinnity DF, Parker AJ, Soars M, Riley RJ.
    Drug Metab Dispos; 2000 Nov; 28(11):1327-34. PubMed ID: 11038161
    [Abstract] [Full Text] [Related]

  • 3. Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli.
    McGinnity DF, Griffin SJ, Moody GC, Voice M, Hanlon S, Friedberg T, Riley RJ.
    Drug Metab Dispos; 1999 Sep; 27(9):1017-23. PubMed ID: 10460801
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  • 4. Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.
    Chen Y, Liu L, Nguyen K, Fretland AJ.
    Drug Metab Dispos; 2011 Mar; 39(3):373-82. PubMed ID: 21148079
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  • 5. Prediction of cytochrome P450-mediated drug clearance in humans based on the measured activities of selected CYPs.
    Gao J, Wang J, Gao N, Tian X, Zhou J, Fang Y, Zhang HF, Wen Q, Jia LJ, Zou D, Qiao HL.
    Biosci Rep; 2017 Dec 22; 37(6):. PubMed ID: 29054967
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  • 6. Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data.
    Li XQ, Björkman A, Andersson TB, Gustafsson LL, Masimirembwa CM.
    Eur J Clin Pharmacol; 2003 Sep 22; 59(5-6):429-42. PubMed ID: 12920490
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  • 7. Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine.
    Olesen OV, Linnet K.
    Br J Clin Pharmacol; 2000 Dec 22; 50(6):563-71. PubMed ID: 11136295
    [Abstract] [Full Text] [Related]

  • 8. Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
    Stringer RA, Strain-Damerell C, Nicklin P, Houston JB.
    Drug Metab Dispos; 2009 May 22; 37(5):1025-34. PubMed ID: 19196847
    [Abstract] [Full Text] [Related]

  • 9. Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.
    Venkatakrishnan K, Von Moltke LL, Greenblatt DJ.
    J Clin Pharmacol; 2001 Nov 22; 41(11):1149-79. PubMed ID: 11697750
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  • 10. Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.
    Emoto C, Murayama N, Rostami-Hodjegan A, Yamazaki H.
    Curr Drug Metab; 2010 Oct 22; 11(8):678-85. PubMed ID: 20973757
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  • 12. Approach to predict the contribution of cytochrome P450 enzymes to drug metabolism in the early drug-discovery stage: the effect of the expression of cytochrome b(5) with recombinant P450 enzymes.
    Emoto C, Iwasaki K.
    Xenobiotica; 2007 Sep 22; 37(9):986-99. PubMed ID: 17896325
    [Abstract] [Full Text] [Related]

  • 13. In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol.
    Usmani KA, Hodgson E, Rose RL.
    Chem Biol Interact; 2004 Dec 07; 150(3):221-32. PubMed ID: 15560889
    [Abstract] [Full Text] [Related]

  • 14. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
    Avent KM, DeVoss JJ, Gillam EM.
    Chem Res Toxicol; 2006 Jul 07; 19(7):914-20. PubMed ID: 16841959
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  • 16. Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.
    Venkatakrishnan K, von Moltke LL, Greenblatt DJ.
    J Pharmacol Exp Ther; 2001 Apr 07; 297(1):326-37. PubMed ID: 11259560
    [Abstract] [Full Text] [Related]

  • 17. Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
    Di L, Kerns EH, Li SQ, Carter GT.
    Int J Pharm; 2007 Apr 20; 335(1-2):1-11. PubMed ID: 17137735
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